What is Ultram
TramadolThe Generic name of this drug
Treatment SummaryTramadol is a medication used to treat moderate to severe pain. It works differently than other opioid pain medications because it affects two types of neurotransmitters, serotonin and norepinephrine. This dual-action makes tramadol more effective at reducing pain from a variety of sources such as neuropathic pain, post-operative pain, lower back pain, labor pain, and cancer-related pain. It can also help with anxiety, depression, and shivering. Tramadol does carry a risk of side effects, including tolerance, dependence, abuse, and overdose. It can also cause seizures and serotonin syndrome if taken with
Ultramis the brand name
Ultram Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ultram
Tramadol
1995
475
Approved as Treatment by the FDA
Tramadol, otherwise called Ultram, is approved by the FDA for 1 uses including Acute Pain .Acute Pain
Used to treat Pain, Acute in combination with Acetaminophen
Effectiveness
How Ultram Affects PatientsTramadol is a pain reliever that works by binding to opioid receptors in the central nervous system. It can help reduce pain and fever, but can also lead to dizziness, drowsiness, nausea, constipation, sweating, and itching. It does not cause histamine release like morphine, has no effect on heart rate or left-ventricular function, and can cause respiratory depression and suppress coughing. Seizures have been reported with tramadol, especially when taken in high doses. It also carries a risk of serotonin syndrome when taken with other drugs that affect serotonin levels. Gastrointestinal effects of taking
How Ultram works in the bodyTramadol is a medicine that works on the brain to control pain. It has a weak connection to opioid receptors, and it also helps to increase the amount of serotonin and norepinephrine in the brain. It is made up of two parts that work together to provide pain relief. One part binds to opioid receptors, while the other part helps keep serotonin and norepinephrine in the brain. Tramadol also affects a number of other pain modulators, including alpha2-adrenoreceptors, neurokinin 1 receptors, voltage-gated sodium channels, transient receptor potential cation channels, muscar
When to interrupt dosage
The recommended measure of Ultram is contingent upon the diagnosed affliction, including Pain, Pain and Acute Pain. The amount of dosage may differ as per the prescribed method of delivery (e.g. Capsule or Tablet) stated in the table below.Condition
Dosage
Administration
Pain
200.0 mg, 300.0 mg, 100.0 mg, , 5.8 mg/mg, 400.0 mg, 150.0 mg, 5.0 mg/mg, 50.0 mg, 5.0 mg/mL, 44.0 mg, 37.5 mg, 75.0 mg, 0.5 mg, 1.0 mg/mg, 1.0 mg/mL
Capsule, Tablet, Capsule, extended release - Oral, Oral, Tablet, extended release - Oral, Tablet, film coated, extended release, , Tablet, extended release, Tablet, coated, Tablet, delayed release - Oral, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, delayed release, Tablet - Oral, Cream, Tablet, film coated, Capsule, extended release, Kit - Oral, Kit, Capsule, coated, extended release, Tablet, film coated, extended release - Oral, Capsule - Oral, Tablet, film coated - Oral, Tablet, orally disintegrating, Topical, Capsule, coated, extended release - Oral, Solution, Solution - Oral, Cream - Topical
Pain
200.0 mg, 300.0 mg, 100.0 mg, , 5.8 mg/mg, 400.0 mg, 150.0 mg, 5.0 mg/mg, 50.0 mg, 5.0 mg/mL, 44.0 mg, 37.5 mg, 75.0 mg, 0.5 mg, 1.0 mg/mg, 1.0 mg/mL
Capsule, Tablet, Capsule, extended release - Oral, Oral, Tablet, extended release - Oral, Tablet, film coated, extended release, , Tablet, extended release, Tablet, coated, Tablet, delayed release - Oral, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, delayed release, Tablet - Oral, Cream, Tablet, film coated, Capsule, extended release, Kit - Oral, Kit, Capsule, coated, extended release, Tablet, film coated, extended release - Oral, Capsule - Oral, Tablet, film coated - Oral, Tablet, orally disintegrating, Topical, Capsule, coated, extended release - Oral, Solution, Solution - Oral, Cream - Topical
