Tri-Legest Fe

Endometriosis, Low Testosterone, Osteoporosis + 16 more
Treatment
20 Active Studies for Tri-Legest Fe

What is Tri-Legest Fe

NorethisteroneThe Generic name of this drug
Treatment SummaryEthinylestradiol was developed in 1938 and is used as a form of estrogen with improved absorption when taken orally. It is most commonly used in contraceptive pills and was approved by the FDA in 1943.
Neconis the brand name
image of different drug pills on a surface
Tri-Legest Fe Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347

Effectiveness

How Tri-Legest Fe Affects PatientsEthinylestradiol is a type of synthetic hormone (estrogen) that prevents ovulation by decreasing hormones in the body responsible for ovulation. It can be taken once a day and is considered safe, although patients should be aware of the risks of clots.
How Tri-Legest Fe works in the bodyEthinylestradiol is a synthetic estrogen that is used in birth control pills. It works by reducing the hormones needed to ovulate, making the cervical mucus thicker so sperm cannot pass through, and preventing changes in the uterus that would allow a fertilized egg to implant. It also lowers luteinizing hormone levels and increases sex hormone binding globulin.

When to interrupt dosage

The prescribed amount of Tri-Legest Fe is contingent upon the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The dosage likewise changes depending on the administration approach detailed in the table beneath.
Condition
Dosage
Administration
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Ovarian Failure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Postmenopausal Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Tri-Legest Fe has twenty-six contraindications, hence it should not be compounded with any of the conditions enumerated in the following table.Tri-Legest Fe Contraindications
Condition
Risk Level
Notes
active liver disease
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
There are 20 known major drug interactions with Tri-Legest Fe.
Common Tri-Legest Fe Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Tri-Legest Fe Toxicity & Overdose RiskWomen who overdose on contraceptives may experience a lack of normal menstrual bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment of the overdose should include monitoring of potassium and sodium levels in the blood as well as signs of metabolic acidosis.

Tri-Legest Fe Novel Uses: Which Conditions Have a Clinical Trial Featuring Tri-Legest Fe?

38 active clinical trials are examining the potential of Tri-Legest Fe for Folate supplementation, Premenstrual Dysphoric Disorder and Menopausal symptom management.
Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Estrogen Deprivation Symptoms
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Therapeutic procedure
0 Actively Recruiting
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Menopause
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Fracture
0 Actively Recruiting
female castration
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Vasomotor System
0 Actively Recruiting
Endometriosis
1 Actively Recruiting
Phase 4
Ovarian Failure
2 Actively Recruiting
Not Applicable, Phase 1
Hormonal Contraception
0 Actively Recruiting

Tri-Legest Fe Reviews: What are patients saying about Tri-Legest Fe?

