Verapamil Hydrochloride

Cluster Headache, prophylaxis of Cluster headaches, Angina, Unstable + 7 more

Treatment

3 FDA approvals

20 Active Studies for Verapamil Hydrochloride

What is Verapamil Hydrochloride

Verapamil

The Generic name of this drug

Treatment Summary

Verapamil is a medication used to lower high blood pressure, treat heart rhythm problems, and relieve chest pain. It was first used in the 1960s and is part of a class of drugs called non-dihydropyridine calcium channel blockers. The drug is composed of two parts, the S-enantiomer and R-enantiomer, each of which has different levels of potency and is processed at different rates.

Calan

is the brand name

image of different drug pills on a surface

Verapamil Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Calan

Verapamil

1984

357

Approved as Treatment by the FDA

Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .

Atrial Fibrillation or Flutter

Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril

Heart Rate

Used to treat Heart Rate in combination with Digitoxin

Effectiveness

How Verapamil Hydrochloride Affects Patients

Verapamil is a type of drug that helps to regulate the heart beat, reduce chest pain, and lower blood pressure. It comes in an immediate-release form that needs to be taken 3 or 4 times a day and an extended-release form that can be taken once daily. However, it does decrease the strength of the heart muscle, so it should not be used by people with weakened heart muscles or hypertrophic cardiomyopathy.

How Verapamil Hydrochloride works in the body

Verapamil works by blocking calcium channels in the heart, blood vessels, and other cells. This blocks the influx of calcium, causing the blood vessels to relax, reducing blood pressure and the load on the heart. It also slows the electrical activity of the heart, helping to stabilize a racing heart. It's possible that verapamil also works on other types of calcium channels, potassium channels, and adrenergic receptors, but this isn't clear.

When to interrupt dosage

The advised dose of Verapamil Hydrochloride is based upon the diagnosed condition, including Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The portion of dosage depends upon the proposed methodology of delivery, as featured in the table underneath.

Condition

Dosage

Administration

Vasospastic Angina

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Angina, Stable

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Heart Rate

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

prophylaxis of Cluster headaches

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Angina, Unstable

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Cluster Headache

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Hypertensive disease

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Tachycardia, Ventricular

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Tachycardia, Supraventricular

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Atrial Fibrillation or Flutter

180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral

Warnings

Verapamil Hydrochloride Contraindications

Condition

Risk Level

Notes

Atrioventricular Block

Do Not Combine

Ventricular Tachycardia

Do Not Combine

Atrial Fibrillation

Do Not Combine

Shock, Cardiogenic

Do Not Combine

accessory bypass tract

Do Not Combine

Heart Failure

Do Not Combine

Pulse Frequency

Do Not Combine

Sick Sinus Syndrome

Do Not Combine

Bradycardia

Do Not Combine

Hypotension

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Verapamil may interact with Pulse Frequency

There are 20 known major drug interactions with Verapamil Hydrochloride.

Common Verapamil Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Verapamil.

Acepromazine

Major

Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Verapamil.

Alfuzosin

Major

Verapamil may increase the hypotensive activities of Alfuzosin.

Verapamil Hydrochloride Toxicity & Overdose Risk

The toxic dose of verapamil in women is 14.4mg/kg and 3.429mg/kg in men. The lethal dose in rats is 150mg/kg and 163mg/kg in mice. There is no antidote for an overdose of verapamil, so treatment focuses on providing supportive care. Symptoms of an overdose may include low blood pressure, slow heart rate, and irregular heartbeat. Patients who have taken a large overdose (up to 9 grams) may experience non-cardiogenic pulmonary edema. To treat an overdose, doctors may recommend gastrointestinal decontamination, cathartics, or bowel irrigation

image of a doctor in a lab doing drug, clinical research

Verapamil Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Verapamil Hydrochloride?

34 active clinical trials are currently being conducted to evaluate the effectiveness of Verapamil Hydrochloride in alleviating Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).

