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What is Triumeq
LamivudineThe Generic name of this drug
Treatment SummaryAbacavir (ABC) is a medication used to treat HIV and AIDS. It is a synthetic chemical compound that works by blocking the enzyme reverse transcriptase, which is used by HIV to replicate. Abacavir is available as an oral tablet and is broken down in the body to its active form, abacavir sulfate.
Epiviris the brand name
Triumeq Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Epivir
Lamivudine
1995
178
Approved as Treatment by the FDA
Lamivudine, otherwise called Epivir, is approved by the FDA for 3 uses which include Chronic Hepatitis B Infection and HIV .Chronic Hepatitis B Infection
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Abacavir
HIV
Effectiveness
How Triumeq Affects PatientsAbacavir is a medication used to treat HIV-1. It works by stopping the virus from reproducing by hindering its ability to make copies of itself. The drug has been shown to be effective at concentrations ranging from 0.07 to 5.8 micro-moles per liter of blood. Abacavir is known to be particularly effective when taken with the drugs zidovudine, nevirapine, amprenavir, didanosine, emtricitabine, lamivudine, stavudine, tenofovir, and zalcitabine.
How Triumeq works in the bodyAbacavir is an antiviral drug used to treat HIV-1. It works by blocking the activity of the virus's reverse transcriptase enzyme. Abacavir is converted into its active form, carbovir triphosphate, by the body's enzymes. This active form replaces the natural substrate dGTP and stops the virus from growing by preventing the formation of the necessary phosphodiester linkages in its DNA.
When to interrupt dosage
The given amount of Triumeq is contingent upon the diagnosed condition. The dosage can be found in the table beneath, contingent upon the technique of delivery (e.g. Oral or Tablet, film coated - Oral).Condition
Dosage
Administration
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Hepatitis B Infection
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Anti-Retroviral Agents
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
treatment failure
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Triumeq has three explicit contraindications, thus it should not be taken in the presence of any of the conditions in the following table.There are 20 known major drug interactions with Triumeq.Common Triumeq Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Lamivudine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Lamivudine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Lamivudine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Lamivudine may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Minor
Lamivudine may decrease the excretion rate of Almasilate which could result in a higher serum level.
Triumeq Toxicity & Overdose RiskStudies on rats and mice have shown some heart damage. The most common side effects in adults during HIV-1 treatment include feeling sick, headaches, tiredness, nausea and vomiting, and problems sleeping. Severe allergic reactions have been associated with abacavir, and are more likely if the patient has a certain gene (HLA-B*57:01). People should be tested for this gene before starting abacavir treatment, as recommended by the FDA.
Triumeq Novel Uses: Which Conditions Have a Clinical Trial Featuring Triumeq?
43 active studies are presently investigating the potential of Triumeq in combating HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Treatment Naive
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Triumeq Reviews: What are patients saying about Triumeq?
5Patient Review
6/8/2016 After my HIV diagnosis in 2015, I was put on Truvada. Six weeks later, we switched to Triumeq and I haven't had a detectable viral load since. Additionally, I experienced zero negative side effects from the medication.
5Patient Review
6/30/2015 I've been on this medication for 25 years, and it's by far the easiest (1 pill) with the least amount of side effects.
5Patient Review
3/3/2015 These drugs really helped me out and I'm grateful for them.
5Patient Review
10/21/2015 I didn't experience any negative side effects.
5Patient Review
1/16/2018 I was diagnosed with HIV in December of 2017 and have been on this medication for five days. I feel great--no side effects whatsoever. I haven't had my blood work done yet to see if it's working, but I'm sure it is. Thank you!
4.7Patient Review
3/13/2019 I had a great experience with this treatment; the only exception being appendicitis a few months after I started taking the medication. There have been a few similar cases, but no other reported side effects that I'm aware of. This was my first treatment and it's been just over a year now. My viral load was undetectable within two months of starting the regimen.
Patient Q&A Section about triumeq
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Triumeq used to treat?
"This product contains three drugs which are designed to help control and decrease the amount of HIV in an individual's body so that their immune system can work more effectively."
Answered by AI
What type of drug is Triumeq?
"Triumeq is an HIV medication that combines three antiretroviral drugs into one pill that is taken once a day. The drugs in Triumeq are dolutegravir (50mg), abacavir (600mg), and lamivudine (300mg). Triumeq is an oval, film-coated purple tablet that has '572 Tri' on one side."
Answered by AI
Is Triumeq the same as Biktarvy?
"The side effects of Triumeq that are different from Biktarvy are vomiting, fever, loss of appetite, low energy, abnormal body fat distribution, numbness and tingling, hypersensitivity reactions (fever, rash, shortness of breath, cough or sore throat), joint pain or swelling, muscle pain, extremity swelling, depression."
Answered by AI
How effective is Triumeq?
"Triumeq is very effective in reducing the amount of HIV in the blood. In trials, 88% of people who took it every day had an undetectable viral load after 48 weeks."
Answered by AI