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Personalized Tobacco Treatment for Smoking Cessation

N/A
Recruiting
Led By Li-Shiun Chen, ScD, MD, MPH
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up exit interview [after last patient is enrolled per clinician at the time of the last intervention (approximately 3 years)]
Awards & highlights

Study Summary

This trial looks at how personalized treatment plans based on a patient's medical info and genetics can help them quit smoking and how it affects doctors prescribing it.

Who is the study for?
The MOTIVATE trial is for adult smokers who currently smoke at least 5 cigarettes per day and have used or been prescribed smoking cessation medication in the last month. It's also for clinicians from participating clinics who are adults and speak English.Check my eligibility
What is being tested?
This study tests a personalized tobacco treatment against usual care in primary care settings. The new approach uses clinical, genetic, and biomarker data to tailor recommendations, aiming to improve patient adherence and clinician prescribing practices.See study design
What are the potential side effects?
Since this trial focuses on comparing different approaches to smoking cessation rather than specific medications, side effects may vary based on the particular treatments recommended within each approach.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~exit interview [after last patient is enrolled per clinician at the time of the last intervention (approximately 3 years)]
This trial's timeline: 3 weeks for screening, Varies for treatment, and exit interview [after last patient is enrolled per clinician at the time of the last intervention (approximately 3 years)] for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Patient receipt of tobacco treatment medication for smoking cessation
Patient smoking abstinence
Patient use of cessation medication
Secondary outcome measures
Abstinence Outcomes Across Multiple Time Points
Patient medication adherence
Patient receipt of recommended tobacco treatment
+3 more
Other outcome measures
Outcome expectancies (Clinician)
Outcome expectancies (Patient)
Perceived benefits (Clinician)
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PrecisionTxExperimental Treatment1 Intervention
Physicians will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment. Patients will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist.
Group II: Usual CareActive Control1 Intervention
The arm will represent usual care in the primary care clinics. Physicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,937 Previous Clinical Trials
2,298,845 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,470 Previous Clinical Trials
2,618,881 Total Patients Enrolled
Li-Shiun Chen, ScD, MD, MPHPrincipal InvestigatorWashington University School of Medicine

Media Library

Precision Treatment Clinical Trial Eligibility Overview. Trial Name: NCT05846841 — N/A
Smoking Cessation Research Study Groups: Usual Care, PrecisionTx
Smoking Cessation Clinical Trial 2023: Precision Treatment Highlights & Side Effects. Trial Name: NCT05846841 — N/A
Precision Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT05846841 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still availability for enrolment in this research project?

"An examination of clinicaltrials.gov reveals that this medical trial, which was posted on June 1st 2023 is not actively enrolling new participants. The last update to the study occurred 4 months ago and thus far 200 other trials are currently looking for volunteers."

Answered by AI

What is the overarching goal of this experiment?

"This trial's primary objective, to be assessed six months following the intervention, is gauging patient compliance with cessation medication. Secondary outcomes encompass measure of adherence such as proportion of prescribed medications taken and smoking abstinence verified through biological testing across multiple time frames."

Answered by AI

Who else is applying?

What site did they apply to?
Washington University School of Medicine
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
2023. "Personalized Tobacco Treatment in Primary Care (MOTIVATE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05846841.
~567 spots leftby Mar 2028
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