Trizivir

HIV Transmission, HIV, Antiretroviral Treatment + 1 more

Treatment

1 FDA approval

20 Active Studies for Trizivir

Treatment for

HIV Transmission

What is Trizivir

ZidovudineThe Generic name of this drug

Treatment SummaryAZT is a medication used to treat HIV and AIDS. It works by preventing the formation of chemical bonds that are needed to complete the virus’s genetic material. AZT is effective in decreasing viral replication and improving immune system function, but it can also cause bone marrow suppression and other side effects.

Retroviris the brand name

image of different drug pills on a surface

Trizivir Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Retrovir

Zidovudine

1987

Approved as Treatment by the FDA

Zidovudine, commonly known as Retrovir, is approved by the FDA for 1 uses which include HIV .

HIV

Used to treat Human Immunodeficiency Virus (HIV) Infections in combination with Abacavir

Effectiveness

How Trizivir Affects PatientsZidovudine is a drug that fights HIV-1 by interfering with the virus’s ability to replicate. It changes the structure of a building block of the virus’s DNA, making it unable to continue growing. This blocks the virus from multiplying and reduces its presence in the body.

How Trizivir works in the bodyZidovudine works by stopping HIV from reproducing. It does this by mimicking a natural molecule, thymidine, and then binding to the HIV's reverse transcriptase. This prevents the virus from completing its DNA chain and reproducing. Zidovudine also weakly blocks the DNA polymerase enzymes that help reproduce cellular DNA.

When to interrupt dosage

The prescribed measure of Trizivir is contingent upon the diagnosed condition, including perinatal HIV transmission, HIV Transmission and HIV. The dosage amount is also contingent upon the method of delivery (e.g. Injection, solution - Intravenous or Oral) presented in the following table.

Condition

Dosage

Administration

HIV

, 300.0 mg, 10.0 mg/mL, 50.0 mg/mL, 100.0 mg

Injection, solution - Intravenous, Oral, Tablet - Oral, Injection, solution, Liquid - Intravenous, Tablet, Syrup - Oral, , Liquid, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Solution - Oral, Tablet, coated, Solution, Solution - Intravenous, Capsule - Oral, Intravenous, Syrup

HIV Transmission

, 300.0 mg, 10.0 mg/mL, 50.0 mg/mL, 100.0 mg

perinatal HIV transmission

, 300.0 mg, 10.0 mg/mL, 50.0 mg/mL, 100.0 mg

Antiretroviral Treatment

, 300.0 mg, 10.0 mg/mL, 50.0 mg/mL, 100.0 mg

Warnings

There are 20 known major drug interactions with Trizivir.

Common Trizivir Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Zidovudine is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Zidovudine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abetimus

Major

The risk or severity of adverse effects can be increased when Zidovudine is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Zidovudine is combined with Acteoside.

Aldosterone

Major

The risk or severity of adverse effects can be increased when Zidovudine is combined with Aldosterone.

Trizivir Toxicity & Overdose RiskOverdosing on this drug can lead to symptoms such as fatigue, headache, nausea, and vomiting. The lowest toxic dose for this drug in mice is 3084mg/kg if taken orally.

Trizivir Novel Uses: Which Conditions Have a Clinical Trial Featuring Trizivir?

122 active clinical trials are currently assessing the potential of Trizivir to reduce the risk of HIV Transmission, perinatal HIV transmission, and HIV infection.

Condition

Clinical Trials

Trial Phases

HIV Transmission

0 Actively Recruiting

perinatal HIV transmission

0 Actively Recruiting

HIV

133 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Antiretroviral Treatment

1 Actively Recruiting

Phase 2

Trizivir Reviews: What are patients saying about Trizivir?

5Patient Review

10/12/2007

Trizivir for HIV

Trizivir has been a godsend for me. After early intervention of my HIV infection, I have remained quite healthy. My T-Cells range between 400 and 850, and my viral load remains undetectable.

5Patient Review

4/23/2010

Trizivir for HIV

I've been taking this medication for a while and it's worked well for me, but my doctor is changing me to Atripla. I'm scared to change because I've been taking this a long time. I am hoping the benefits are better. This medication can cause heart disease my doctor told me, so I am changing. My first dose on Atripla was last night and felt a little weird this morning but I feel better this afternoon..

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about trizivir

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is abacavir used for?

"Abacavir is used in conjunction with other medications to treat human immunodeficiency virus (HIV) infection. Abacavir is part of a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It functions by decreasing the amount of HIV in the blood."

Answered by AI

What is Trizivir used for?

