Zestoretic

Nephrotic Syndrome, Ascites, Edema + 23 more
Treatment
22 FDA approvals
20 Active Studies for Zestoretic

What is Zestoretic

HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a diuretic drug that is commonly used to treat edema (swelling) and high blood pressure. It is the most widely prescribed thiazide diuretic, but it is being used less often in favor of other medications such as angiotensin converting enzyme inhibitors. Hydrochlorothiazide is also available in combination with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. It was approved by the FDA in 1959 and has been used since then to treat various conditions.
Esidrixis the brand name
image of different drug pills on a surface
Zestoretic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181

Approved as Treatment by the FDA

Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and hypokalemia with solo treatment .
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Edema
Helps manage Premenstrual tension with edema
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan

Effectiveness

How Zestoretic Affects PatientsHydrochlorothiazide helps the body get rid of extra water and salt through the urine. Doses of this drug can range between 25-100mg, depending on the individual. People with reduced kidney or liver function should be careful when taking hydrochlorothiazide.
How Zestoretic works in the bodyHydrochlorothiazide works by reducing the amount of sodium and water that is reabsorbed into the body. It does this by interfering with a transporter molecule in the distal convoluted tubule, called the sodium-chloride symporter. This stops the reabsorption of sodium, which creates a lower concentration gradient between the epithelial cell and the distal convoluted tubule, which in turn reduces the reabsorption of water.

When to interrupt dosage

The suggested measure of Zestoretic is based on the determined condition, like Antepartum magnesium sulfate prophylaxis, blood pressure inadequately moderated by monotherapy and antihypertensives. The quantity of dosage is contingent upon the delivery approach (e.g. Tablet, coated - Oral or Oral) specified in the table below.
Condition
Dosage
Administration
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Sodium retention
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
hypokalemia with solo treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Zestoretic has two contraindications, so it should not be taken if you have any of the conditions presented in the following table.Zestoretic Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
There are 20 known major drug interactions with Zestoretic.
Common Zestoretic Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Zestoretic Toxicity & Overdose RiskThe toxic dose of hydrochlorothiazide in mice and rats has been found to be more than 10g/kg. Those who overdose may experience low levels of potassium, chlorine, and sodium in their blood. Treatment may include giving fluids, electrolytes, and medications to raise blood pressure and improve breathing.
image of a doctor in a lab doing drug, clinical research

Zestoretic Novel Uses: Which Conditions Have a Clinical Trial Featuring Zestoretic?

158 active trials are being conducted to investigate the potential of Zestoretic to alleviate Cirrhosis, Edema and Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Diabetes Insipidus
1 Actively Recruiting
Phase 1
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
hypokalemia with solo treatment
0 Actively Recruiting
Antihypertensive Treatment
0 Actively Recruiting
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Swollen feet or ankles
42 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cirrhosis
49 Actively Recruiting
Phase 1, Not Applicable, Phase 4, Phase 3, Phase 2, Early Phase 1
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Diuretics
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Nephrolithiasis
0 Actively Recruiting
Renal tubular acidosis
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3

Zestoretic Reviews: What are patients saying about Zestoretic?

