← Back to Search

Amino Acid

L-Citrulline for Endothelial Function in Aging

Phase 1
Recruiting
Led By Andriy Yabluchanskiy, MD, PhD
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week
Awards & highlights

Study Summary

This trial will explore the impact of L-Citrulline on brain vascular function to understand its effect on health and disease.

Who is the study for?
This trial is for adults aged 21-45 or 55-90 with good hearing and vision, who can read/write in English, and give informed consent. It's not for those with active brain diseases, recent strokes, major uncontrolled psychiatric conditions, substance abuse issues, or those on similar treatments recently.Check my eligibility
What is being tested?
The study tests the effects of a capsule containing L-Citrulline (2500 mg) on brain blood vessel function in healthy individuals as well as those experiencing aging-related changes.See study design
What are the potential side effects?
While the side effects are not detailed here, L-Citrulline is generally considered safe but could potentially cause digestive symptoms like heartburn or changes in stomach acid production.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in neuronal activity
Change in neurovascular coupling using functional near infrared spectroscopy (fNIRS)
Change in neurovascular coupling using the dynamic retinal vessel analysis
Secondary outcome measures
Blood collection
Change in Attention
Change in Executive Function
+8 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: L-CitrullineExperimental Treatment1 Intervention
L-Citrulline 50 g/day per os for 1 week

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of OklahomaLead Sponsor
455 Previous Clinical Trials
95,893 Total Patients Enrolled
3 Trials studying Aging
394 Patients Enrolled for Aging
Andriy Yabluchanskiy, MD, PhDPrincipal InvestigatorUniversity of Oklahoma
3 Previous Clinical Trials
96 Total Patients Enrolled
1 Trials studying Aging
32 Patients Enrolled for Aging

Media Library

L-Citrulline (Amino Acid) Clinical Trial Eligibility Overview. Trial Name: NCT05722860 — Phase 1
Aging Research Study Groups: L-Citrulline
Aging Clinical Trial 2023: L-Citrulline Highlights & Side Effects. Trial Name: NCT05722860 — Phase 1
L-Citrulline (Amino Acid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05722860 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is eligibility for this trial contingent upon one's age exceeding 18 years?

"Per the requirements for participation, eligible individuals must be between 18 and 90 years old."

Answered by AI

Who is eligible to partake in this investigation?

"In order to meet the eligibility requirements for this study, patients must have l-citrulline levels and be between 18 and 90 years old. Approximately 30 participants are being recruited in total."

Answered by AI

Has the FDA sanctioned L-Citrulline for therapeutic application?

"Our team assessed L-Citrulline's safety to be a 1 due to the dearth of data regarding efficacy and safety, given this is an initial clinical trial."

Answered by AI

Are the doors open yet for enrollment in this trial?

"As evidenced on clinicaltrials.gov, this medical trial is no longer looking for participants as the last update was made February 1st 2023; nonetheless, there are 238 alternative studies that are presently recruiting patients."

Answered by AI

What are the goals of this experiment?

"The principal goal of this 1 week clinical trial is to evaluate the impact on neurovascular coupling through dynamic retinal vessel analysis. Secondary objectives cover macrovascular endothelial function (through sonography and flow-mediated dilation), glycocalyx - perfused boundary region (via the GlycoCheck camera) as well as capillary density measurements with the same device."

Answered by AI

Who else is applying?

What state do they live in?
Kansas
What site did they apply to?
Andriy Yabluchanskiy
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1
Recent research and studies
clinicaltrials.govStudy
L-Citrulline and Endothelial Function
2024. "L-Citrulline and Endothelial Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05722860.
~10 spots leftby Jul 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top