Condition

Clinical Trials

Trial Phases

Cluster Headache

2 Actively Recruiting

Phase 1, Phase 2

Heart Rate

0 Actively Recruiting

Tachycardia, Supraventricular

2 Actively Recruiting

Phase 3, Phase 2

Angina, Unstable

2 Actively Recruiting

Not Applicable

prophylaxis of Cluster headaches

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Angina, Stable

0 Actively Recruiting

Atrial Fibrillation or Flutter

0 Actively Recruiting

Tachycardia, Ventricular

0 Actively Recruiting

Hypertensive disease

28 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Verapamil Hydrochloride Reviews: What are patients saying about Verapamil Hydrochloride?

5

Patient Review

5/13/2022

Verapamil Hydrochloride for Prevention of Paroxysmal Supraventricular Tachycardia

I've been taking Verapamil Hydrochloride for about 10 years now, and it's been working great. I don't have any noticeable side effects, and if I miss a dose or two I'm likely to trigger an episode of SVT. So far so good, and unless a new treatment is developed, I expect to be on this medication for life.

5

Patient Review

5/23/2020

Verapamil Hydrochloride for High Blood Pressure

I've been taking Verapamil for over 15 years and it works great for me. I don't have any of the nasty side effects that I experienced with other blood pressure medications.

5

Patient Review

1/18/2020

Verapamil Hydrochloride for Migraine Prevention

I've been using verapamil for migraines for over 30 years with great results; no headaches in years. It's cheap and effective, and has also helped to keep my blood pressure at normal levels. The only downside is that every insurance company or doctor I see thinks I have a high blood pressure problem because of the medication, so I have to explain why I'm taking it.

5

Patient Review

5/14/2019

Verapamil Hydrochloride for High Blood Pressure

I've been on verapamil for 16 years and it's great. It's also very affordable, which is awesome. I sometimes take an extra dose when I have atrial fibrillation and it really helps to calm my heart rate down.

5

Patient Review

11/13/2021

Verapamil Hydrochloride for Prevention of Paroxysmal Supraventricular Tachycardia

I've been struggling with heart palpitations for a few years now and have tried a couple different treatments. This one, Verapamil, has really worked well for me. I don't have nearly as many episodes and the side effects are manageable.

4

Patient Review

2/20/2016

Verapamil Hydrochloride for High Blood Pressure

I was discharged from the hospital after taking 480mg of this medication. However, I began to experience a pounding sensation in my head. I lowered the dosage to 240mg and it worked for a while, but the pounding came back. I then lowered it to 120mg and it worked for a while again, but the pounding came back. In addition, I was also taking 50mg of metoprolol with verapamil. I continued to experience an extreme pulse-like sensation in my head despite all of this. My doctor offered no relief.

4

Patient Review

9/9/2016

Verapamil Hydrochloride for Cluster Headache Prevention

I'm not sure if this is the cause, but I've been having issues with edema since starting this medication.

3.7

Patient Review

12/22/2015

Verapamil Hydrochloride for Prevention of Paroxysmal Supraventricular Tachycardia

3.3

Patient Review

5/12/2016

Verapamil Hydrochloride for Migraine Prevention

After many scans and tests, my new cardiologist prescribed this medication. It worked in the sense that I no longer felt like passing out, but it didn't do much to lower my blood pressure (178/82).

2.7

Patient Review

8/16/2017

Verapamil Hydrochloride for High Blood Pressure

I'm still taking a low dosage, but what I have experienced so far is that it has alleviated my depression and heart palpitations.

2.3

Patient Review

5/17/2018

Verapamil Hydrochloride for High Blood Pressure

The side effects of this medication were really awful. I experienced strange noises in my stomach, bowel incontinence, and constipation. It took me about six months to recover from taking this drug, and even then my innards were permanently changed. Now I have to take miralax every day.

2

Patient Review

1/12/2017

Verapamil Hydrochloride for Migraine Prevention

Verapamil is one of the only medications I can take without having an allergic reaction. It's effective at reducing my heart rate from 35 to 100 bpm.

1.7

Patient Review

1/26/2019

Verapamil Hydrochloride for High Blood Pressure

This didn't work for me at all.

1.7

Patient Review

11/11/2021

Verapamil Hydrochloride for High Blood Pressure

I had to use suppositories after this treatment froze my large intestine. It was a very unpleasant experience that I wouldn't wish on anyone.