Pain
200.0 mg, 300.0 mg, 100.0 mg, , 5.8 mg/mg, 400.0 mg, 150.0 mg, 5.0 mg/mg, 50.0 mg, 5.0 mg/mL, 44.0 mg, 37.5 mg, 75.0 mg, 0.5 mg, 1.0 mg/mg, 1.0 mg/mL
Capsule, Tablet, Capsule, extended release - Oral, Oral, Tablet, extended release - Oral, Tablet, film coated, extended release, , Tablet, extended release, Tablet, coated, Tablet, delayed release - Oral, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, delayed release, Tablet - Oral, Cream, Tablet, film coated, Capsule, extended release, Kit - Oral, Kit, Capsule, coated, extended release, Tablet, film coated, extended release - Oral, Capsule - Oral, Tablet, film coated - Oral, Tablet, orally disintegrating, Topical, Capsule, coated, extended release - Oral, Solution, Solution - Oral, Cream - Topical
Acute Pain
200.0 mg, 300.0 mg, 100.0 mg, , 5.8 mg/mg, 400.0 mg, 150.0 mg, 5.0 mg/mg, 50.0 mg, 5.0 mg/mL, 44.0 mg, 37.5 mg, 75.0 mg, 0.5 mg, 1.0 mg/mg, 1.0 mg/mL
Capsule, Tablet, Capsule, extended release - Oral, Oral, Tablet, extended release - Oral, Tablet, film coated, extended release, , Tablet, extended release, Tablet, coated, Tablet, delayed release - Oral, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, delayed release, Tablet - Oral, Cream, Tablet, film coated, Capsule, extended release, Kit - Oral, Kit, Capsule, coated, extended release, Tablet, film coated, extended release - Oral, Capsule - Oral, Tablet, film coated - Oral, Tablet, orally disintegrating, Topical, Capsule, coated, extended release - Oral, Solution, Solution - Oral, Cream - Topical
Premature Ejaculation
200.0 mg, 300.0 mg, 100.0 mg, , 5.8 mg/mg, 400.0 mg, 150.0 mg, 5.0 mg/mg, 50.0 mg, 5.0 mg/mL, 44.0 mg, 37.5 mg, 75.0 mg, 0.5 mg, 1.0 mg/mg, 1.0 mg/mL
Capsule, Tablet, Capsule, extended release - Oral, Oral, Tablet, extended release - Oral, Tablet, film coated, extended release, , Tablet, extended release, Tablet, coated, Tablet, delayed release - Oral, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, delayed release, Tablet - Oral, Cream, Tablet, film coated, Capsule, extended release, Kit - Oral, Kit, Capsule, coated, extended release, Tablet, film coated, extended release - Oral, Capsule - Oral, Tablet, film coated - Oral, Tablet, orally disintegrating, Topical, Capsule, coated, extended release - Oral, Solution, Solution - Oral, Cream - Topical
Warnings
Ultram has eighteen contraindications, thus it should not be ingested when confronted with any of the conditions provided in the following table.Ultram ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
convulsive disorders
Do Not Combine
Severe COPD
Do Not Combine
Intoxication
Do Not Combine
Asthma
Do Not Combine
Head
Do Not Combine
Cor Pulmonale
Do Not Combine
Status Asthmaticus
Do Not Combine
Ileus
Do Not Combine
Toxoplasma Infections
Do Not Combine
Intestinal Obstruction
Do Not Combine
Respiratory Depression
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
ethanol
Do Not Combine
Abdomen
Do Not Combine
Mental Depression
Do Not Combine
Toxoplasma Infections
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Tramadol may interact with Toxoplasma Infections
Common Ultram Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Tramadol is combined with Aclidinium.
Azelastine
Major
Tramadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Carbamazepine
Major
The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Tramadol.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Tramadol is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.
