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What is Trizivir
LamivudineThe Generic name of this drug
Treatment SummaryAZT is a medication used to treat HIV and AIDS. It works by preventing the formation of chemical bonds that are needed to complete the virus’s genetic material. AZT is effective in decreasing viral replication and improving immune system function, but it can also cause bone marrow suppression and other side effects.
Epiviris the brand name
Trizivir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Epivir
Lamivudine
1995
178
Approved as Treatment by the FDA
Lamivudine, otherwise called Epivir, is approved by the FDA for 3 uses which include Chronic Hepatitis B Infection and HIV .Chronic Hepatitis B Infection
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Abacavir
HIV
Effectiveness
How Trizivir Affects PatientsZidovudine is a drug that fights HIV-1 by interfering with the virus’s ability to replicate. It changes the structure of a building block of the virus’s DNA, making it unable to continue growing. This blocks the virus from multiplying and reduces its presence in the body.
How Trizivir works in the bodyZidovudine works by stopping HIV from reproducing. It does this by mimicking a natural molecule, thymidine, and then binding to the HIV's reverse transcriptase. This prevents the virus from completing its DNA chain and reproducing. Zidovudine also weakly blocks the DNA polymerase enzymes that help reproduce cellular DNA.
When to interrupt dosage
The prescribed measure of Trizivir is contingent upon the diagnosed condition, including perinatal HIV transmission, HIV Transmission and HIV. The dosage amount is also contingent upon the method of delivery (e.g. Injection, solution - Intravenous or Oral) presented in the following table.Condition
Dosage
Administration
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Hepatitis B Infection
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Anti-Retroviral Agents
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
treatment failure
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
There are 20 known major drug interactions with Trizivir.Common Trizivir Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Lamivudine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Lamivudine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Lamivudine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Lamivudine may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Minor
Lamivudine may decrease the excretion rate of Almasilate which could result in a higher serum level.
Trizivir Toxicity & Overdose RiskOverdosing on this drug can lead to symptoms such as fatigue, headache, nausea, and vomiting. The lowest toxic dose for this drug in mice is 3084mg/kg if taken orally.
Trizivir Novel Uses: Which Conditions Have a Clinical Trial Featuring Trizivir?
122 active clinical trials are currently assessing the potential of Trizivir to reduce the risk of HIV Transmission, perinatal HIV transmission, and HIV infection.Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Treatment Naive
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Trizivir Reviews: What are patients saying about Trizivir?
5Patient Review
10/12/2007 Trizivir has been a godsend for me. After early intervention of my HIV infection, I have remained quite healthy. My T-Cells range between 400 and 850, and my viral load remains undetectable.
5Patient Review
4/23/2010 I've been taking this medication for a while and it's worked well for me, but my doctor is changing me to Atripla. I'm scared to change because I've been taking this a long time. I am hoping the benefits are better. This medication can cause heart disease my doctor told me, so I am changing. My first dose on Atripla was last night and felt a little weird this morning but I feel better this afternoon..
Patient Q&A Section about trizivir
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is abacavir used for?
"Abacavir is used in conjunction with other medications to treat human immunodeficiency virus (HIV) infection. Abacavir is part of a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It functions by decreasing the amount of HIV in the blood."
Answered by AI
What is Trizivir used for?
"This medication is used to treat adults who are infected with human immunodeficiency virus (HIV), the virus that causes acquired immune deficiency syndrome (AIDS). It is used to replace treatment with the three active substances (abacavir, lamivudine and zidovudine) taken separately at doses similar to those in Trizivir."
Answered by AI
Can abacavir be taken alone?
"This combination of drugs is used to treat HIV infection, either on its own or with other medications."
Answered by AI
When is Triumeq generic?
"Generic versions of Triumeq may not be available until December 8, 2029, due to patent and regulatory protections."
Answered by AI