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What is Valsartan
ValsartanThe Generic name of this drug
Treatment SummaryValsartan is a medication used to treat high blood pressure, heart failure, and kidney damage caused by diabetes. It is part of the angiotensin II receptor blocker (ARB) family of drugs, which works by blocking the activity of a protein called angiotensin II. This protein causes blood vessels to narrow, leading to higher blood pressure. By blocking its activity, valsartan helps lower blood pressure and reduce the risk of heart attack and stroke. It is usually well tolerated and has a lower risk for side effects compared to other antihypertensive drugs. Valsartan was approved in 1996 in Europe
Diovanis the brand name
Valsartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diovan
Valsartan
1996
621
Approved as Treatment by the FDA
Valsartan, also known as Diovan, is approved by the FDA for 7 uses such as Hypesthesia and hospitalization due to cardiac failure .Hypesthesia
Used to treat chronic heart failure with reduced ejection fraction (NYHA Class II-IV) in combination with Sacubitril
hospitalization due to cardiac failure
Used to treat hospitalization due to cardiac failure in combination with Sacubitril
High Blood Pressure
Used to treat Moderate Essential Hypertension in combination with Hydrochlorothiazide
Ventricular Dysfunction, Left
Used to treat Systolic Left Ventricular Dysfunction in combination with Sacubitril
Cardiovascular Mortality
Used to treat Cardiovascular Mortality in combination with Sacubitril
Combined Modality Therapy
Used to treat patients for whom combination therapy is appropriate in combination with Hydrochlorothiazide
Congestive Heart Failure
Used to treat Heart Failure in combination with Sacubitril
Effectiveness
How Valsartan Affects PatientsValsartan helps to control blood pressure by blocking the effects of a hormone (angiotensin II). It usually takes an oral dose of 80mg to reduce blood pressure by around 80%. The use of valsartan can lead to a slight decrease in cholesterol, triglycerides, glucose, and uric acid. Low blood pressure can be a side effect of valsartan, especially in patients who are already low in salt or taking high doses of diuretics. People with heart failure may also experience low blood pressure when taking valsartan, but usually it is not severe. If low blood pressure does occur
How Valsartan works in the bodyValsartan is a drug that belongs to a family of medications called angiotensin II receptor blockers (ARBs). It works by blocking the receptor that angiotensin II binds to in order to control blood pressure and reduce inflammation. This helps to lower the amount of stress on the heart, improve cardiac function, and reduce the chances of a heart attack or stroke. Valsartan is used to treat high blood pressure, heart failure, and complications related to diabetes and kidney disease. It can also be used to slow the progression of kidney disease. Valsartan has a much higher affinity for the AT1 receptor
When to interrupt dosage
The prescribed measure of Valsartan is contingent upon the determined illness, such as initial treatment, Left Ventricular Failure, Unspecified and Combined Modality Therapy. The amount of dosage is contingent upon the method of delivery (e.g. Tablet - Oral or Tablet, film coated) featured in the table beneath.Condition
Dosage
Administration
Congestive Heart Failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
not adequately controlled with monotherapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Type 2 Diabetes
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Failure, Unspecified
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
High Blood Pressure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypertensive disease
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Combined Modality Therapy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
multiple antihypertensive drugs likely required
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
initial treatment
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Ventricular Dysfunction, Left
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Hypesthesia
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Left Ventricular Dysfunction
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Cardiovascular Mortality
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
hospitalization due to cardiac failure
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Diabetic Nephropathy
160.0 mg, 320.0 mg, , 80.0 mg, 40.0 mg, 1.6 mg, 3.2 mg, 26.0 mg, 51.0 mg, 103.0 mg, 4.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral
Warnings
Valsartan ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Valsartan may interact with Pulse Frequency
Common Valsartan Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Valsartan.
Amifostine
Major
Valsartan may increase the hypotensive activities of Amifostine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Valsartan.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Valsartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Valsartan.
Valsartan Toxicity & Overdose RiskThe highest dose of valsartan that is considered toxic to rats is greater than 2000mg/kg. Studies on pregnant mice, rats, and rabbits showed no evidence of birth defects, but there were decreases in fetal weight, pup birth weight, pup survival rate, and delays in developmental milestones when the mother was given a maternally toxic dose of valsartan (600mg/kg/day) during organogenesis or late gestation and lactation. If pregnancy is detected while taking valsartan, it should be stopped as soon as possible.
Valsartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Valsartan?
