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What is Verelan
VerapamilThe Generic name of this drug
Treatment SummaryVerapamil is a medication used to lower blood pressure, treat abnormal heart rhythms, and relieve chest pain. It was the first calcium channel blocker to be used in medical treatment and was introduced in the early 1960s. Verapamil is not related to other heart medications and is made up of two enantiomers (S- and R-) that have different levels of potency and metabolism rate.
Calanis the brand name
Verelan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calan
Verapamil
1984
357
Approved as Treatment by the FDA
Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .Atrial Fibrillation or Flutter
Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril
Heart Rate
Used to treat Heart Rate in combination with Digitoxin
Effectiveness
How Verelan Affects PatientsVerapamil is a medicine used to treat abnormal heart rhythms, chest pain, and high blood pressure. It works by blocking calcium from entering the cells of the heart and blood vessels, which helps to reduce their activity. Short-acting versions of verapamil need to be taken 3-4 times a day, but there are extended-release versions that can be taken once a day. People with weakened hearts or thickened heart muscles should not take verapamil as it can worsen their condition.
How Verelan works in the bodyVerapamil works by blocking certain calcium channels in the body. These channels, when open, allow for the contraction of muscles and the electrical signals necessary for the heart's pacemaker. By blocking these channels, verapamil reduces the contraction of blood vessels, lowering blood pressure and reducing the force against which the heart has to push. It also slows the electrical activity of the AV node, reducing heart rate. Verapamil may also target other calcium channels, potassium channels, and adrenergic receptors, but its exact mechanism of action in treating cluster headaches is unclear.
When to interrupt dosage
The amount of Verelan is contingent upon the diagnosed affliction, including Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The measure of dosage fluctuates as per the administration approach featured in the table beneath.Condition
Dosage
Administration
Tachycardia, Ventricular
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Heart Rate
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Paroxysmal Supraventricular Tachycardia (PSVT)
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation or Flutter
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Cluster Headache
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
prophylaxis of Cluster headaches
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Unstable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Vasospastic Angina
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Tablet, coated, Tablet, coated - Oral
Warnings
Verelan ContraindicationsCondition
Risk Level
Notes
third degree AV block
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Atrial Fibrillation
Do Not Combine
Shock, Cardiogenic
Do Not Combine
accessory bypass tract
Do Not Combine
severe Left Ventricular Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Hypotension
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Verapamil may interact with Pulse Frequency
Common Verelan Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Verapamil.
Acepromazine
Major
Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Verapamil.
Alfuzosin
Major
Verapamil may increase the hypotensive activities of Alfuzosin.
Verelan Toxicity & Overdose RiskThe lowest toxic dose of verapamil for women is 14.4mg/kg and for men is 3.429mg/kg, while the highest toxic dose for rats is 150mg/kg and for mice is 163mg/kg. If someone overdoses on verapamil, there is no specific antidote, so treatment is mainly supportive. Symptoms of overdose usually include low blood pressure, slow heart rate, and abnormal heart rhythm, but there have been cases of fluid buildup in the lungs after taking very large doses (up to 9 grams). In cases of acute overdose, treatments may include drugs to empty the stomach, drugs to
Verelan Novel Uses: Which Conditions Have a Clinical Trial Featuring Verelan?
34 active studies are examining the potential of Verelan to manage Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).Condition
Clinical Trials
Trial Phases
prophylaxis of Cluster headaches
0 Actively Recruiting
Tachycardia, Ventricular
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
Unstable Angina Pectoris
0 Actively Recruiting
Vasospastic Angina
0 Actively Recruiting
Cluster Headache
4 Actively Recruiting
Phase 1, Phase 3, Phase 2
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Rate
1 Actively Recruiting
Not Applicable
Paroxysmal Supraventricular Tachycardia (PSVT)
2 Actively Recruiting
Phase 3, Phase 2
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Verelan Reviews: What are patients saying about Verelan?
4.7Patient Review
2/5/2010 Overall, this treatment has helped me a lot. The only issue is that I sometimes feel like my heart skips a beat if I don't take it regularly.
4.7Patient Review
2/1/2012 This medication has been effective in preventing migraines for me.
3.3Patient Review
5/25/2011 I've been taking this for ten years now. The only real downside I've experienced is some dizziness, swelling in my ankles, and fatigue.
2Patient Review
3/7/2012 Verelan unfortunately was not effective in preventing migraines for me, nor did it work well to lower my blood pressure.
Patient Q&A Section about verelan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is verelan a calcium channel blocker?
"The active ingredient in Verelan is a drug that lowers blood pressure by reducing the force of the heart's contractions and relaxing the arteries."
Answered by AI
What is the brand name for verelan?
"These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including the class to which this drug principally belongs
There are three pharmacies near 94043 that have coupons for Calan SR (Brand Names:Verelan for 80MG). Verelan (verapamil HCl) is a medication used to treat hypertension, or high blood pressure. Lowering blood pressure reduces the risk of having a stroke or heart attack, which are two common cardiovascular events. Studies have shown that taking medications to lower blood pressure, like Verelan, can help reduce the risk of these events happening."
Answered by AI
What is verelan used to treat?
"Verapamil is a drug used to lower high blood pressure in order to prevent strokes, heart attacks, and kidney problems. it belongs to a class of drugs known as calcium channel blockers which work by relaxing blood vessels so blood can flow more easily."
Answered by AI
What is verapamil tablets used for?
"Verapamil is used to prevent chest pain caused by angina as well as irregular heart rhythms (arrhythmias). It's also used to treat high blood pressure (hypertension). If you have high blood pressure, taking verapamil helps to prevent future heart disease."
Answered by AI