Verelan

Cluster Headache, prophylaxis of Cluster headaches, Angina, Unstable + 7 more

Treatment

3 FDA approvals

20 Active Studies for Verelan

What is Verelan

Verapamil

The Generic name of this drug

Treatment Summary

Verapamil is a medication used to lower blood pressure, treat abnormal heart rhythms, and relieve chest pain. It was the first calcium channel blocker to be used in medical treatment and was introduced in the early 1960s. Verapamil is not related to other heart medications and is made up of two enantiomers (S- and R-) that have different levels of potency and metabolism rate.

Calan

is the brand name

image of different drug pills on a surface

Verelan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Calan

Verapamil

1984

357

Approved as Treatment by the FDA

Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .

Atrial Fibrillation or Flutter

Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril

Heart Rate

Used to treat Heart Rate in combination with Digitoxin

Effectiveness

How Verelan Affects Patients

Verapamil is a medicine used to treat abnormal heart rhythms, chest pain, and high blood pressure. It works by blocking calcium from entering the cells of the heart and blood vessels, which helps to reduce their activity. Short-acting versions of verapamil need to be taken 3-4 times a day, but there are extended-release versions that can be taken once a day. People with weakened hearts or thickened heart muscles should not take verapamil as it can worsen their condition.

How Verelan works in the body

Verapamil works by blocking certain calcium channels in the body. These channels, when open, allow for the contraction of muscles and the electrical signals necessary for the heart's pacemaker. By blocking these channels, verapamil reduces the contraction of blood vessels, lowering blood pressure and reducing the force against which the heart has to push. It also slows the electrical activity of the AV node, reducing heart rate. Verapamil may also target other calcium channels, potassium channels, and adrenergic receptors, but its exact mechanism of action in treating cluster headaches is unclear.

When to interrupt dosage

The amount of Verelan is contingent upon the diagnosed affliction, including Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The measure of dosage fluctuates as per the administration approach featured in the table beneath.

Condition

Dosage

Administration

Angina, Stable

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Vasospastic Angina

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Heart Rate

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

prophylaxis of Cluster headaches

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Angina, Unstable

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Cluster Headache

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Hypertensive disease

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Tachycardia, Ventricular

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Tachycardia, Supraventricular

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Atrial Fibrillation or Flutter

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral

Warnings

Verelan Contraindications

Condition

Risk Level

Notes

Atrioventricular Block

Do Not Combine

Ventricular Tachycardia

Do Not Combine

Atrial Fibrillation

Do Not Combine

Shock, Cardiogenic

Do Not Combine

accessory bypass tract

Do Not Combine

Heart Failure

Do Not Combine

Pulse Frequency

Do Not Combine

Sick Sinus Syndrome

Do Not Combine

Bradycardia

Do Not Combine

Hypotension

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Verapamil may interact with Pulse Frequency

There are 20 known major drug interactions with Verelan.

Common Verelan Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Verapamil.

Acepromazine

Major

Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Verapamil.

Alfuzosin

Major

Verapamil may increase the hypotensive activities of Alfuzosin.

Verelan Toxicity & Overdose Risk

The lowest toxic dose of verapamil for women is 14.4mg/kg and for men is 3.429mg/kg, while the highest toxic dose for rats is 150mg/kg and for mice is 163mg/kg. If someone overdoses on verapamil, there is no specific antidote, so treatment is mainly supportive. Symptoms of overdose usually include low blood pressure, slow heart rate, and abnormal heart rhythm, but there have been cases of fluid buildup in the lungs after taking very large doses (up to 9 grams). In cases of acute overdose, treatments may include drugs to empty the stomach, drugs to

image of a doctor in a lab doing drug, clinical research

Verelan Novel Uses: Which Conditions Have a Clinical Trial Featuring Verelan?

34 active studies are examining the potential of Verelan to manage Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).

Condition

Clinical Trials

Trial Phases

Cluster Headache

2 Actively Recruiting

Phase 1, Phase 2

Heart Rate

0 Actively Recruiting

Tachycardia, Supraventricular

2 Actively Recruiting

Phase 3, Phase 2

Angina, Unstable

2 Actively Recruiting

Not Applicable

prophylaxis of Cluster headaches

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Angina, Stable

0 Actively Recruiting

Atrial Fibrillation or Flutter

0 Actively Recruiting

Tachycardia, Ventricular

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Verelan Reviews: What are patients saying about Verelan?

4.7

Patient Review

2/5/2010

Verelan for High Blood Pressure

Overall, this treatment has helped me a lot. The only issue is that I sometimes feel like my heart skips a beat if I don't take it regularly.

4.7

Patient Review

2/1/2012

Verelan for Migraine Prevention

This medication has been effective in preventing migraines for me.

3.3

Patient Review

5/25/2011

Verelan for High Blood Pressure

I've been taking this for ten years now. The only real downside I've experienced is some dizziness, swelling in my ankles, and fatigue.

2

Patient Review

3/7/2012

Verelan for Migraine Prevention

Verelan unfortunately was not effective in preventing migraines for me, nor did it work well to lower my blood pressure.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about verelan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is verelan a calcium channel blocker?

"The active ingredient in Verelan is a drug that lowers blood pressure by reducing the force of the heart's contractions and relaxing the arteries."

Answered by AI

What is the brand name for verelan?

"These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including the class to which this drug principally belongs

There are three pharmacies near 94043 that have coupons for Calan SR (Brand Names:Verelan for 80MG). Verelan (verapamil HCl) is a medication used to treat hypertension, or high blood pressure. Lowering blood pressure reduces the risk of having a stroke or heart attack, which are two common cardiovascular events. Studies have shown that taking medications to lower blood pressure, like Verelan, can help reduce the risk of these events happening."

Answered by AI

What is verelan used to treat?

"Verapamil is a drug used to lower high blood pressure in order to prevent strokes, heart attacks, and kidney problems. it belongs to a class of drugs known as calcium channel blockers which work by relaxing blood vessels so blood can flow more easily."

Answered by AI

What is verapamil tablets used for?

"Verapamil is used to prevent chest pain caused by angina as well as irregular heart rhythms (arrhythmias). It's also used to treat high blood pressure (hypertension). If you have high blood pressure, taking verapamil helps to prevent future heart disease."

Answered by AI

Clinical Trials for Verelan

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

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Fasting for Myocardial Infarction

18+
All Sexes
Tampa, FL

The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to know whether eating and drinking before their procedure improves comfort without raising the risk of complications. The study will answer: * Does eating and drinking before the procedure improve patient comfort? * Does it increase the risk of adverse events like vomiting, aspiration (food or liquid entering the lungs), breathing problems, or death, etc? Participants will be randomly assigned to either: * A standard fasting group (no food for 6 hours, no clear liquids for 2 hours), or * A no-fasting group (able to eat and drink as usual). Patients will complete brief surveys before the procedure to assess comfort and satisfaction. Researchers will also review medical records weekly and 30 days later to monitor for safety outcomes.

Recruiting
Has No Placebo

Tampa General Hospital

Samip Vasaiwala, MD

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Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada

Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).

Phase 1
Recruiting

University of Alberta

Jianping Wu, PhD

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CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ

This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.

Recruiting
Has No Placebo

Northern Arizona University (+1 Sites)

Tochukwu Ikwunne, PhD

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