Zosyn

Pyelonephritis, Abdominal Infection, Healthcare-Associated Pneumonia + 2 more
Treatment
2 FDA approvals
5 Active Studies for Zosyn

What is Zosyn

TazobactamThe Generic name of this drug
Treatment SummaryAmdinocillin is an antibiotic derived from ampicillin that is used to treat infections caused by Pseudomonas bacteria. It is usually used in combination with other antibiotics.
Zosynis the brand name
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Zosyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zosyn
Tazobactam
1993
153

Approved as Treatment by the FDA

Tazobactam, commonly known as Zosyn, is approved by the FDA for 2 uses including complicated intra-abdominal bacterial infections and Abdominal Infection .
complicated intra-abdominal bacterial infections
Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane
Abdominal Infection
Used to treat complicated intra-abdominal bacterial infections in combination with Ceftolozane

Effectiveness

How Zosyn Affects PatientsPiperacillin is a type of antibiotic that is used to treat bacterial infections caused by certain types of bacteria. It works by preventing the bacteria from forming their cell walls, which stops them from growing. It is able to resist being broken down by certain enzymes, so it can fight many different kinds of bacteria.
How Zosyn works in the bodyPiperacillin works by binding to certain proteins in the bacterial cell wall. This prevents the bacteria from completing the process of creating a new cell wall. This leaves the bacteria vulnerable to its own cell wall-destroying enzymes, which causes the bacteria to break apart and die.

When to interrupt dosage

The recommended amount of Zosyn is subject to the diagnosed circumstance, such as Contagious Diseases, Nosocomial Pneumonia and Communicable Diseases. The dosage varies based on the mode of administration (e.g. Powder, for solution - Intramuscular; Intravenous or Injection, powder, lyophilized, for solution) enumerated in the table below.
Condition
Dosage
Administration
Pyelonephritis
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Abdominal Infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Healthcare-Associated Pneumonia
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Urinary tract infection
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral
Pneumonia, Bacterial
, 25.0 mg/mL, 37.5 mg/mL, 5.0 mg/mL, 45.0 mg/mL, 50.0 mg/mL, 375.0 mg, 500.0 mg, 250.0 mg, 1500.0 mg, 4500.0 mg, 150.0 mg/mL, 15.0 mg/mL, 3.75 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intravenous, Intravenous; Parenteral, Injection, powder, lyophilized, for solution - Intravenous; Parenteral

Warnings

Zosyn Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Tazobactam may interact with Pulse Frequency
There are 20 known major drug interactions with Zosyn.
Common Zosyn Drug Interactions
Drug Name
Risk Level
Description
Didanosine
Minor
The excretion of Didanosine can be decreased when combined with Tazobactam.
Grepafloxacin
Minor
The excretion of Grepafloxacin can be decreased when combined with Tazobactam.
Lamivudine
Minor
The excretion of Lamivudine can be decreased when combined with Tazobactam.
Levofloxacin
Minor
The excretion of Levofloxacin can be decreased when combined with Tazobactam.
Stavudine
Minor
The excretion of Stavudine can be decreased when combined with Tazobactam.
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Zosyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Zosyn?

Currently, 126 active clinical trials are being conducted to examine the potential of Zosyn to manage Animal bite, Pelvic Infections and Nosocomial Pneumonia.
Condition
Clinical Trials
Trial Phases
Urinary tract infection
0 Actively Recruiting
Abdominal Infection
0 Actively Recruiting
Healthcare-Associated Pneumonia
1 Actively Recruiting
Not Applicable
Pyelonephritis
1 Actively Recruiting
Not Applicable
Pneumonia, Bacterial
3 Actively Recruiting
Not Applicable

Zosyn Reviews: What are patients saying about Zosyn?

5Patient Review
10/12/2016
Zosyn for Diabetic Foot Infection
I've tried oral medication for three months now, to no avail. I'm currently in the hospital and we've switched tactics. I'm using 3.375gm per 100ml 4 times a day and it's working well so far with no negative side effects after 5 days.
5Patient Review
1/29/2017
Zosyn for Diverticulitis
After being in the hospital for four days, I felt much better. However, a few days after finishing the medication, I began to experience night sweats.
5Patient Review
10/14/2021
Zosyn for Diverticulitis
After just two days of this medication, I noticed a significant decrease in pain related to my diverticulitis. I had no issues whatsoever with the medication and was able to leave the hospital pain-free.
5Patient Review
8/12/2013
Zosyn for Complicated Skin Infection
I ruptured my appendix, but arrived at the ER just in time. They put me on Zosyn every 6 hours for a total of 13 round the clock administrations. It was touch-and-go there for a while, but I'm grateful to be alive and kicking today.
4.7Patient Review
1/28/2013
Zosyn for Pneumonia caused by Bacteria
I was given this medication after hernia surgery. I had some fluid around the mesh. Within 36 hours I had a rash all over my body which I was then diagnosed with Steven's Jojnson Syndrome (skin fell off entire body). Along with that my kidneys shut down. Just before they were to put me on dialisys my kidneys began to improve. 6 weeks later I am still in the hospital waiting for skins issues to heal. Be careful with all medications please!
View All Reviews
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Patient Q&A Section about zosyn

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of antibiotic is ZOSYN?

"Zosyn contains a combination of piperacillin and tazobactam, which are both penicillin antibiotics that fight bacteria in the body."

Answered by AI

What is the drug ZOSYN used to treat?

"Piperacillin/tazobactam is an antibiotic that is used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria."

Answered by AI

What bacteria does ZOSYN cover?

"Zosyn (piperacillin/tazobactam) is an antibiotic that is effective against many types of bacteria, including Gram-positive, Gram-negative, and anaerobic bacteria. It covers Streptococci, Staphylococci (but not methicillin-resistant S. aureus [MRSA]), Hemophilus, Moraxella, Enterobacteriaceae, and Pseudomonas aeruginosa."

Answered by AI

Clinical Trials for Zosyn

Have you considered Zosyn clinical trials? We made a collection of clinical trials featuring Zosyn, we think they might fit your search criteria.
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