1

Patient Review

1/3/2016

Verapamil Hydrochloride for High Blood Pressure

1

Patient Review

10/15/2017

Verapamil Hydrochloride for Migraine Prevention

I would not recommend this drug to anyone due to the laundry list of terrible side effects I experienced. They range from constipation and dry eyes/mouth to swelling extremities, weight gain, hair loss, and numbness/tingling in the hands/face/lower body. I was taking it for migraines but ended up with chronic insomnia and then central sleep apnea (of unknown cause). The longer I took the medication, the more problems arose.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about verapamil hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is verapamil hydrochloride?

"Verapamil is a type of medication known as a calcium-channel blocker. It works by relaxing the blood vessels, which reduces the amount of work the heart has to do."

Answered by AI

How long does verapamil take to work?

"Verapamil reaches peak levels in the bloodstream one to two hours after it is taken orally. Its peak levels may be higher in people with liver disease or who are older."

Answered by AI

What is verapamil hydrochloride used for?

"Verapamil is used to prevent chest pain caused by angina as well as irregular heart rhythms (arrhythmias). It's also used to treat high blood pressure (hypertension). If you have high blood pressure, taking verapamil will help to prevent future heart disease."

Answered by AI

What is verapamil side effects?

"If you experience any of the following symptoms, you may be suffering from heart failure: blue lips and fingernails, chest pain, coughing that sometimes produces a pink frothy sputum, difficult, fast, noisy breathing, sometimes with wheezing, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, lightheadedness, dizziness, or fainting, shortness of breath."

Answered by AI

Clinical Trials for Verapamil Hydrochloride

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Have you considered Verapamil Hydrochloride clinical trials?

We made a collection of clinical trials featuring Verapamil Hydrochloride, we think they might fit your search criteria.
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Image of Tampa General Hospital in Tampa, United States.

Fasting for Myocardial Infarction

18+
All Sexes
Tampa, FL

The goal of this clinical trial is to find out whether fasting is necessary before urgent inpatient cardiac catheterizations. For patients presenting with urgent heart-related pain or even mild heart attacks, researchers want to know whether eating and drinking before their procedure improves comfort without raising the risk of complications. The study will answer: * Does eating and drinking before the procedure improve patient comfort? * Does it increase the risk of adverse events like vomiting, aspiration (food or liquid entering the lungs), breathing problems, or death, etc? Participants will be randomly assigned to either: * A standard fasting group (no food for 6 hours, no clear liquids for 2 hours), or * A no-fasting group (able to eat and drink as usual). Patients will complete brief surveys before the procedure to assess comfort and satisfaction. Researchers will also review medical records weekly and 30 days later to monitor for safety outcomes.

Recruiting
Has No Placebo

Tampa General Hospital

Samip Vasaiwala, MD

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Text Message Reminders for High Blood Pressure

18+
All Sexes
Detroit, MI

This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center involves separate but related projects that aim to improve cardiometabolic health outcomes through better risk factor control for three chronic conditions that are of tremendous public health importance, (hypertension (HTN), heart failure, and coronary heart disease), all of which contribute significantly to premature death in Detroit and Cleveland. The present study is the prospective observational cohort component of ACHIEVE P1- EPI (Project 1) of the ACHIEVE GREATER Center and serves to characterize the population of patients with blood pressure (BP) levels above normal attending The Wayne Health Mobile Health Unit (MHU) events to better understand key factors (e.g., social determinants of health) that convey information about baseline BP levels and related clinical outcomes (e.g., follow-up clinic visits, BP control, and cardiovascular events).

Recruiting
Has No Placebo

Wayne Health Mobile Units

Steven J Korzeniewski, PhD

Image of University of Alberta in Edmonton, Canada.

Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada

Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).

Phase 1
Waitlist Available

University of Alberta

Jianping Wu, PhD

Image of Northern Arizona University in Flagstaff, United States.

CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ

This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.

Recruiting
Has No Placebo

Northern Arizona University (+1 Sites)

Tochukwu Ikwunne, PhD

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