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What is Zorvolex
DiclofenacThe Generic name of this drug
Treatment SummaryDiclofenac is a type of non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by blocking enzymes that cause the production of substances in the body that cause inflammation and pain. Diclofenac is the product of a rational drug design and is often prescribed as a first-line therapy for various types of pain and inflammation. It is often used in combination with a medication called misoprostol to prevent stomach ulcers caused by NSAIDs. Diclofenac was first approved by the FDA in 1988 under the brand name Voltaren.
Voltarenis the brand name
Zorvolex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Voltaren
Diclofenac
1988
767
Approved as Treatment by the FDA
Diclofenac, also called Voltaren, is approved by the FDA for 10 uses including Osteoarthritis (OA) and Stomach Ulcer .Osteoarthritis (OA)
Used to treat Osteoarthritis (OA) in combination with Misoprostol
Stomach Ulcer
Used to treat develop NSAID-induced gastric ulcers in combination with Misoprostol
Osteoarthritis of the Knee
Used to treat Osteoarthritis of the Knee in combination with Capsaicin
Pain
Helps manage Pain
Osteoarthritis of the Knee
Used to treat Osteoarthritis of the Knee in combination with Capsaicin
Osteoarthritis
Used to treat Osteoarthritis (OA) in combination with Misoprostol
Rheumatoid Arthritis
Cataract Surgery
Postoperative Inflammatory Response
Chronic Pain
Helps manage Pain
Effectiveness
How Zorvolex Affects PatientsDiclofenac is an anti-inflammatory drug used to reduce pain and fever. Unfortunately, it can also reduce the amount of mucus in the stomach that helps protect it from ulcers.
How Zorvolex works in the bodyDiclofenac works by blocking enzymes responsible for creating molecules that cause pain and inflammation. It also affects how neurons respond to pain signals, making them less sensitive. Diclofenac also reduces swelling by stopping white blood cells from flowing to sites of inflammation. It blocks molecules that cause vasodilation and increase nutrient flow, too. In addition, it can reduce the body's overall immune response and stop certain molecules from crossing the blood-brain barrier, thus reducing fever.
When to interrupt dosage
The proposed dosage of Zorvolex is contingent upon the diagnosed condition, including Joint Pain, Postoperative Inflammatory Response and Osteoarthritis (OA). The quantity of dosage alters, per the administration modality (e.g. Cream; Kit; Solution or Kit; Oil; Solution / drops) identified in the table below.Condition
Dosage
Administration
Contusions
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Photophobia
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Muscle Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Inflammation
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Catarrh
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Chronic Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Pericarditis
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Fever
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Postoperative
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Acute Coryza
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
corneal refractive surgery
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Cataract Surgery
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Postoperative Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Arthritis, Gouty
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Pain
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Rheumatoid Arthritis
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Rheumatism
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Surgery, Dental
100.0 mg, , 1.0 mg/mL, 50.0 mg, 75.0 mg, 16.05 mg/mL, 3.5 mg/mL, 25.0 mg, 0.01 mg/mg, 180.0 mg, 0.018 mg/mg, 1.0 mg/mg, 0.1 %, 1.5 %, 30.0 mg/mL, 0.03 mg/mg, 2.32 %, 1.16 %, 37.5 mg/mL, 0.02 mg/mg, 18.0 mg, 35.0 mg, 0.3 mg/mg, 10.0 mg, 1000.0 mg, 10.0 mg/mL, 12.5 mg, 0.015 mg/mg, 100.0 mg/mL, 3.0 mg/mg, 5.7 mg/mg, 13.0 mg, 0.013 mg, 0.001 mg/mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ophthalmic, Solution, Solution - Ophthalmic, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Solution - Topical, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Oral, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Topical, Gel, Gel - Topical, Tablet, extended release, Tablet, extended release - Oral, Patch, Patch - Topical, Capsule, liquid filled, Capsule, liquid filled - Oral, Rectal, Suppository, Suppository - Rectal, Liquid - Ophthalmic, Kit, Aerosol, metered - Topical, Aerosol, metered, Kit - Topical, Tablet, sugar coated, Tablet, sugar coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Capsule, Capsule - Oral, Cream, Cream - Topical, Powder - Oral, Transdermal, Solution / drops - Transdermal, Oral; Topical, Kit - Oral; Topical, Sublingual, Tablet, coated, Tablet, coated - Oral, Drug delivery system, Drug delivery system - Topical
Warnings
Zorvolex ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Heart failure
Do Not Combine
Crohn's Disease
Do Not Combine
recent history of anal bleeding
Do Not Combine
Hemorrhagic Disorders
Do Not Combine
Gastritis
Do Not Combine
inflammatory lesions of the Rectum
Do Not Combine
active Gastrointestinal Bleeding
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
active Gastrointestinal Perforation
Do Not Combine
Duodenal Ulcer
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Ulcerative Colitis
Do Not Combine
Liver Diseases
Do Not Combine
Stroke
Do Not Combine
Third trimester of pregnancy
Do Not Combine
Hematochezia
Do Not Combine
Kidney Failure
Do Not Combine
Kidney Failure
Do Not Combine
Anus
Do Not Combine
Ulcer
Do Not Combine
damaged skin
Do Not Combine
Gastric ulcer
Do Not Combine
Peptic Ulcer
Do Not Combine
Hyperkalemia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Diclofenac may interact with Pulse Frequency
Common Zorvolex Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Diclofenac.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Diclofenac.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Diclofenac.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Diclofenac.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Diclofenac.
