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Amino Acid
L-Citrulline for Endothelial Function in Aging
Phase 1
Recruiting
Led By Andriy Yabluchanskiy, MD, PhD
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week
Awards & highlights
Summary
This trial is studying the effects of L-Citrulline on brain blood vessel function. L-Citrulline is a supplement that can help improve blood flow by increasing nitric oxide levels in the body. The study focuses on older and less active people who often have lower nitric oxide levels. L-Citrulline has been shown to increase nitric oxide production, which can improve blood flow and has been studied for its effects on exercise performance and cardiovascular health.
Who is the study for?
This trial is for adults aged 21-45 or 55-90 with good hearing and vision, who can read/write in English, and give informed consent. It's not for those with active brain diseases, recent strokes, major uncontrolled psychiatric conditions, substance abuse issues, or those on similar treatments recently.
What is being tested?
The study tests the effects of a capsule containing L-Citrulline (2500 mg) on brain blood vessel function in healthy individuals as well as those experiencing aging-related changes.
What are the potential side effects?
While the side effects are not detailed here, L-Citrulline is generally considered safe but could potentially cause digestive symptoms like heartburn or changes in stomach acid production.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 1 week
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in neuronal activity
Change in neurovascular coupling using functional near infrared spectroscopy (fNIRS)
Change in neurovascular coupling using the dynamic retinal vessel analysis
Secondary study objectives
Blood collection
Change in Attention
Change in Executive Function
+8 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: L-CitrullineExperimental Treatment1 Intervention
L-Citrulline 50 g/day per os for 1 week
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for aging, such as L-Citrulline, work by enhancing nitric oxide (NO) production, which is crucial for improving vascular function. NO is a key molecule that helps relax blood vessels, improve blood flow, and reduce oxidative stress.
This is particularly important for aging patients as it can mitigate endothelial dysfunction, a common issue that contributes to cognitive decline and cardiovascular diseases. By improving vascular health, these treatments help maintain cognitive function and reduce the risk of cardiovascular events, thereby enhancing the overall quality of life for older adults.
L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure.l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.
L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure.l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
University of OklahomaLead Sponsor
467 Previous Clinical Trials
91,283 Total Patients Enrolled
3 Trials studying Aging
394 Patients Enrolled for Aging
Andriy Yabluchanskiy, MD, PhDPrincipal InvestigatorUniversity of Oklahoma
4 Previous Clinical Trials
310 Total Patients Enrolled
2 Trials studying Aging
246 Patients Enrolled for Aging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I do not have active brain disorders like MS, uncontrolled seizures, or brain cancer.I haven't taken Citrulline enhancers like L-Arginine in the last 4 weeks.I am between 21-45 or 55-90 years old.I have not had a stroke, except for a TIA, in the last 60 days.I can see and hear well enough to take part in exams.I understand and can agree to the study's procedures and risks.
Research Study Groups:
This trial has the following groups:- Group 1: L-Citrulline
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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