"This medication is used to treat adults who are infected with human immunodeficiency virus (HIV), the virus that causes acquired immune deficiency syndrome (AIDS). It is used to replace treatment with the three active substances (abacavir, lamivudine and zidovudine) taken separately at doses similar to those in Trizivir."

Answered by AI

Can abacavir be taken alone?

"This combination of drugs is used to treat HIV infection, either on its own or with other medications."

Answered by AI

When is Triumeq generic?

"Generic versions of Triumeq may not be available until December 8, 2029, due to patent and regulatory protections."

Answered by AI

Clinical Trials for Trizivir

Image of Rhode Island Hospital in Providence, United States.

Preliminary Test Of Combined LAI Treatmentfor HIV/AIDS

18+

All Sexes

Providence, RI

This trial will explore how new long-acting HIV and opioid addiction medications may be used, and how to promote their uptake. Qualitative interviews will be conducted with stakeholders to understand attitudes, barriers, and facilitators.

Phase < 1

Recruiting

Has No Placebo

Rhode Island HospitalKirsten K Langdon, Ph.D.

Image of Icahn School of Medicine at Mount Sinai in New York, United States.

Persuasive Health Communication Intervention Delivered By Health Educatorfor HIV/AIDS

18+

All Sexes

New York, NY

This trial will assess how a brief persuasive health communication intervention can increase HIV/HCV screening acceptance among ED patients who initially declined. It will compare two delivery forms of this intervention, by a video or HIV/HCV counselor, and assess its efficacy among different injection-drug use history cohorts.

Waitlist Available

Has No Placebo

Icahn School of Medicine at Mount SinaiRoland C Merchant, MD

Image of University of Alabama at Birmingham in Birmingham, United States.

High-Intensity Interval Trainingfor HIV/AIDS

18+

All Sexes

Birmingham, AL

This trial will study if exercise can help people 50+ living with HIV who have suboptimal cognition. 60 participants in Alabama will be monitored over 3 months to measure the effects of exercise.

Waitlist Available

Has No Placebo

University of Alabama at BirminghamRaymond Jones, Ph.D.

Image of Washington University in St. Louis in Saint Louis, United States.

Suubi-Mhealthfor Depression

14 - 17

All Sexes

Saint Louis, MO

This trial will create a digital therapy tool to help Ugandan teens with HIV and depression, using CBT to improve mental health and ART adherence.

Recruiting

Has No Placebo

Washington University in St. Louis

Have you considered Trizivir clinical trials? We made a collection of clinical trials featuring Trizivir, we think they might fit your search criteria.

Image of Albert Einstein College of Medicine in Bronx, United States.

Have you considered Trizivir clinical trials? We made a collection of clinical trials featuring Trizivir, we think they might fit your search criteria.

Image of Atrium Health Wake Forest Baptist in Winston-Salem, United States.

Activity Interventionfor HIV/AIDS

18+

All Sexes

Winston-Salem, NC

This trial looks at how HIV affects frailty and pre-frailty in people over 50. It's being done at Atrium Health's IDSC clinic.

Recruiting

Has No Placebo

Atrium Health Wake Forest BaptistCaryn G Morse, MD, MPH

Image of UW Positve Research, Harborview Medical Center in Seattle, United States.

TLC-ART 101 Dosage 2Afor HIV/AIDS

18 - 65

All Sexes

Seattle, WA

This trial tests a new HIV treatment platform to determine if it can be used with other drugs. Healthy adults without HIV will participate in the 57-day study at UW Positive Research. There will be 12-16 participants.

Phase 1

Recruiting

Has No Placebo

UW Positve Research, Harborview Medical CenterRachel A Bender Ignacio, MD MPH

Image of Grady Memorial Hospital in Atlanta, United States.

Baricitinibfor HIV/AIDS

18 - 65

All Sexes

Atlanta, GA

This trial will test if inflammation can cause depression in HIV patients. 60 HIV+ depressed patients will get drug or placebo for 10 wks. They'll do tests, scans, & optional spinal taps over 5 months.

Phase 2

Waitlist Available

2 Prior Treatments

Grady Memorial Hospital (+1 Sites)Andrew H Miller, MD

Image of Massachusetts General Hospital Cancer Center in Boston, United States.

Varenicline + Positively Smoke Free - Mobilefor HIV/AIDS

18+

All Sexes

Boston, MA

This trial will test if an intervention combining a mobile program and medication can help people with HIV quit smoking.

Phase 3

Waitlist Available

Has No Placebo

Massachusetts General Hospital Cancer CenterGina Kruse, MD

Have you considered Trizivir clinical trials? We made a collection of clinical trials featuring Trizivir, we think they might fit your search criteria.