Your session is about to expire
What is Trintellix
VortioxetineThe Generic name of this drug
Treatment SummaryVortioxetine is an antidepressant medication used to treat major depressive disorder (MDD). It works by targeting multiple serotonin receptors in the brain to increase levels of the mood-regulating neurotransmitter. This drug acts as a serotonin reuptake inhibitor, meaning that it blocks the uptake of serotonin by nerve cells, and it also acts as a partial agonist of certain serotonin receptors. Vortioxetine was designed to be more effective than traditional antidepressants by targeting multiple serotonin receptors instead of just one.
Trintellixis the brand name
Trintellix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trintellix
Vortioxetine
2013
13
Effectiveness
How Trintellix Affects PatientsVortioxetine is designed to interact with the serotonin transporter in the brain. It binds very strongly to this transporter, but not to others such as the norepinephrine or dopamine transporters. It also interacts with five different types of serotonin receptors, blocking some and partially activating others, in order to regulate serotonin levels in the brain.
How Trintellix works in the bodyVortioxetine works on the serotonin system in several ways. It acts as an inhibitor of the serotonin transporter, which helps keep serotonin in the brain longer. It also acts as a partial activator of certain serotonin receptors, while blocking some others. This helps balance the activity of serotonin in the brain, promoting a healthy state.
When to interrupt dosage
The encouraged dosage of Trintellix is contingent upon the identified circumstance. The amount of dosage differs, as per the mode of administration (e.g. Tablet, film coated - Oral or Tablet) as featured in the table beneath.Condition
Dosage
Administration
Depression
, 5.0 mg, 10.0 mg, 15.0 mg, 20.0 mg, 20.0 mg/mL
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Trintellix.Common Trintellix Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Vortioxetine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Vortioxetine.
Apomorphine
Major
The risk or severity of hypotension can be increased when Vortioxetine is combined with Apomorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Vortioxetine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Vortioxetine.
Trintellix Toxicity & Overdose RiskCommon side effects of using this drug include nausea, diarrhea, and a dry mouth. The FDA also issued a warning about potentially dangerous reactions, such as serotonin syndrome, increased risk of abnormal bleeding, mania/hypomania, low sodium levels, and suicidal thoughts in children, teenagers, and young adults.
Trintellix Novel Uses: Which Conditions Have a Clinical Trial Featuring Trintellix?
186 active clinical trials are studying the potential of Trintellix to manage the symptoms of Depression.Condition
Clinical Trials
Trial Phases
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Trintellix Reviews: What are patients saying about Trintellix?
5Patient Review
7/7/2022 I felt great for a few days after first taking this medication, then slipped back into depression for four weeks. I'm now on week five and feeling truly not depressed, just excited and motivated. The difference this Trintellix has made in my life is drastic; it really saved me from a painful existence.
5Patient Review
9/20/2022 I had some mild nausea when I first started the treatment, but it quickly subsided. This has been by far the best medication that I've tried.
5Patient Review
6/13/2022 I am feeling so much better since I started taking this medication. I had been in a major depressive episode for 10 months before starting this treatment, and it has only been a week. I'm excited to wake up again and have happy mood throughout the day. It's amazing.
4Patient Review
9/15/2022 Out of the seven different medications I've tried, this one has helped me the most. However, it can be expensive because there is no generic version available. Additionally, I experienced fewer sexual side effects with this medication than with others.
2.3Patient Review
10/1/2022 I found this script made me really emotional and unable to sleep, on top of being quite expensive.
2.3Patient Review
6/13/2022 I was on a lower dose of this medicine and it worked well for a few months, but once my doctor increased the dosage to 20 mg I started having really intense suicidal thoughts. I'm in the process of getting off this medication now.
1Patient Review
8/1/2022 I became an absolute monster on this drug, yelling and cussing at people I knew and didn't know. Can't sleep and weaning off ASAP. Depression and anxiety were preferable to the rage I feel now.
Patient Q&A Section about trintellix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Trintellix good for anxiety and depression?
"The text states that, in general, the anxiety and depression reducing qualities of the subject have been shown to be effective for people who have major depressive disorder or high levels of anxiety."
Answered by AI
What does the drug Trintellix do?
"Trintellix (vortioxetine) is a prescription drug used to treat major depressive disorder in adults."
Answered by AI
What are the side effects of Trintellix?
"Some of the potential side effects of this medication include nausea, diarrhea, dry mouth, constipation, vomiting, gas, dizziness, and abnormal dreams."
Answered by AI
How is Trintellix different from other antidepressants?
"Trintellix is unique among antidepressants currently on the market in that it directly affects serotonin receptors in addition to inhibiting serotonin reuptake. Trintellix is much less likely to cause weight gain than other types of antidepressants, such as tricyclic antidepressants, MAOIs, or SSRIs."
Answered by AI