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What is Twirla
EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol, developed in 1938, is a form of the hormone estrogen that is able to be taken orally. Its approval by the FDA in 1943 allowed it to be used in contraceptive pills, replacing an earlier form of estrogen called mestranol. Ethinylestradiol is still widely used in contraception today.
LOESTRIN Fe 1.5/30is the brand name
Twirla Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679
Approved as Treatment by the FDA
Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .Birth Control
Used to treat Contraception in combination with Levonorgestrel
Effectiveness
How Twirla Affects PatientsEthinylestradiol is a synthetic form of the hormone estrogen. It prevents ovulation by decreasing luteinizing hormone and gonadotrophic hormone. It is usually taken once daily and is generally considered to be very safe, though patients should be aware of potential risks of thrombotic events.
How Twirla works in the bodyEthinylestradiol is a synthetic estrogen used in oral contraceptives. It works by stopping ovulation, blocking the travel of sperm, and preventing fertilized eggs from attaching to the uterus. It also reduces luteinizing hormone, decreasing the ability of the uterus to accept a fertilized egg. It also increases a protein in the body that binds to hormones, reducing their effect.
When to interrupt dosage
The proposed dosage of Twirla is based on the identified problem, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The amount of dosage is contingent upon the method of delivery, as outlined in the table below.Condition
Dosage
Administration
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Warnings
Twirla has twenty-six contraindications, so it should not be administered in concurrence with any of the ailments indicated in the following table.Twirla ContraindicationsCondition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
Common Twirla Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Twirla Toxicity & Overdose RiskWomen who overdose on this drug may experience abnormal vaginal bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment should focus on providing supportive care and monitoring potassium, sodium, and signs of metabolic acidosis.
Twirla Novel Uses: Which Conditions Have a Clinical Trial Featuring Twirla?
38 active clinical trials are assessing the potential of Twirla to provide Folate supplementation therapy, ameliorate Premenstrual Dysphoric Disorder and alleviate Menopause symptoms.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Twirla Reviews: What are patients saying about Twirla?
5Patient Review
3/26/2021 I really like this new patch from Agile Therapeutics. It's called Twirla and it's much safer than my other patch. A few of my girlfriends have switched from the pill as well because they always forget to take it. Safe, effective, donâ??t have to worry about taking a pill everyday.
5Patient Review
6/21/2021 This patch is excellent for helping with cramps. It's also helped clear my acne and made my mood swings disappear. Plus, it doesn't cause weight gain like some other treatments can.
5Patient Review
6/21/2021 Switched from Xulane to Zafemy to Twirla and Twirla is the best by a landslide. Sticks great and you dont even feel it. Best on the market if you are like me and hate having to take a pill everyday.
5Patient Review
7/21/2021 I was looking for a way to avoid taking the pill, which was messing with my hormones. My doctor recommended Twirla, and I'm really glad I tried it. It's been keeping me much more balanced.
5Patient Review
8/16/2022 This is the best birth control I've used in my five months of using it.
5Patient Review
6/7/2021 This is such an easy method that I'll never go back to taking pills again.
5Patient Review
3/7/2022 I switched from Xulane to Twirla because it has a lower estrogen dose and I'm glad I did. The lower estrogen dose means less side effects and it's also easier to remove when it's time to take off.
5Patient Review
2/24/20215Patient Review
7/9/2021 This IUD is a huge improvement over the pill. No more cramps or mood swings for me!
5Patient Review
7/9/2021 This treatment is easy to use and works great.
4.7Patient Review
6/1/2021 I really enjoy using Twirla. It's been working great for me and it's so much easier to use than other methods like pills or more invasive treatments.
4.7Patient Review
10/29/2022 I was recommended Twirla by a friend and I'm really glad I tried it. It works great and I prefer it to the pill.
3.3Patient Review
6/6/2022 At first, this treatment worked great for me. My periods were really bad before, but then they stopped coming altogether for a month. When I started getting them again, they were longer than before-- lasting 9 days instead of 4.
2.3Patient Review
10/4/2022 I failed to use this medication correctly and as a result got pregnant. I want to be clear that it wasn't the medication's fault, but rather my own irresponsible usage. Please be careful if you decide to use this treatment.
1.3Patient Review
10/4/2022 I have never left a review before, but I feel compelled to warn others about this product. Within two hours of using it, I felt incredibly sick and experienced wild mood swings. I don't know what was in it, but whatever hormones it released were totally out of whack.
1Patient Review
10/4/2022 I would not recommend this product to anyone. I felt an intense burning and stinging sensation less than 30 minutes after inserting it, and had to struggle to remove it due to the strength of the adhesive.
Patient Q&A Section about twirla
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How fast does Twirla work?
"If you start using Twirla within the first 24 hours of your period, you will not need to use any other form of contraception for the first 7 days. If you start using Twirla after the first 24 hours of your period, you will need to use a non-hormonal form of contraception, such as condoms or spermicide, for the first 7 days."
Answered by AI
Does Twirla patch make you gain weight?
"The most common side effects of using the Twirla patch are skin reactions at the application site and weight gain. Other possible side effects include menstrual cramps."
Answered by AI
How effective is the Twirla patch?
"The SECURE Trail found that Twirla was 95% effective in preventing pregnancy, which is the same as other combined hormonal contraceptives."
Answered by AI
Is Twirla better than Xulane?
"The findings of a study showed that Twirla was more effective in contraceiving women with a lower body mass index (BMI). The pregnancy rate per 100 woman-years of Xulane use was 1.07 (95% CI 0.6-, 1.76). Xulane is said to be less effective in women with a higher BMI. In a year-long phase 3 trial, 5% of all the Twirla patches (55,900) worn fully detached."
Answered by AI