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Light Therapy for Circadian Rhythm Disorders in Adolescents (ALT Trial)

N/A
Recruiting
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Between 18-20 years old
between 18-20 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in dlmo phase from baseline (day 8) to final phase assessment (day 13)
Awards & highlights

ALT Trial Summary

This trial is testing whether light exposure at different times of day can help shift the body's natural sleep cycle earlier, which may help improve academic performance, reduce conduct problems, and improve mood in adolescents.

Who is the study for?
This trial is for late adolescents aged 18-20 who live in or near Chicago, IL. It's designed to help those struggling with sleep issues and circadian rhythm misalignment that can lead to mood problems, poor academic performance, and health risks.Check my eligibility
What is being tested?
The study tests if afternoon bright light exposure can adjust the body's clock better than or in addition to morning light. Participants will be divided into four groups: afternoon light, morning light, both times of day, or dim control light over a two-week period.See study design
What are the potential side effects?
Potential side effects may include eye strain from bright lights (photophobia), changes in sleep patterns which could affect mood and alertness temporarily as the body adjusts to new rhythms.

ALT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 20 years old.
Select...
I am between 18 and 20 years old.

ALT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in dlmo phase from baseline (day 8) to final phase assessment (day 13)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in dlmo phase from baseline (day 8) to final phase assessment (day 13) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dim Light Melatonin Onset (DLMO) Phase Shift Change

ALT Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Morning Bright Light Only (MBL)Experimental Treatment2 Interventions
Participants in the morning bright light (MBL) group will receive a 3-h bright light exposure from 2 light boxes on 3 consecutive mornings in the laboratory. Bright light will be timed for each individual based on their baseline sleep schedule to shift the circadian timing system earlier ("phase advance").
Group II: Morning + Afternoon Light (MBL+ ABL)Experimental Treatment2 Interventions
Participants in the morning bright light + afternoon bright light (MBL+ ABL) group will receive bright light from 2 light boxes on 3 consecutive days in the laboratory. The morning exposure will be 1.5 h and the afternoon exposure will be 1.5 h. Bright light exposures will be timed for each individual based on their baseline sleep schedule to shift the circadian timing system earlier ("phase advance").
Group III: Afternoon Light Only (ABL)Experimental Treatment2 Interventions
Participants in the afternoon bright light (ABL) group will receive a 3-h bright light exposure from 2 light boxes on 3 consecutive afternoons in the laboratory. Bright light will be timed for each individual based on their baseline sleep schedule to shift the circadian timing system earlier ("phase advance").
Group IV: Dim Room Light ControlPlacebo Group2 Interventions
Participants in the dim room light control group will not receive any bright light exposure.

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,388 Total Patients Enrolled

Media Library

Baseline Sleep Satiation and Phase Stabilization Clinical Trial Eligibility Overview. Trial Name: NCT04753190 — N/A
Circadian Rhythm Research Study Groups: Morning + Afternoon Light (MBL+ ABL), Dim Room Light Control, Morning Bright Light Only (MBL), Afternoon Light Only (ABL)
Circadian Rhythm Clinical Trial 2023: Baseline Sleep Satiation and Phase Stabilization Highlights & Side Effects. Trial Name: NCT04753190 — N/A
Baseline Sleep Satiation and Phase Stabilization 2023 Treatment Timeline for Medical Study. Trial Name: NCT04753190 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still avails for participants in this research trial?

"Clinicaltrials.gov has verified that recruitment for this medical trial is currently in progress; the study was first made available on August 22nd 2022 and its details were revised as recently as October 26th of the same year."

Answered by AI

Are there any age restrictions for participants in this clinical inquiry?

"The eligibility for this experiment is limited to those between 18 and 20 years of age. For minors, there are 32 trials available, whereas individuals over 65 may enroll in 92 separate studies."

Answered by AI

Who meets the qualifications for this research endeavor?

"To qualify for the study, volunteers must be between 18 and 20 years old with light skin. The total participant count is expected to reach 113 individuals."

Answered by AI

What is the maximum capacity for this experiment's participant pool?

"Affirmative. Clinicaltrials.gov data attest to the ongoing recruitment for this clinical study, which was first made available on August 22nd 2022. The trial requires 113 participants from one medical centre and has been recently updated on October 26th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
How old are they?
65+
What site did they apply to?
Rush University Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Light Timing Study
2022. "Light Timing Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04753190.
~63 spots leftby Jun 2026
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