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What is Zoladex
GoserelinThe Generic name of this drug
Treatment SummaryGoserelin is a synthetic hormone used to reduce the levels of testosterone in men and estradiol in women. Both of these hormones can stimulate the growth of cancer cells, so reducing their levels can help to slow the growth of cancer. When the medication is stopped, hormone levels return to normal.
Zoladexis the brand name
Zoladex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zoladex
Goserelin
2003
6
Approved as Treatment by the FDA
Goserelin, also known as Zoladex, is approved by the FDA for 5 uses like stage T4 carcinoma of the prostate and stage T2b carcinoma of the prostate .stage T4 carcinoma of the prostate
Used to treat stage T4 carcinoma of the prostate in combination with Flutamide
stage T2b carcinoma of the prostate
Used to treat stage T2b carcinoma of the prostate in combination with Flutamide
Radiation Therapy
Used to treat Radiation Therapy in combination with Flutamide
Prostatic Neoplasms
Used to treat stage T2b carcinoma of the prostate in combination with Flutamide
Carcinoma
Used to treat stage T4 carcinoma of the prostate in combination with Flutamide
Effectiveness
How Zoladex Affects PatientsScientists have studied how Goserelin is absorbed and used in the body in both healthy adults and people with illnesses. It has been administered as either a 250 microgram liquid dose, or as a 3.6 milligram injection under the skin.
How Zoladex works in the bodyGoserelin is a synthetic version of a hormone that helps to suppress the production of other hormones in the pituitary gland. When used, it can reduce the levels of luteinizing hormone (LH) and testosterone in the body.
When to interrupt dosage
The measure of Zoladex is contingent upon the indicated illness, for example Uterine hemorrhage, Radiation Therapy and Advance Directives. The amount of dosage is dependent upon the mode of delivery as detailed in the table below.Condition
Dosage
Administration
Endometrial atrophy
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Advance Directives
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Prostatic Neoplasms
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Palliative Treatment
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Carcinoma
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Endometriosis
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Breast
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Radiation Therapy
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Uterine hemorrhage
, 3.6 mg, 10.8 mg
Subcutaneous, , Implant, Implant - Subcutaneous
Warnings
There are 20 known major drug interactions with Zoladex.Common Zoladex Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Goserelin is combined with Asenapine.
Zoladex Toxicity & Overdose RiskNo reports of overdose have been documented in clinical trials.
Zoladex Novel Uses: Which Conditions Have a Clinical Trial Featuring Zoladex?
53 active studies are currently assessing the potential of Zoladex to reduce Uterine hemorrhage, thin the Endometrium and alleviate Endometriosis.Condition
Clinical Trials
Trial Phases
Advance Directives
0 Actively Recruiting
Endometrial atrophy
0 Actively Recruiting
Carcinoma
0 Actively Recruiting
Palliative Treatment
1 Actively Recruiting
Phase 3
Endometriosis
30 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Breast
0 Actively Recruiting
Uterine hemorrhage
0 Actively Recruiting
Prostatic Neoplasms
0 Actively Recruiting
Radiation Therapy
6 Actively Recruiting
Not Applicable, Phase 3, Early Phase 1
Zoladex Reviews: What are patients saying about Zoladex?
5Patient Review
11/23/2015 I've been on Zolidex three times now, and it's really helped me control my endometriosis. I've had no major issues while taking it, just the occasional bout of stiff joints or hot flashes.
5Patient Review
11/7/2013 I am a Vietnam Veteran. My PSA was 58.5 and the cancer had spread outside the prostate. After 45 days of radiation, I was put on Zoladex to control the cancer. This drug has likely saved my life. I have hot flashes but that's a small price to pay for knowing my cancer is being treated effectively.
5Patient Review
7/5/2013 I've only been taking this medication for a short period of time, but it has already helped me in so many ways. At first I experienced some side effects like nausea and headaches; however, these have since subsided.
5Patient Review
5/15/2022 I had a prostatectomy and my PSA started rising, so my urologist put me on Zoladex as a precautionary measure. I agreed to the additional Zoladex and radiation therapy, and I'm glad I did. I feel great and my PSA is down.
5Patient Review
5/2/2022 Zoladex completely changed my life for the better. I was bleeding for two years straight and in a lot of pain most of the time. Zoladex has helped with that, although I do experience hot flushes, bad headaches, forgetfulness, low libido, whole body aches, little sleep, and mood swings. But I would rather deal with those symptoms than constant bleeding and pain.
Patient Q&A Section about zoladex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Zoladex used for?
"Goserelin treats breast cancer by lowering the amount of estrogen in the body. Estrogen is a hormone that can make some types of breast cancer grow. Goserelin is also used to treat prostate cancer."
Answered by AI
Why is Zoladex given in breast cancer?
"Zoladex is used to treat early-stage hormone-receptor-positive breast cancer in premenopausal women. It is given as an injection once a month for several months or every few months."
Answered by AI
Is Zoladex a chemotherapy?
"com
Zoladex is the brand name for the chemo drug goserelin. It is a man-made form of a hormone that is similar to the hormone GnRH (gonadotropin-releasing hormone). This drug is used in the treatment of several types of cancer, including breast cancer, endometrial cancer, and prostate cancer. It is also used to treat women with precocious puberty.
Zoladex is a chemo drug used to treat several types of cancer, including breast cancer, endometrial cancer, and prostate cancer. It is also used to treat women with precocious puberty."
Answered by AI
What are the Zoladex side effects?
"The following side effects may occur with the use of this medication: hot flashes (flushing), dizziness, headache, increased sweating, decreased sexual interest/ability, trouble sleeping, nausea, change in breast size, vaginal dryness, or hair loss. In addition, pain, bruising, bleeding, redness, or swelling at the injection site may also occur."
Answered by AI
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