Valsartan

Hypesthesia, Hypesthesia, Hypesthesia + 15 more
Treatment
11 FDA approvals
20 Active Studies for Valsartan

What is Valsartan

ValsartanThe Generic name of this drug
Treatment SummaryValsartan is a medication used to treat high blood pressure, heart failure, and kidney damage caused by diabetes. It is part of the angiotensin II receptor blocker (ARB) family of drugs, which works by blocking the activity of a protein called angiotensin II. This protein causes blood vessels to narrow, leading to higher blood pressure. By blocking its activity, valsartan helps lower blood pressure and reduce the risk of heart attack and stroke. It is usually well tolerated and has a lower risk for side effects compared to other antihypertensive drugs. Valsartan was approved in 1996 in Europe
Diovanis the brand name
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Valsartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diovan
Valsartan
1996
621

Approved as Treatment by the FDA

Valsartan, also known as Diovan, is approved by the FDA for 11 uses such as Heart failure and Moderate Essential Hypertension .
Heart failure
Used to treat Heart Failure in combination with Sacubitril
Moderate Essential Hypertension
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
chronic heart failure with reduced ejection fraction (NYHA Class II-IV)
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Heart Failure
Used to treat hospitalization due to cardiac failure in combination with Sacubitril
Systolic Left Ventricular Dysfunction
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril
High Blood Pressure
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
Combined Modality Therapy
Used to treat patients for whom combination therapy is appropriate in combination with Hydrochlorothiazide
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Sacubitril
Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
Congestive Heart Failure
Used to treat Heart Failure in combination with Sacubitril
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril

Effectiveness

How Valsartan Affects PatientsValsartan helps to control blood pressure by blocking the effects of a hormone (angiotensin II). It usually takes an oral dose of 80mg to reduce blood pressure by around 80%. The use of valsartan can lead to a slight decrease in cholesterol, triglycerides, glucose, and uric acid. Low blood pressure can be a side effect of valsartan, especially in patients who are already low in salt or taking high doses of diuretics. People with heart failure may also experience low blood pressure when taking valsartan, but usually it is not severe. If low blood pressure does occur
How Valsartan works in the bodyValsartan is a drug that belongs to a family of medications called angiotensin II receptor blockers (ARBs). It works by blocking the receptor that angiotensin II binds to in order to control blood pressure and reduce inflammation. This helps to lower the amount of stress on the heart, improve cardiac function, and reduce the chances of a heart attack or stroke. Valsartan is used to treat high blood pressure, heart failure, and complications related to diabetes and kidney disease. It can also be used to slow the progression of kidney disease. Valsartan has a much higher affinity for the AT1 receptor

When to interrupt dosage

The prescribed measure of Valsartan is contingent upon the determined illness, such as initial treatment, Left Ventricular Failure, Unspecified and Combined Modality Therapy. The amount of dosage is contingent upon the method of delivery (e.g. Tablet - Oral or Tablet, film coated) featured in the table beneath.
Condition
Dosage
Administration
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Diabetic Nephropathies
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Congestive Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Type 2 Diabetes
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
High Blood Pressure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Cardiovascular Mortality
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypertensive disease
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Combined Modality Therapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
initial treatment
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
multiple antihypertensive drugs likely required
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
not adequately controlled with monotherapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Failure, Unspecified
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral

Warnings

Valsartan Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valsartan may interact with Pulse Frequency
There are 20 known major drug interactions with Valsartan.
Common Valsartan Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Valsartan.
Amifostine
Major
Valsartan may increase the hypotensive activities of Amifostine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valsartan.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valsartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valsartan.
Valsartan Toxicity & Overdose RiskThe highest dose of valsartan that is considered toxic to rats is greater than 2000mg/kg. Studies on pregnant mice, rats, and rabbits showed no evidence of birth defects, but there were decreases in fetal weight, pup birth weight, pup survival rate, and delays in developmental milestones when the mother was given a maternally toxic dose of valsartan (600mg/kg/day) during organogenesis or late gestation and lactation. If pregnancy is detected while taking valsartan, it should be stopped as soon as possible.
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Valsartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Valsartan?

510 active clinical trials are presently investigating the potential of Valsartan to ameliorate Type 2 Diabetes, Diabetic Nephropathy and Hypertension.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
178 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Diabetic Nephropathies
0 Actively Recruiting
Ventricular Dysfunction, Left
1 Actively Recruiting
Phase 2, Phase 3
High Blood Pressure
4 Actively Recruiting
Not Applicable, Early Phase 1
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Hypesthesia
2 Actively Recruiting
Not Applicable
Cardiovascular Mortality
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Ventricular Dysfunction, Left
0 Actively Recruiting
Combined Modality Therapy
0 Actively Recruiting
Heart Failure
0 Actively Recruiting
Left Ventricular Failure, Unspecified
0 Actively Recruiting
Hypesthesia
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
initial treatment
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Valsartan Reviews: What are patients saying about Valsartan?

5Patient Review
11/29/2017
Valsartan for High Blood Pressure
4Patient Review
1/3/2018
Valsartan for High Blood Pressure
3.7Patient Review
5/12/2018
Valsartan for High Blood Pressure
I felt like I was retaining water after taking valssrtan. Within two weeks, I had gained ten pounds and experienced extreme headaches and swollen fingers. After stopping the medication cold turkey, I contacted my doctor. Additionally, while on the medication I would feel short of breath and experience weakness in my arms and hips.
3.7Patient Review
9/4/2019
Valsartan for High Blood Pressure
Although I generally had good outcomes, I was worried about the amount of weight gain.
3Patient Review
9/21/2019
Valsartan for High Blood Pressure
This medication led to a loss of control over my bladder and bowels. I would have to get up multiple times per night, and even after discontinuing the medication, I still experience these effects albeit less frequently.
View All Reviews
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Patient Q&A Section about valsartan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is valsartan?

"Valsartan is a drug that helps to lower blood pressure by blocking the tightening of blood vessels. This increased blood flow and oxygen to the heart."

Answered by AI

What should you not take with valsartan?

"Some drugs may interact with Tadalafil resulting in reduced effectiveness or increased side effects. These are:

-Certain diuretics -Ritonavir -Cyclosporine -Rifampin -Nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin or meloxicam"

Answered by AI

What are side effects of valsartan?

"The following are symptoms of kidney failure: bloody urine, decreased frequency or amount of urine, difficult breathing, dizziness, faintness, or lightheadedness when getting up from a lying position, increased thirst, irregular heartbeat, numbness or tingling in the hands, feet, or lips, swelling of the face, fingers, or lower legs."

Answered by AI

What is the best time to take valsartan?

"Most people will take valsartan once or twice per day. The recommended time to take the first dose is before bedtime, as it can cause dizziness. After the first dose, valsartan can be taken at any time, although it is best to take it at the same time each day."

Answered by AI

Clinical Trials for Valsartan

Have you considered Valsartan clinical trials? We made a collection of clinical trials featuring Valsartan, we think they might fit your search criteria.
Have you considered Valsartan clinical trials? We made a collection of clinical trials featuring Valsartan, we think they might fit your search criteria.
Have you considered Valsartan clinical trials? We made a collection of clinical trials featuring Valsartan, we think they might fit your search criteria.
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