Zorvolex Toxicity & Overdose RiskSymptoms of Voltaren overdose may include tiredness, drowsiness, nausea, vomiting, stomach pain, and bleeding from the digestive tract. High blood pressure, kidney failure, shallow breathing, or coma can occur in rare cases. If the overdose happened within the last 4 hours, medical professionals may induce vomiting and administer activated charcoal.
Zorvolex Novel Uses: Which Conditions Have a Clinical Trial Featuring Zorvolex?
491 active clinical trials are currently underway to assess the potential of Zorvolex in ameliorating Inflammation, Argon Laser Trabeculoplasty and Osteoarthritis of the Knee.Condition
Clinical Trials
Trial Phases
Osteoarthritis of the Knee
95 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Chronic Pain
141 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Inflammation
64 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Dysmenorrhea
0 Actively Recruiting
Muscle Pain
1 Actively Recruiting
Phase 4
Conjunctivitis
0 Actively Recruiting
Musculoskeletal System
1 Actively Recruiting
Not Applicable
corneal refractive surgery
0 Actively Recruiting
Postoperative Inflammatory Response
1 Actively Recruiting
Phase 4
Photophobia
4 Actively Recruiting
Not Applicable
Postoperative Pain
18 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 3
Pain
3 Actively Recruiting
Not Applicable
Stomach Ulcer
0 Actively Recruiting
Rheumatism
0 Actively Recruiting
Juvenile arthritis
11 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3
radial keratotomy
0 Actively Recruiting
Joints
0 Actively Recruiting
Pericarditis
0 Actively Recruiting
Acute Coryza
0 Actively Recruiting
Zorvolex Reviews: What are patients saying about Zorvolex?
5Patient Review
3/30/2016 Even with my insurance and the savings card, Zorvolex is going to cost $193.00 for a 30 day supply--which is way too much. 800 mg of Iburophen works just as well for me and it's a lot cheaper.
5Patient Review
9/9/2015 Before taking this medication, I could hardly get out of bed. Walking was a real challenge. But this drug has helped me immensely and I am now able to live a relatively normal life again.
5Patient Review
10/14/2016 Though it does require a bit of budgeting for the copay, this treatment has been well worth it for me. It's helped with mysciatic pain, spinal stenosis, and osteoarthritis in my hands. I can definitely tell when I miss a dose.
5Patient Review
6/15/2016 I unfortunately got microscopic colitis after taking this medication. The diarrhea that resulted was truly awful. I had to take a steroid to get it under control, and my doctor says I'll have it for the rest of my life.
5Patient Review
8/11/2017 I found an old bottle of Zorvolex in my drawer, and even though it had expired by a full year, I decided to give it a try because the online reviews said it would help with inflammation. I'm so glad I took that chance! The pill worked amazingly, reducing the swelling and pain almost immediately. It was such a relief that I went back to my doctor and asked for more.
Patient Q&A Section about zorvolex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was Zorvolex discontinued?
"ZORVOLEX is not recommended for use in patients undergoing CABG surgery due to the increased risk of serious gastrointestinal adverse events associated with NSAIDs. These events can include bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal."
Answered by AI
How much Zorvolex should I take?
"For mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily. For osteoarthritis pain, the dosage is 35 mg orally three times daily."
Answered by AI
What is the difference between Zorvolex and diclofenac?
"ZORVOLEX is available in lower dosage strengths (18-mg and 35-mg capsules) compared with other formulations of diclofenac which contain the sodium or potassium salt of diclofenac (Figure 2)."
Answered by AI
What is the drug Zorvolex used for?
"It is used to relieve pain from various conditions such as muscle aches, backaches, dental pain, menstrual cramps, and sports injuries. By reducing symptoms such as pain, swelling, and stiffness, it allows patients to return to their normal daily activities."
Answered by AI
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