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What is Ubrelvy
UbrogepantThe Generic name of this drug
Treatment SummaryUbrogepant is a medication used to treat migraine headaches in adults. It was approved by the FDA in December 2019 and is the first oral drug of its kind to be used for the acute treatment of migraines. Compared to current treatments like triptans, ubrogepant is better tolerated, does not cause medication overuse headaches, and has no cardiovascular risk, making it suitable for patients with cardiovascular disease. This drug may become the new standard of therapy for the treatment of migraine headaches.
Ubrelvyis the brand name
Ubrelvy Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ubrelvy
Ubrogepant
2019
2
Effectiveness
How Ubrelvy Affects PatientsUbrogepant relieves migraine headache pain by preventing a certain chemical from being active. People with severe liver or kidney problems may need to take a lower dose of ubrogepant and it is not recommended for those with end-stage kidney disease.
How Ubrelvy works in the bodyUbrogepant is a drug used to treat migraine headaches. It works by blocking the action of calcitonin gene-related peptide (CGRP), a molecule that helps the body create pain signals. CGRP is released during migraine attacks and binds to receptors in the trigeminal ganglion, a network of nerves that send pain signals to the brain. By blocking the action of CGRP, Ubrogepant stops the body from amplifying and perpetuating the migraine headache pain, ultimately stopping the headache.
When to interrupt dosage
The prescribed amount of Ubrelvy is contingent upon the diagnosed condition. The exact dosage depends on the mode of delivery, noted in the following table.Condition
Dosage
Administration
Migraine Without Aura
50.0 mg, , 100.0 mg
, Tablet - Oral, Tablet, Oral
Migraine With Aura
50.0 mg, , 100.0 mg
, Tablet - Oral, Tablet, Oral
Warnings
Ubrelvy ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Ubrelvy Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Moderate
The serum concentration of Axitinib can be increased when it is combined with Ubrogepant.
Belantamab mafodotin
Moderate
The serum concentration of Belantamab mafodotin can be increased when it is combined with Ubrogepant.
Bendamustine
Moderate
The serum concentration of Bendamustine can be increased when it is combined with Ubrogepant.
Binimetinib
Moderate
The serum concentration of Binimetinib can be increased when it is combined with Ubrogepant.
Bortezomib
Moderate
The serum concentration of Bortezomib can be increased when it is combined with Ubrogepant.
Ubrelvy Toxicity & Overdose RiskNot much is known about the toxicity of ubrogepant, so it is recommended that those who overdose be monitored for at least 24 hours, since the drug has a half-life of 5 to 7 hours.
Ubrelvy Novel Uses: Which Conditions Have a Clinical Trial Featuring Ubrelvy?
4 active trials are currently underway to investigate the potential of Ubrelvy in addressing Migraine Without Aura.Condition
Clinical Trials
Trial Phases
Migraine With Aura
3 Actively Recruiting
Not Applicable
Migraine Without Aura
2 Actively Recruiting
Not Applicable
Ubrelvy Reviews: What are patients saying about Ubrelvy?
5Patient Review
1/11/2021 I was worried that this medication would make me nauseous, but it didn't. Not only that, but it worked quickly and completely got rid of my migraine. I've been suffering from chronic migraines for 30 years and have tried all kinds of medications with poor results. The first time I tried Ubrelvy I was already on day 2 of my migraine and it still worked!
5Patient Review
8/9/2020 Even though it takes a little bit for this medication to work, it's really amazing. In most cases, my migraines were completely gone within two hours.
5Patient Review
11/18/2020 I am thoroughly impressed with this medication. I've been struggling with migraines and vertigo for over 20 years, and this is the first time I've found something that can actually stop a vertigo attack in its tracks.
5Patient Review
6/4/2021 This medication completely alleviated all of my chronic pain, including migraines and neck/eye pain. No side effects that I could tell, other than the fact that it's quite expensive.
5Patient Review
11/18/2021 This medication works incredibly fast, within two hours for the majority of my headaches. The only downside is a very slight drowsiness; however, it is well worth it for the relief it provides. Additionally, coupons make this drug very affordable.
5Patient Review
1/26/2022 This drug is really a lifesaver. It quickly and effectively gets rid of my headaches with no negative side effects. I've recommended it to other people who also suffer from migraines, and they've all had great results as well.
5Patient Review
5/17/2022 Ubrelvy has given me my life back. I had migraines for 30 years and tried everything with no avail--until this medication. It's a near miracle how well it works; almost every time, with very few side effects (just a bit of drowsiness). If only insurance would cover more than 9 per month!
5Patient Review
7/1/2022 This medication is extremely effective for me in treating migraines. I don't experience any negative side effects, which is wonderful. Additionally, I appreciate that it comes in single-use packaging--it's easy to keep on hand wherever I might need it.
3.3Patient Review
9/8/2020 I've had migraines for 25 years and have tried all the Triptans. Maxalt was loosing its effectiveness so MD gave me Ubrevly to try. I can't say it doesn't work, it does. BUT I get awful nausea from it and debilitating fatigue. Even after the nausea subsides, I'm still too tired to function during the day. This is my experience, the drug works well, after 1 hr or so. So I recommend trying it if you have insurance to cover the cost.
2.3Patient Review
3/19/2022 I was really hopeful for this medication, as my other options are limited due to high blood pressure. Unfortunately, it didn't work at all for me.
2.3Patient Review
9/14/2022 I had high hopes for this new migraine medication, but unfortunately it did not work for me. I got very hot, flushed, and nauseous about an hour after taking it, and my migraines were actually worse.
2.3Patient Review
11/7/2022 I've been diagnosed with vestibular migraines for three years now, and I've tried this medication a few times. Unfortunately, it has made my migraines worse on five out of seven occasions. It gives me a piercing headache and makes my head feel tight. I also usually start feeling nauseous.
1Patient Review
12/20/2020 I tried this medication for migraines, but not only did it not help at all, it also caused me stomach pain.
Patient Q&A Section about ubrelvy
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is UBRELVY prescribed for?
"Ubrogepant is a medication used to treat migraines which may work by changing the amount of a certain natural substance in the brain. It is effective in relieving headaches, pain, and other symptoms associated with migraines such as nausea, vomiting, and sensitivity to light and sound."
Answered by AI
What are side effects of UBRELVY?
"You may experience heart problems, such as changes in blood pressure, numbness or tingling in your extremities, or difficulty sleeping."
Answered by AI
Is UBRELVY only for migraines?
"Ubrelvy is a medication used to treat migraine symptoms in adults. It is not meant to be used in children, and it cannot prevent migraine symptoms. Symptoms of migraine include severe headaches, nausea, vomiting, and visual or sensory changes called an aura."
Answered by AI
Is UBRELVY a narcotic?
"Ubrelvy is non-narcotic, not scheduled, and does not have addiction potential. It is available in two doses (50 mg and 100 mg) and is designed to allow healthcare providers to tailor treatment to the needs of individual patients."
Answered by AI