510 active clinical trials are presently investigating the potential of Valsartan to ameliorate Type 2 Diabetes, Diabetic Nephropathy and Hypertension.Condition
Clinical Trials
Trial Phases
initial treatment
0 Actively Recruiting
Combined Modality Therapy
0 Actively Recruiting
Cardiovascular Mortality
0 Actively Recruiting
hospitalization due to cardiac failure
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Ventricular Dysfunction, Left
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
High Blood Pressure
0 Actively Recruiting
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Hypesthesia
4 Actively Recruiting
Not Applicable
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
multiple antihypertensive drugs likely required
0 Actively Recruiting
Left Ventricular Failure, Unspecified
0 Actively Recruiting
Hypesthesia
0 Actively Recruiting
Left Ventricular Dysfunction
6 Actively Recruiting
Not Applicable, Phase 4
Valsartan Reviews: What are patients saying about Valsartan?
5Patient Review
11/29/20174Patient Review
1/3/20183.7Patient Review
5/12/2018 I felt like I was retaining water after taking valssrtan. Within two weeks, I had gained ten pounds and experienced extreme headaches and swollen fingers. After stopping the medication cold turkey, I contacted my doctor. Additionally, while on the medication I would feel short of breath and experience weakness in my arms and hips.
3.7Patient Review
9/4/2019 Although I generally had good outcomes, I was worried about the amount of weight gain.
3Patient Review
9/21/2019 This medication led to a loss of control over my bladder and bowels. I would have to get up multiple times per night, and even after discontinuing the medication, I still experience these effects albeit less frequently.
3Patient Review
4/17/2018 This medication has been successful in keeping my blood pressure at a healthy level for the past year. I have experienced no negative side effects and am overall very satisfied with it.
3Patient Review
9/8/2018 This medication did not help to control my blood pressure at all. If anything, it made it more erratic.
2.7Patient Review
3/6/2022 After just ten days of use, I experienced shortness of breath, blurred vision, and pain in my left side. Additionally, brain fog made me feel forgetful and off balance.
2.7Patient Review
6/2/2022 This lowered my blood pressure but unfortunately also came with a host of nasty side effects, like body aches and an upset stomach. I had to switch to losartan 50 mg after only taking valsartan 120 mg for one month.
1.7Patient Review
2/8/2019 I was prescribed this medication for high blood pressure, but it didn't work at all. My pressure remained the same after one week of use. I'm now looking for a new physician.
1.7Patient Review
3/23/2022 While this medication does help to lower my blood pressure, the side effects are very difficult to deal with. I suffer from fatigue, insomnia, lack of concentration, and leg pain (among other things) as a result of taking this medication. Last night, I skipped taking it and was able to sleep just fine--so I'm hoping my doctor will be willing to make a change.
1.7Patient Review
5/17/2022 I stopped taking Valsartan a week ago and I feel SO much better. Dizziness was a big problem for me before, but it's gone now and I feel like a new person.
1Patient Review
7/17/2018 I am a 78-year-old woman with high blood pressure. This medication was very effective at reducing my BP, but I experienced daily back pain as a result. I will be getting off of it when a good replacement can be found.
1Patient Review
12/25/2019 I started experiencing pain after only two months of taking this medication. Additionally, I had an episode where my heart gave me a hard shock and I lost my breath. I was unable to move for about ten minutes. Once I was able to regain movement, I sought medical help and discontinue the use of this drug.
1Patient Review
4/6/2018Patient Q&A Section about valsartan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is valsartan?
"Valsartan is a drug that helps to lower blood pressure by blocking the tightening of blood vessels. This increased blood flow and oxygen to the heart."
Answered by AI
What should you not take with valsartan?
"Some drugs may interact with Tadalafil resulting in reduced effectiveness or increased side effects. These are:
-Certain diuretics -Ritonavir -Cyclosporine -Rifampin -Nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin or meloxicam"
Answered by AI
What are side effects of valsartan?
"The following are symptoms of kidney failure: bloody urine, decreased frequency or amount of urine, difficult breathing, dizziness, faintness, or lightheadedness when getting up from a lying position, increased thirst, irregular heartbeat, numbness or tingling in the hands, feet, or lips, swelling of the face, fingers, or lower legs."
Answered by AI
What is the best time to take valsartan?
"Most people will take valsartan once or twice per day. The recommended time to take the first dose is before bedtime, as it can cause dizziness. After the first dose, valsartan can be taken at any time, although it is best to take it at the same time each day."
Answered by AI