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What is Zosyn
TazobactamThe Generic name of this drug
Treatment SummaryAmdinocillin is an antibiotic derived from ampicillin that is used to treat infections caused by Pseudomonas bacteria. It is usually used in combination with other antibiotics.
Zosynis the brand name
Zosyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zosyn
Tazobactam
1993
153
Approved as Treatment by the FDA
Tazobactam, commonly known as Zosyn, is approved by the FDA for 1 uses including Abdominal Infection .Abdominal Infection
Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane
Effectiveness
How Zosyn Affects PatientsPiperacillin is a type of antibiotic that is used to treat bacterial infections caused by certain types of bacteria. It works by preventing the bacteria from forming their cell walls, which stops them from growing. It is able to resist being broken down by certain enzymes, so it can fight many different kinds of bacteria.
How Zosyn works in the bodyPiperacillin works by binding to certain proteins in the bacterial cell wall. This prevents the bacteria from completing the process of creating a new cell wall. This leaves the bacteria vulnerable to its own cell wall-destroying enzymes, which causes the bacteria to break apart and die.
When to interrupt dosage
The recommended amount of Zosyn is subject to the diagnosed circumstance, such as Contagious Diseases, Nosocomial Pneumonia and Communicable Diseases. The dosage varies based on the mode of administration (e.g. Powder, for solution - Intramuscular; Intravenous or Injection, powder, lyophilized, for solution) enumerated in the table below.Condition
Dosage
Administration
Abdominal Infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Healthcare-Associated Pneumonia
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Urinary tract infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Pneumonia, Bacterial
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Pyelonephritis
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Warnings
Zosyn ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Common Zosyn Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Minor
The excretion of Didanosine can be decreased when combined with Tazobactam.
Grepafloxacin
Minor
The excretion of Grepafloxacin can be decreased when combined with Tazobactam.
Lamivudine
Minor
The excretion of Lamivudine can be decreased when combined with Tazobactam.
Levofloxacin
Minor
The excretion of Levofloxacin can be decreased when combined with Tazobactam.
Stavudine
Minor
The excretion of Stavudine can be decreased when combined with Tazobactam.
Zosyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Zosyn?
Currently, 126 active clinical trials are being conducted to examine the potential of Zosyn to manage Animal bite, Pelvic Infections and Nosocomial Pneumonia.Condition
Clinical Trials
Trial Phases
Urinary tract infection
2 Actively Recruiting
Phase 2, Phase 3
Pneumonia, Bacterial
6 Actively Recruiting
Not Applicable, Phase 4
Pyelonephritis
4 Actively Recruiting
Not Applicable, Phase 3
Healthcare-Associated Pneumonia
0 Actively Recruiting
Abdominal Infection
0 Actively Recruiting
Zosyn Reviews: What are patients saying about Zosyn?
5Patient Review
10/12/2016 I've tried oral medication for three months now, to no avail. I'm currently in the hospital and we've switched tactics. I'm using 3.375gm per 100ml 4 times a day and it's working well so far with no negative side effects after 5 days.
5Patient Review
1/29/2017 After being in the hospital for four days, I felt much better. However, a few days after finishing the medication, I began to experience night sweats.
5Patient Review
10/14/2021 After just two days of this medication, I noticed a significant decrease in pain related to my diverticulitis. I had no issues whatsoever with the medication and was able to leave the hospital pain-free.
5Patient Review
8/12/2013 I ruptured my appendix, but arrived at the ER just in time. They put me on Zosyn every 6 hours for a total of 13 round the clock administrations. It was touch-and-go there for a while, but I'm grateful to be alive and kicking today.
4.7Patient Review
1/28/2013 I was given this medication after hernia surgery. I had some fluid around the mesh. Within 36 hours I had a rash all over my body which I was then diagnosed with Steven's Jojnson Syndrome (skin fell off entire body). Along with that my kidneys shut down. Just before they were to put me on dialisys my kidneys began to improve. 6 weeks later I am still in the hospital waiting for skins issues to heal. Be careful with all medications please!
4.3Patient Review
10/24/2018 I had a liver abscess due to gallbladder removal surgery and I'm still on this medicine. The taste is bitter and I get pimples, hives, and itchiness all over my body. But overall, this is a good medicine for my disease.
4.3Patient Review
2/15/2015 I received this medication intravenously for a possible peritoneal infection following colon surgery for cancer. The peritoneal infection cleared, but I now have no taste and have lost my appetite completely. I also developed diarrhea and a superficial yeast infection.
4Patient Review
10/17/2018 I had a really severe foot infection that was starting to spread to the bone. I was on this medication intravenously for about ten weeks, but it didn't do much during the infection. surgery ended up being the best solution. Afterward, though, this medication seemed to work well. The only side effect I experienced was complete loss of taste, which made meals really unenjoyable for several weeks. Thankfully, my sense of taste came back after I finished taking the medication!
3Patient Review
5/28/2014 I developed a very bad case of pancreatitis as a result of a severe gallstone attack, and they immediately started me on Zosyn in the ER. They kept me on the antibiotic for a couple of days and the pancreatitis cleared up nicely, allowing them to do the gallbladder removal surgery. The medicine had no side effects for me -- I didn't even know it was going into my IV. It worked for me with no complications, so I was pleased with it.
2.7Patient Review
11/21/2018 I was hospitalized for pneumonia the first time I used this medication. It wasn't until the second time that I realized the drug had caused the hallucinations I'd experienced the first time.
1.3Patient Review
10/19/2013 I was admitted to the hospital due to an unknown skin infection. I stayed for four days, but had to return within eight hours due to swelling. I spent a total of three more days in the hospital before being released with oral medication. So far, the only side effect I've experienced is thrush.
Patient Q&A Section about zosyn
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of antibiotic is ZOSYN?
"Zosyn contains a combination of piperacillin and tazobactam, which are both penicillin antibiotics that fight bacteria in the body."
Answered by AI
What is the drug ZOSYN used to treat?
"Piperacillin/tazobactam is an antibiotic that is used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria."
Answered by AI
What bacteria does ZOSYN cover?
"Zosyn (piperacillin/tazobactam) is an antibiotic that is effective against many types of bacteria, including Gram-positive, Gram-negative, and anaerobic bacteria. It covers Streptococci, Staphylococci (but not methicillin-resistant S. aureus [MRSA]), Hemophilus, Moraxella, Enterobacteriaceae, and Pseudomonas aeruginosa."
Answered by AI