Xigduo Xr

Hypesthesia, Hypesthesia, Hypesthesia + 13 more

Treatment

6 FDA approvals

20 Active Studies for Xigduo Xr

Treatment for

Hypesthesia

What is Xigduo Xr

DapagliflozinThe Generic name of this drug

Treatment SummaryMetformin is a medication used to treat type 2 diabetes. It helps lower blood sugar levels without causing low blood sugar, and can also lead to modest weight loss. It has been prescribed to over 120 million people worldwide, and is the preferred treatment for obese type 2 diabetes patients. Metformin was first approved in Canada in 1972 and in the United States in 1995. It comes in both regular and extended-release forms.

Farxigais the brand name

Xigduo Xr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Farxiga

Dapagliflozin

2008

Approved as Treatment by the FDA

Dapagliflozin, also known as Farxiga, is approved by the FDA for 6 uses such as Type 2 Diabetes Mellitus and Physical Activity .

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

Physical Activity

Used to treat Exercise in combination with Metformin

Diet

Used to treat Diet in combination with Metformin

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

Pharmaceutical Preparations

Used to treat previously treated with drugs in combination with Saxagliptin

inadequate response to monotherapy

Used to treat inadequate response to monotherapy in combination with Saxagliptin

Effectiveness

How Xigduo Xr Affects PatientsInsulin is an important hormone that helps to regulate the amount of glucose (sugar) in your blood. People with Type 2 diabetes either have trouble responding to insulin or do not produce enough of it. Metformin works by reducing the amount of glucose made in the liver, preventing its absorption in the intestines, and making it easier for cells to use insulin. Unlike other diabetes drugs, it does not increase the levels of insulin in the body. In a 29-week clinical trial, metformin lowered fasting plasma glucose levels by 59 mg/dL and HbA1c (measurement of glucose control)

How Xigduo Xr works in the bodyMetformin works to lower blood glucose levels by decreasing the production of glucose in the liver, blocking its absorption in the intestines, and making cells more sensitive to insulin. It enters cells and mitochondria, where it affects the production of ATP and activates an enzyme called AMPK. This enzyme prevents fat production and storage, while also blocking the production of chemical signals that increase glucose production. In the intestines, metformin increases anaerobic glucose metabolism, leading to less glucose being absorbed. It also promotes the metabolism of glucose by increasing another enzyme called GLP-1. How exactly metformin works is still being studied.

When to interrupt dosage

The proposed dosage of Xigduo Xr relies upon the diagnosed ailment, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The measure of dosage fluctuates with regards to the method of delivery (e.g. Oral or Tablet - Oral) featured in the table underneath.

Condition

Dosage

Administration

Physical Activity

, 5.0 mg, 10.0 mg, 2.5 mg