5Patient Review
10/12/2017
Zestoretic for High Blood Pressure
This medication is very effective at managing my blood pressure.
5Patient Review
12/31/2012
Zestoretic for Chronic Heart Failure
The only problem I notice being on this medicine is legs cramping up when I try to jog. I have never had problems with leg cramps and pulled muscles. My doctor instructed me to eat more bananas. I hope this works.
5Patient Review
12/18/2012
Zestoretic for High Blood Pressure
I was experiencing a terrible low back ache, drowsiness, and cough. I couldn't seem to clear my throat no matter what I did.
4.7Patient Review
11/21/2010
Zestoretic for High Blood Pressure
4.3Patient Review
10/12/2013
Zestoretic for High Blood Pressure
I was unfortunately unable to stay on this medication due to the constant coughing it produced.
4.3Patient Review
6/13/2011
Zestoretic for High Blood Pressure
Since taking this medicine, I have developed an insatiable craving for dill pickles (which I previously couldn't stand) and salt and vinegar chips. I also find myself wanting cheese and tomato juice more often than before. However, I have lost my taste for sweets altogether.
4Patient Review
4/29/2011
Zestoretic for High Blood Pressure
This treatment helps me with my bladder control.
4Patient Review
6/11/2011
Zestoretic for High Blood Pressure
I've been on this medication for eight years now, and it's been working great until recently. I've developed a terrible cough and leg discomfort. I had two stents put in my leg to clear a blockage, but I'm still having issues. I'm seeing the doctor in a couple of weeks to discuss it further.
3.7Patient Review
1/26/2013
Zestoretic for High Blood Pressure
This treatment has lowered my blood pressure, which is great.
3.7Patient Review
11/14/2011
Zestoretic for High Blood Pressure
I experienced indigestion, lightheadedness, and fatigue while taking this medication. Additionally, I would occasionally vomit or cough.
3.3Patient Review
11/26/2014
Zestoretic for High Blood Pressure
Dry cough is a common side effect of every ACE inhibitor, and can be suppressed by ferrous sulfate. However, I wonder how this medication can be used safely on a regular basis? Lisinopril blocks angiotensin convert into the active hormone, which appears to have certain anti-inflammatory properties that are beneficial for the cardiovascular system. However, hydrochlorothiazide depletes blood potassium levels, which can be harmful to the body.
3Patient Review
6/27/2018
Zestoretic for High Blood Pressure
I was really sick when I started this drug, and it's only gotten worse. I'm now experiencing a whole host of problems, including nausea, dizziness, and fainting spells. Neurapathy is also a serious concern. If you're considering this treatment, I would recommend switching to Propanalol instead.
3Patient Review
3/19/2014
Zestoretic for High Blood Pressure
Even after taking this medication for an extensive amount of time, my blood pressure is still only 150 over 80.
3Patient Review
12/16/2013
Zestoretic for High Blood Pressure
I've been on this medication for two weeks and have developed a really dry cough that causes me to urinate whenever I hack. Additionally, I'm feeling dizzy and lightheaded; though my blood pressure is normal at 118/70.
3Patient Review
12/30/2010
Zestoretic for High Blood Pressure
I experienced spells of coughing and fatigue, as well as pain in my shoulders and lower back when sitting.
3Patient Review
2/20/2013
Zestoretic for High Blood Pressure
I've been taking this treatment for eight years now and I haven't had any problems.
2.7Patient Review
7/16/2014
Zestoretic for High Blood Pressure
This cough medicine didn't really help with my dry cough.
2.3Patient Review
9/28/2010
Zestoretic for High Blood Pressure
1Patient Review
8/16/2014
Zestoretic for High Blood Pressure
I'm not sure if I should continue taking this medication because it lowers my blood pressure to an unsafe level.

Patient Q&A Section about zestoretic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Zestoretic used for?

"Zestoretic is a medication used to treat high blood pressure by combining the drugs lisinopril and hydrochlorothiazide."

Answered by AI

Is Zestoretic the same as lisinopril?

"Zestoretic is a combination medication that contains an ACE inhibitor and a diuretic. It is used to treat high blood pressure. Zestoretic is available as a generic drug."

Answered by AI

What drug class is Zestoretic?

"Zestoretic is a combination drug that contains lisinopril and hydrochlorothiazide. Lisinopril works by blocking ACE enzyme, which helps blood vessels to relax and lowers blood pressure. Hydrochlorothiazide belongs to a group of drugs called thiazide diuretics, which work by stopping reabsorption of salt into your body and prevents fluid from building up in the body."

Answered by AI

How long does Zestoretic take to work?

"If you are taking Zestoretic, you should see an improvement in your blood pressure after about two weeks. Be sure to tell your doctor about any throat irritation, rash, swelling in your lips, or abdominal pain that you experience, as these could be signs of an allergic reaction."

Answered by AI

Clinical Trials for Zestoretic

Have you considered Zestoretic clinical trials? We made a collection of clinical trials featuring Zestoretic, we think they might fit your search criteria.
Have you considered Zestoretic clinical trials? We made a collection of clinical trials featuring Zestoretic, we think they might fit your search criteria.
Have you considered Zestoretic clinical trials? We made a collection of clinical trials featuring Zestoretic, we think they might fit your search criteria.