Ultram Toxicity & Overdose RiskThe lowest toxic dose of tramadol in mice is 350mg/kg. Animal studies have not been able to confirm that tramadol causes cancer in humans, but there have been reports of it causing harm to embryos and fetuses. Additionally, there is no evidence to suggest that tramadol has an effect on fertility or can cause mutations.
Ultram Novel Uses: Which Conditions Have a Clinical Trial Featuring Ultram?
18 active trials are currently being conducted to assess the efficacy of Ultram in relieving Acute Pain, Chronic Pain and Pain.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Acute Pain
21 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3
Pain
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Pain
0 Actively Recruiting
Ultram Reviews: What are patients saying about Ultram?
5Patient Review
5/15/2022 I have a lot of nerve pain and arthritis throughout my body. I've tried other treatments like injections and medication, but nothing works as well as tramadol. It's been a lifesaver for me since 2018.
5Patient Review
5/15/2022 I have a lot of nerve and arthritis pain throughout my body. I've tried injections, medication, and other treatments but nothing has worked as well as Tramadol. It stops the pain immediately for me.
5Patient Review
5/3/2022 I lifted something the wrong way and ended up with severe back pain and spasms. Tramadol worked like magic for me and completely relieved the pain.
5Patient Review
5/3/2022 I was in so much pain after I lifted something heavy and threw out my back. Spasms were constant. But as soon as I took tramadol, the pain completely disappeared. It's like magic!
4.3Patient Review
2/27/2022 I've been struggling with chronic back pain and sciatica for over two decades now. Previous treatments like Vicodin just left me feeling drowsy and unproductive at work. Tramadol really helps take the edge off so that I can still function normally despite the pain.
4.3Patient Review
8/27/2022 Tramadol has been a game changer for me in terms of managing my arthritis pain. It's made the pain much more bearable and I've been on it for six months without any decrease in efficacy, which is great. The downside is that it can cause itching and constipation, which can be bothersome, especially since I have psoriasis as well.
4.3Patient Review
9/25/2022 Tramadol has been a godsend for me. I have a degenerative joint disease, and this is the only medication that has given me more than five hours of pain relief.
4.3Patient Review
2/27/2022 I've been dealing with chronic low back pain, as well as severe sciatica off-and-on for over two decades now. Vicodin helped a little bit at first, but the dosage kept having to be increased until it became impractical and I was missing work left and right. Tramadol has been much more effective in managing my pain so that I can still lead a relatively normal life.
4.3Patient Review
8/27/2022 Tramadol has been a game changer for me in terms of managing my arthritis pain. It's made living with the condition much more bearable. The only downside is that it can cause itching and constipation, which can be exacerbated by my psoriasis.
4.3Patient Review
9/25/2022 Tramadol has been a huge help for me. It's the only medication that has provided more than five hours of pain relief, which is amazing considering I have a degenerative joint disease.
4Patient Review
12/1/2021 I've only been taking this medicine for an hour and a half, but it's already made a big difference in my lower back pain. I can move around much better now, even though the pain is still there. I'm going to stick to taking it once a day instead of three times, because I don't want to risk any side effects.
4Patient Review
12/10/2021 I'm in my early 50s and generally in good shape, though my lower back is giving me a lot of trouble lately. The pain was really bad, but after taking a 50mg tramadol, it decreased to a 3 within 45 minutes. There are some side effects (like feeling giddy) but they're not too bad. And interestingly, this medication also seems to have the side effect of increasing sexual desire!
4Patient Review
3/13/2022 I've been taking 100mg of this drug in addition to oxycodone for over 10 years. It works effectively for me and I haven't experienced any negative side effects other than the constipation caused by opioids.
4Patient Review
8/18/2022 I have arthritis and pain in most of my joints. I've had to do a partial knee replacement, as well as carpal tunnel surgery in both wrists. Pain medication doesn't completely take away the pain, but it does make it more bearable. I've been taking this for almost 15 years now, and while I do have some trouble with it (sweating due to living in Florida and the high humidity), overall it's been working well for me.
4Patient Review
5/3/2022 Tramadol was effective but I realized that I became dependent on the medication. I decided to stop taking it completely and now my main problem is insomnia. Has anyone else gone through this? How long did it take for your sleep patterns to return to normal?
