Tykerb

Breast, Advance Directives, Postmenopause + 1 more

Treatment

6 FDA approvals

9 Active Studies for Tykerb

Treatment for

Breast

What is Tykerb

LapatinibThe Generic name of this drug

Treatment SummaryLapatinib is a cancer drug developed by GlaxoSmithKline to treat certain types of solid tumors like breast and lung cancer. It was approved by the FDA in 2007 and is used in combination with the chemotherapy drug Capecitabine. Lapatinib works by blocking the activity of two proteins, HER2/ERBB2 and HER1/EGFR/ERBB1, which are responsible for tumor growth. It binds to these proteins and prevents them from initiating the growth of cancer cells.

Tykerbis the brand name

image of different drug pills on a surface

Tykerb Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tykerb

Lapatinib

2007

Approved as Treatment by the FDA

Lapatinib, also called Tykerb, is approved by the FDA for 6 uses which include refractory, metastatic Breast cancer and Metastatic Breast Cancer .

refractory, metastatic Breast cancer

Used to treat refractory, metastatic Breast cancer in combination with Capecitabine

Metastatic Breast Cancer

Used to treat Metastatic Breast Cancer in combination with Letrozole

Breast

Used to treat refractory, metastatic Breast cancer in combination with Capecitabine

Postmenopause

Used to treat Postmenopausal in combination with Letrozole

Advance Directives

Used to treat refractory, advanced Breast cancer in combination with Capecitabine

Metastatic Breast Cancer

Used to treat Metastatic Breast Cancer in combination with Letrozole

Effectiveness

How Tykerb Affects PatientsLapatinib is a medicine developed by GlaxoSmithKline to treat certain types of cancer, like breast and lung cancer. It works by blocking certain proteins in the body that can cause tumour growth. The US Food and Drug Administration (FDA) approved lapatinib for use in patients with advanced cancer in March 2007, and it is usually taken in combination with another chemotherapy drug called capecitabine.

How Tykerb works in the bodyLapatinib is a drug that stops the growth of cancer cells by blocking two proteins, HER1/EGFR/ERBB1 and HER2/ERBB2. When used with a drug called 5-Flurouracil, its effects are even greater. Lapatinib has been shown to keep cancer cells from growing in the presence of another cancer-fighting drug, trastuzumab. This suggests that lapatinib and trastuzumab work differently and can be used together.

When to interrupt dosage

The prescribed measure of Tykerb is contingent upon the diagnosed ailment, including Advance Directives, Postmenopause and Metastatic Breast Cancer. The magnitude of dosage is contingent upon the technique of delivery (e.g. Tablet - Oral or Oral) outlined in the table beneath.

Condition

Dosage

Administration

Breast

, 250.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Advance Directives

, 250.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Postmenopause

, 250.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Metastatic Breast Cancer

, 250.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Tykerb.

Common Tykerb Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Lapatinib.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Lapatinib.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Lapatinib.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Lapatinib.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Lapatinib.

Tykerb Toxicity & Overdose RiskA patient who took an excessive amount of lapatinib (3,000 mg) experienced severe diarrhea and vomiting after 10 days of taking the drug.

image of a doctor in a lab doing drug, clinical research

Tykerb Novel Uses: Which Conditions Have a Clinical Trial Featuring Tykerb?

78 active trials are being conducted to assess the potential of Tykerb in managing Advance Directives, Metastatic Breast Cancer and Breast Diseases.

Condition

Clinical Trials

Trial Phases

Postmenopause

8 Actively Recruiting

Phase 2, Not Applicable, Phase 1

Breast

0 Actively Recruiting

Advance Directives

0 Actively Recruiting

Metastatic Breast Cancer

1 Actively Recruiting

Phase 1, Phase 2

Tykerb Reviews: What are patients saying about Tykerb?

5Patient Review

7/15/2011

Tykerb for Breast Cancer that has Spread to Another Part of the Body

I've been taking this medication for an entire year now with no negative symptoms. In fact, most of my cancer has decreased in size or disappeared altogether. The only remaining growth is in one area of my brain, but I'm hopeful that cyberknife will help with that too.

5Patient Review

7/11/2008

Tykerb for HER2 Positive Breast Cancer

My mother takes Tykerb as prescribed by her doctor, but she's been experiencing terrible itching spells that no cream or medication can seem to get rid of. I've been having her take Benadryl every four hours, but it makes her drowsy and unable to do much around the house.

5Patient Review

4/11/2009

Tykerb for HER2 Positive Breast Cancer

This treatment was successful for me and easy to use.

4.3Patient Review

1/10/2013

Tykerb for HER2 Positive Breast Cancer

After my Herceptin treatments started to wear off, my doctor prescribed Tykerb in addition. I take four pills a day and have been for three months now. The side effects are manageable; some diarrhea but Imodium works well to stop it. I also take Phillips Colon Health Probiotic which really helped me with the chemo-induced diarrhea. So far so good according to my doctor's checkups every three weeks.

4Patient Review

9/21/2007

Tykerb for Breast Cancer that has Spread to Another Part of the Body

So far, so good. The last CT scan showed that the lung lesions were shrinking. I have developed some skin nodules on my breast, but nothing too severe. Just some fatigue, hand/foot tingling, and some digestive symptoms which might be due the Xeloda (I don't know for sure).

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tykerb

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you take Tykerb?

"Tykerb can be taken indefinitely as part of a regimen including the chemotherapy medication Xeloda or the hormonal therapy medicine Femara, both of which are pills taken orally. This approach helps to keep the cancer under control."

Answered by AI

When should I take Tykerb?

"The recommended dose of TYKERB is 5 tablets taken all at once, at least one hour before or one hour after a meal, once a day. Dividing the daily dose is not recommended. Capecitabine should be taken with food or within 30 minutes after food."

Answered by AI

What is Tykerb used to treat?

"Lapatinib is used to treat a certain type of breast cancer that is positive for the HER2 protein. It works by slowing or stopping the growth of cancer cells."

Answered by AI

Does Tykerb cause hair loss?

"Capecitabine and lapatinib, two oral drugs used to treat breast cancer, may cause hair thinning instead of the toxic alopecia (hair loss) that can be caused by intravenous chemotherapeutic agents."

Answered by AI

Is Tykerb chemotherapy?

"Tykerb is a targeted chemotherapy drug that is taken with another drug to treat breast cancer. The drugs that it is taken with are Xeloda (capecitabine) or Femara (letrozole)."

Answered by AI