Votrient

Thyroid Neoplasms, Sarcoma, Kidney Neoplasms
Treatment
4 FDA approvals
20 Active Studies for Votrient

What is Votrient

PazopanibThe Generic name of this drug
Treatment SummaryPazopanib is a drug developed by GlaxoSmithKline and approved by the FDA in 2009. It works by blocking certain proteins that help cancer cells grow and divide, helping to slow or stop the growth of tumors.
Votrientis the brand name
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Votrient Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Votrient
Pazopanib
2009
3

Approved as Treatment by the FDA

Pazopanib, also known as Votrient, is approved by the FDA for 4 uses including advanced Soft Tissue Sarcoma (STS) and Advanced Renal Cell Carcinoma (aRCC) .
advanced Soft Tissue Sarcoma (STS)
Advanced Renal Cell Carcinoma (aRCC)
Sarcoma
Kidney Neoplasms

Effectiveness

How Votrient Affects PatientsPazopanib is a type of medication that reaches a high concentration in the body. This concentration is strong enough to stop a certain receptor from working, which can help reduce tumour size, stop tumour growth, and even cause tumour cells to die. It can also reduce how much blood flows to tumours and can lower the pressure inside tumours. All of these effects can be seen when patients are taking this medication.
How Votrient works in the bodyPazopanib is a drug that stops cancer from growing its own blood vessels. It does this by blocking certain proteins that help the cancer form new vessels. By stopping the formation of these vessels, the cancer is deprived of the nutrients it needs to grow and spread.

When to interrupt dosage

The recommended dosage of Votrient is contingent upon the diagnosed illness, such as advanced Soft Tissue Sarcoma (STS), Advanced Renal Cell Carcinoma (aRCC) and advanced Thyroid cancer. The measure of dosage fluctuates, in line with the technique of delivery detailed in the table beneath.
Condition
Dosage
Administration
Sarcoma
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Kidney Neoplasms
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Thyroid Neoplasms
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Votrient.
Common Votrient Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Pazopanib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Pazopanib.
Acteoside
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with Acteoside.
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Votrient Novel Uses: Which Conditions Have a Clinical Trial Featuring Votrient?

24 active trials are presently investigating the potential of Votrient to provide therapeutic benefit in cases of advanced Renal Cell Carcinoma (aRCC), advanced Thyroid Cancer and advanced Soft Tissue Sarcoma (STS).
Condition
Clinical Trials
Trial Phases
Thyroid Neoplasms
0 Actively Recruiting
Kidney Neoplasms
16 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
Sarcoma
5 Actively Recruiting
Phase 1, Phase 2, Phase 3

Votrient Reviews: What are patients saying about Votrient?

5Patient Review
4/23/2012
Votrient for Cancer Involving the Kidney Cells
Votrient has been working great for me, keeping my tumors stable or even shrinking them. I didn't have any problems with diarrhea until after the first six months, and that's really the only side effect I've noticed.
5Patient Review
1/2/2014
Votrient for Tumor of Soft/Connective Tissue that is Usually Malignant
While there have been some side effects, like chest pain and fatigue, this treatment has helped my daughter immensely. She was diagnosed with synovial sarcoma a year ago and has shown great progress since then.
5Patient Review
10/31/2011
Votrient for Cancer Involving the Kidney Cells
5Patient Review
8/14/2019
Votrient for Cancer Involving the Kidney Cells
Votrient has been a life-saver for me. I got the package from India, which was only 8% of the price in the US, and it worked just as well. After six months there were no signs of metastasis and I've been in remission since 2019. The only downside is that Votrient caused high blood pressure, but that was mitigated by Procardia. Recently I've lost weight and have been having some digestive issues.
4.3Patient Review
10/23/2013
Votrient for Tumor of Soft/Connective Tissue that is Usually Malignant
I've been on Pazopanib since 2011, after having my left kidney removed in 2009. I took a break from the medication for three months in 2012 to let my body recover, during which time the cancer spread to my left lung. However, I resumed taking 800mg per day and the tumors have stabilized since then. Despite the side effects (fatigue, diarrhea, tingling fingers, sore mouth, dryness), this medication allows me to live a relatively normal life and travel as often as I'd like.
View All Reviews
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Patient Q&A Section about votrient

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Votrient cure cancer?

"Votrient is a drug that can extend the amount of time a cancer patient lives without the disease progressing, and can also shrink or slow the growth of kidney cancer in some people. It is not however, a cure for cancer."

Answered by AI

How effective is Votrient?

"The drug Votrient was approved after a Phase III trial showed that it reduces the risk of tumor progression or death by 54% compared to placebo. The overall median progression-free survival was 9.2 months with Votrient compared to 4.2 months with placebo."

Answered by AI

Is Votrient chemotherapy?

"This knowledge has led to the development of new drugs that can more specifically target cancer cells.

Although Votrient is not a chemotherapy drug, it is a targeted therapy. Targeted therapy is a result of extensive research devoted to understanding the differences between cancer cells and normal cells. This research has led to the development of new drugs that can target cancer cells specifically."

Answered by AI

What is Votrient used to treat?

"VOTRIENT is a prescription medicine used to treat adults with advanced renal cell cancer (RCC) and soft tissue sarcoma (STS). VOTRIENT is taken as a tablet by mouth and is available in two strengths, 150 mg and 200 mg."

Answered by AI

Clinical Trials for Votrient

Have you considered Votrient clinical trials? We made a collection of clinical trials featuring Votrient, we think they might fit your search criteria.
Have you considered Votrient clinical trials? We made a collection of clinical trials featuring Votrient, we think they might fit your search criteria.
Have you considered Votrient clinical trials? We made a collection of clinical trials featuring Votrient, we think they might fit your search criteria.
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