Your session is about to expire
What is Votrient
PazopanibThe Generic name of this drug
Treatment SummaryPazopanib is a drug developed by GlaxoSmithKline and approved by the FDA in 2009. It works by blocking certain proteins that help cancer cells grow and divide, helping to slow or stop the growth of tumors.
Votrientis the brand name
Votrient Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Votrient
Pazopanib
2009
3
Approved as Treatment by the FDA
Pazopanib, also known as Votrient, is approved by the FDA for 2 uses including advanced Soft Tissue Sarcoma (STS) and Advanced Renal Cell Carcinoma (aRCC) .advanced Soft Tissue Sarcoma (STS)
Advanced Renal Cell Carcinoma (aRCC)
Effectiveness
How Votrient Affects PatientsPazopanib is a type of medication that reaches a high concentration in the body. This concentration is strong enough to stop a certain receptor from working, which can help reduce tumour size, stop tumour growth, and even cause tumour cells to die. It can also reduce how much blood flows to tumours and can lower the pressure inside tumours. All of these effects can be seen when patients are taking this medication.
How Votrient works in the bodyPazopanib is a drug that stops cancer from growing its own blood vessels. It does this by blocking certain proteins that help the cancer form new vessels. By stopping the formation of these vessels, the cancer is deprived of the nutrients it needs to grow and spread.
When to interrupt dosage
The recommended dosage of Votrient is contingent upon the diagnosed illness, such as advanced Soft Tissue Sarcoma (STS), Advanced Renal Cell Carcinoma (aRCC) and advanced Thyroid cancer. The measure of dosage fluctuates, in line with the technique of delivery detailed in the table beneath.Condition
Dosage
Administration
advanced Soft Tissue Sarcoma (STS)
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
advanced Thyroid cancer
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Advanced Renal Cell Carcinoma (aRCC)
, 400.0 mg, 200.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Votrient.Common Votrient Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Pazopanib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Pazopanib.
Acteoside
Major
The risk or severity of adverse effects can be increased when Pazopanib is combined with Acteoside.
Votrient Novel Uses: Which Conditions Have a Clinical Trial Featuring Votrient?
24 active trials are presently investigating the potential of Votrient to provide therapeutic benefit in cases of advanced Renal Cell Carcinoma (aRCC), advanced Thyroid Cancer and advanced Soft Tissue Sarcoma (STS).Condition
Clinical Trials
Trial Phases
advanced Thyroid cancer
0 Actively Recruiting
advanced Soft Tissue Sarcoma (STS)
8 Actively Recruiting
Phase 1, Phase 2, Phase 3
Advanced Renal Cell Carcinoma (aRCC)
16 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Votrient Reviews: What are patients saying about Votrient?
5Patient Review
4/23/2012 Votrient has been working great for me, keeping my tumors stable or even shrinking them. I didn't have any problems with diarrhea until after the first six months, and that's really the only side effect I've noticed.
5Patient Review
1/2/2014 While there have been some side effects, like chest pain and fatigue, this treatment has helped my daughter immensely. She was diagnosed with synovial sarcoma a year ago and has shown great progress since then.
5Patient Review
10/31/20115Patient Review
8/14/2019 Votrient has been a life-saver for me. I got the package from India, which was only 8% of the price in the US, and it worked just as well. After six months there were no signs of metastasis and I've been in remission since 2019. The only downside is that Votrient caused high blood pressure, but that was mitigated by Procardia. Recently I've lost weight and have been having some digestive issues.
4.3Patient Review
10/23/2013 I've been on Pazopanib since 2011, after having my left kidney removed in 2009. I took a break from the medication for three months in 2012 to let my body recover, during which time the cancer spread to my left lung. However, I resumed taking 800mg per day and the tumors have stabilized since then. Despite the side effects (fatigue, diarrhea, tingling fingers, sore mouth, dryness), this medication allows me to live a relatively normal life and travel as often as I'd like.
4.3Patient Review
5/19/20114Patient Review
4/19/2013 This treatment helped to reduce the spots in my lungs, but the side effects were not tolerable. I experienced black spots in my vision, which was the final straw. I'm now switching to a different medication.
3Patient Review
10/10/2017 I've been experiencing a lot of negative side effects, but my recent scans showed that the treatment is working. So I guess it's worth it?
3Patient Review
12/21/2011 Votrient has helped to shrink my metastatic lung growths, but the side effects are pretty constant diarrhea and high blood pressure.
1Patient Review
2/25/2018 I could only tolerate seven doses of this treatment before the side effects became too much for me to handle. I'm still recovering from mouth sores, hypertension, diarrhea, muscle and joint pain, and loss of taste several days later.
Patient Q&A Section about votrient
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can Votrient cure cancer?
"Votrient is a drug that can extend the amount of time a cancer patient lives without the disease progressing, and can also shrink or slow the growth of kidney cancer in some people. It is not however, a cure for cancer."
Answered by AI
How effective is Votrient?
"The drug Votrient was approved after a Phase III trial showed that it reduces the risk of tumor progression or death by 54% compared to placebo. The overall median progression-free survival was 9.2 months with Votrient compared to 4.2 months with placebo."
Answered by AI
Is Votrient chemotherapy?
"This knowledge has led to the development of new drugs that can more specifically target cancer cells.
Although Votrient is not a chemotherapy drug, it is a targeted therapy. Targeted therapy is a result of extensive research devoted to understanding the differences between cancer cells and normal cells. This research has led to the development of new drugs that can target cancer cells specifically."
Answered by AI
What is Votrient used to treat?
"VOTRIENT is a prescription medicine used to treat adults with advanced renal cell cancer (RCC) and soft tissue sarcoma (STS). VOTRIENT is taken as a tablet by mouth and is available in two strengths, 150 mg and 200 mg."
Answered by AI