4Patient Review
7/14/2022 I took this medication after having two foot surgeries and found that it was very effective in pain relief. However, the itching was unbearable at times and made me constipated and bloated. I don't think I will be taking this medication again.
4Patient Review
12/1/2021 I've only been taking this medication for an hour and a half, but it has already lessened the pain to a tolerable level. I'm a little apprehensive about taking it more than once a day as directed, but so far it seems to be helping.
4Patient Review
12/10/2021 I'm in my early 50s and generally in good shape, but my lower back is killing me. Tried this medication and it helped reduce the pain significantly within 45 minutes. There are some side effects (e.g., feeling giddy, increased sex drive) that come with it, but they're not too bad overall.
4Patient Review
7/14/2022 I took this medication after having two foot surgeries and found that while it did help with the pain, the itching was unbearable. I also experienced constipation and bloating, which were unfortunately not worth the relief from pain.
4Patient Review
5/3/2022 I found Tramadol to be effective for my restless leg syndrome. However, I realized that I was becoming dependent on the medication and made the decision to go cold turkey. Now, I'm having trouble sleeping. Does anyone have any advice on how long it will take for my sleep pattern to return to normal? In the meantime, I've found supplements and lidocaine patches helpful.
4Patient Review
3/13/2022 I've been taking 100mg of this treatment in addition to oxycodone for over 10 years. It works great for me--better than anything else I've tried. And I've had two spinal surgeries and a failed fusion.
4Patient Review
8/18/2022 I've been living with arthritis pain for a long time, and this medication has really helped make it manageable. I only have to take two pills a day, but even then I still sometimes have trouble. This year the humidity has been particularly bad, and that makes it harder to deal with the pain.
2.7Patient Review
3/9/2022 I'm disappointed because this treatment didn't work for me. I have chronic nerve pain from a herniated disc, and this medication did nothing to help ease the discomfort.
2.7Patient Review
3/9/2022 I was really hoping this would help with my herniated disc, but unfortunately I didn't notice any change in my chronic nerve pain.
1.7Patient Review
9/21/2022 This drug was not at all effective for me. It was a complete waste of time and money.
1.7Patient Review
9/21/2022 This drug was completely ineffective for me. It was a waste of money and time.
1.3Patient Review
1/23/2022 Tramadol has a lot of side effects that often outweigh the benefits. If you're taking it for pain, be aware that it may not actually relieve much discomfort. Additionally, common side effects include moodiness, depression, loss of appetite and nausea.
1.3Patient Review
1/23/2022 Tramadol has a lot of side effects and does very little to actually relieve pain. Side effects I experienced included moodiness, depression, loss of appetite and nausea.
Patient Q&A Section about ultram
What is the medicine Ultram used for?
"This medication is used to relieve moderate to moderately severe pain using Tramadol, an opioid analgesic. The drug works by changing how pain is felt and responded to in the brain." - Anonymous Online Contributor
Unverified Answer
Why is Ultram an opioid?
"The medication ULTRAM contains the active ingredient tramadol, which is a type of drug that activates certain opioid receptors in the brain while also inhibiting the re-uptake of serotonin and norepinephrine. While the exact way that this drug works is not fully understood, it is believed that the pain-relieving effects of tramadol are due to both the activation of the µ-opioid receptors and the weak inhibition of serotonin and norepinephrine." - Anonymous Online Contributor
Unverified Answer
Which is stronger oxycodone or Ultram?
"Tramadol may be less likely to cause addiction and dependence than oxycodone, but it is not as effective at relieving pain. Tramadol can cause mood-boosting properties and respiratory depression, but it also carries the risk of seizure." - Anonymous Online Contributor
Unverified Answer
Is Ultram a strong medication?
"Tramadol (Ultram) is a potent painkiller that is used to relieve moderate to severe pain. It is typically used when non-opioid painkillers are no longer effective at controlling the pain." - Anonymous Online Contributor
Unverified Answer