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What is Tykerb
LapatinibThe Generic name of this drug
Treatment SummaryLapatinib is a cancer drug developed by GlaxoSmithKline to treat certain types of solid tumors like breast and lung cancer. It was approved by the FDA in 2007 and is used in combination with the chemotherapy drug Capecitabine. Lapatinib works by blocking the activity of two proteins, HER2/ERBB2 and HER1/EGFR/ERBB1, which are responsible for tumor growth. It binds to these proteins and prevents them from initiating the growth of cancer cells.
Tykerbis the brand name
Tykerb Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tykerb
Lapatinib
2007
3
Approved as Treatment by the FDA
Lapatinib, also called Tykerb, is approved by the FDA for 4 uses which include Postmenopause and Metastatic Breast Cancer .Postmenopause
Used to treat Postmenopausal in combination with Letrozole
Metastatic Breast Cancer
Used to treat Metastatic Breast Cancer in combination with Letrozole
Advance Directives
Used to treat refractory, advanced Breast cancer in combination with Capecitabine
Breast
Used to treat refractory, metastatic Breast cancer in combination with Capecitabine
Effectiveness
How Tykerb Affects PatientsLapatinib is a medicine developed by GlaxoSmithKline to treat certain types of cancer, like breast and lung cancer. It works by blocking certain proteins in the body that can cause tumour growth. The US Food and Drug Administration (FDA) approved lapatinib for use in patients with advanced cancer in March 2007, and it is usually taken in combination with another chemotherapy drug called capecitabine.
How Tykerb works in the bodyLapatinib is a drug that stops the growth of cancer cells by blocking two proteins, HER1/EGFR/ERBB1 and HER2/ERBB2. When used with a drug called 5-Flurouracil, its effects are even greater. Lapatinib has been shown to keep cancer cells from growing in the presence of another cancer-fighting drug, trastuzumab. This suggests that lapatinib and trastuzumab work differently and can be used together.
When to interrupt dosage
The prescribed measure of Tykerb is contingent upon the diagnosed ailment, including Advance Directives, Postmenopause and Metastatic Breast Cancer. The magnitude of dosage is contingent upon the technique of delivery (e.g. Tablet - Oral or Oral) outlined in the table beneath.Condition
Dosage
Administration
Advance Directives
, 250.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Metastatic Breast Cancer
, 250.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Breast
, 250.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Postmenopause
, 250.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Tykerb.Common Tykerb Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Lapatinib.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Lapatinib.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Lapatinib.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Lapatinib.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Lapatinib.
Tykerb Toxicity & Overdose RiskA patient who took an excessive amount of lapatinib (3,000 mg) experienced severe diarrhea and vomiting after 10 days of taking the drug.
Tykerb Novel Uses: Which Conditions Have a Clinical Trial Featuring Tykerb?
78 active trials are being conducted to assess the potential of Tykerb in managing Advance Directives, Metastatic Breast Cancer and Breast Diseases.Condition
Clinical Trials
Trial Phases
Breast
0 Actively Recruiting
Metastatic Breast Cancer
95 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1
Advance Directives
0 Actively Recruiting
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Tykerb Reviews: What are patients saying about Tykerb?
5Patient Review
7/15/2011 I've been taking this medication for an entire year now with no negative symptoms. In fact, most of my cancer has decreased in size or disappeared altogether. The only remaining growth is in one area of my brain, but I'm hopeful that cyberknife will help with that too.
5Patient Review
7/11/2008 My mother takes Tykerb as prescribed by her doctor, but she's been experiencing terrible itching spells that no cream or medication can seem to get rid of. I've been having her take Benadryl every four hours, but it makes her drowsy and unable to do much around the house.
5Patient Review
4/11/2009 This treatment was successful for me and easy to use.
4.3Patient Review
1/10/2013 After my Herceptin treatments started to wear off, my doctor prescribed Tykerb in addition. I take four pills a day and have been for three months now. The side effects are manageable; some diarrhea but Imodium works well to stop it. I also take Phillips Colon Health Probiotic which really helped me with the chemo-induced diarrhea. So far so good according to my doctor's checkups every three weeks.
4Patient Review
9/21/2007 So far, so good. The last CT scan showed that the lung lesions were shrinking. I have developed some skin nodules on my breast, but nothing too severe. Just some fatigue, hand/foot tingling, and some digestive symptoms which might be due the Xeloda (I don't know for sure).
3.7Patient Review
4/8/2009 Itchy skin, acne, and diarrhea are all pretty common side effects of this treatment, but it's been keeping my tumors stable so I'm sticking with it for now.
3.7Patient Review
7/24/2012 I've been on Tykerb for two months and have had to deal with fairly severe diarrhea since. Sometimes Imodium will help, but not always. I'm also worried about developing acne as a side effect, but so far haven't experienced this. There is some stomach pain from time to time, but thankfully it's nothing too intense or unbearable...yet.
3.3Patient Review
11/27/2017 I've been on this treatment for nine weeks, in conjunction with taxol. I have a PET scan tomorrow that will give more information.
1Patient Review
3/13/2016 I tried this treatment while already on Herceptin, Xeloda, and Letrozole, but it just made me feel worse. I experienced dizziness, increased fatigue, anxiety, and depression. I could also feel my hair follicles burning before I started losing my hair.
Patient Q&A Section about tykerb
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Tykerb used to treat?
"Lapatinib is used to treat a certain type of breast cancer that is positive for the HER2 protein. It works by slowing or stopping the growth of cancer cells."
Answered by AI
Does Tykerb cause hair loss?
"Capecitabine and lapatinib, two oral drugs used to treat breast cancer, may cause hair thinning instead of the toxic alopecia (hair loss) that can be caused by intravenous chemotherapeutic agents."
Answered by AI
Is Tykerb chemotherapy?
"Tykerb is a targeted chemotherapy drug that is taken with another drug to treat breast cancer. The drugs that it is taken with are Xeloda (capecitabine) or Femara (letrozole)."
Answered by AI