5Patient Review
6/3/2014
Tri-Legest Fe for Acne
I experienced no bloating, breast growth, weight gain, or mood swings. My period was also lighter (2-3 days). However, my skin got worse after starting to use it.
5Patient Review
4/13/2016
Tri-Legest Fe for Birth Control
I was really pleased with this treatment--I didn't experience any weight gain, my acne decreased, and my moods were more stable. My period was also lighter than usual, which was an added bonus.
5Patient Review
11/27/2019
Tri-Legest Fe for Birth Control
Though this medication alleviated my period pain and made my periods lighter, after seven months of taking it I experienced increased depression and suicidality. Additionally, it did nothing for my acne.
4.7Patient Review
9/11/2015
Tri-Legest Fe for Birth Control
I took this for acne as well as birth control. The first month I had a lot of side effects such as mood swings, headaches, and the acne got worse. However, after using it for a couple of months all the side effects went away. My breasts grew a little and I didn't gain any weight. My acne persisted for about 6-8 months but then it began to clear up dramatically! Now my skin is better than it has ever been before. Once my body adjusted it worked wonderfully.
4.7Patient Review
11/10/2015
Tri-Legest Fe for Acne
I've only been taking this medication for three weeks, but I'm already seeing results that I like. At first, I felt a little nauseous after taking the pink pills, but now I'm feeling fine. I have more energy and don't feel depressed. This is by far the best birth control option I've tried (IUDs included).
4.7Patient Review
6/23/2016
Tri-Legest Fe for Birth Control
Unfortunately, this pill caused me to break out all over my chin and cheeks. I never had that problem before. Additionally, it made my periods more painful with cramps and bloating.
4.3Patient Review
4/26/2014
Tri-Legest Fe for Birth Control
I tried this generic version of estrostep, and while it was cheaper, I didn't like it as much. I felt bloated and gassy all the time, and my periods were lighter and less regular. I'll be switching back next month.
4.3Patient Review
7/17/2015
Tri-Legest Fe for Acne
I was given the generic form of this drug when my pharmacy was out of estrostep fe, and I have not had a good experience with it. In the two months that I've been taking it, I've gained weight, felt more PMS symptoms, and gotten dizzy spells more frequently. I'm glad to be done with it and going back to the original formulation that I know works well for me.
3.7Patient Review
4/19/2019
Tri-Legest Fe for Painful Periods
This pill did stop my irregular period, however, the side effects were not worth it. I felt dizzy and lightheaded constantly, and the cramps I experienced during my first period on the pill were unbearable.
3.7Patient Review
6/29/2014
Tri-Legest Fe for Birth Control
I'm currently on my third week of pills and have noticed extreme emotional changes. The second week was especially hard in terms of ravenous cravings, but that has since subsided. However, I am now dealing with water retention and painfully swollen breasts.
3.7Patient Review
2/16/2014
Tri-Legest Fe for Birth Control
I've been on this medication for my acne for a while now, and it does a decent job of keeping things under control--though not perfectly. One downside is that I occasionally get breakthrough bleeding a few weeks into each new pack.
3.7Patient Review
5/8/2022
Tri-Legest Fe for Premenstrual Disorder with a State of Unhappiness
I started taking tri legest fe to help with my acne, but it actually made it worse. In addition, I experienced bloating, cramps, fatigue, and increased mood swings and anxiety. The only positive aspect of this medication was that my periods became lighter and shorter. Overall, I would not recommend this birth control to anyone.
3.3Patient Review
9/24/2014
Tri-Legest Fe for Birth Control
While this birth control has been effective in preventing pregnancy, the side effects have been really tough to deal with. Bloating, stomach pain, constipation, and tender breasts are all constant issues I've experienced. Additionally, it made my acne much worse than it was before.
3.3Patient Review
11/11/2013
Tri-Legest Fe for Acne
3.3Patient Review
6/22/2014
Tri-Legest Fe for Birth Control
I really liked Tri Legest Fe. I only stopped taking it because it got too expensive and my new insurance wouldn't cover it. It did a great job reducing my acne, and I didn't have any mood swings while on it. I also didn't gain any weight, which is something that happened when I first started taking birth control (Yaz).
2.7Patient Review
5/21/2015
Tri-Legest Fe for Premenstrual Disorder with a State of Unhappiness
I've been taking this treatment for three months now, and I can say with certainty that it has changed me for the worse. I'm more irritable and quick to anger than ever before, and my anxiety issues have come back with a vengeance. Plus, I haven't wanted to have sex since starting this medication--which was the whole reason I started taking birth control in the first place. Needless to say, I'll be exploring other options from here on out.
2Patient Review
5/10/2016
Tri-Legest Fe for Birth Control
I got pregnant the first month I stopped taking birth control pills, which was great. Not having to worry about messing up my pill schedule or whether or not my body's hormones were aligning properly made things much easier.

Patient Q&A Section about tri-legest fe

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Tri Legest Fe generic for?

"Tri-Legest is a combined oral contraceptive indicated for the prevention of pregnancy. It is a progestin and estrogen combination pill that is taken once daily."

Answered by AI

Is Tilia Fe the same as Tri Legest?

"This text is discussing a generic equivalent to the drug ESTROSTEP Fe. The generic equivalent is called Tri-Legest Fe."

Answered by AI

Is Tri Legest Fe good for acne?

"The medication NORETHINDRONE ACETATE; ETHINYL ESTRADIOL; FERROUS FUMARATE is used to prevent ovulation and pregnancy. It may also be used to treat acne."

Answered by AI

What hormones are in Tri Legest Fe?

"The pill consists of two hormones, norethindrone (a progestin) and ethinyl estradiol (an estrogen), as well as a small amount of iron (ferrous fumarate) in the seven inactive pills taken during the fourth week. The inactive pills don't contain any hormones."

Answered by AI

Clinical Trials for Tri-Legest Fe

Have you considered Tri-Legest Fe clinical trials? We made a collection of clinical trials featuring Tri-Legest Fe, we think they might fit your search criteria.
Have you considered Tri-Legest Fe clinical trials? We made a collection of clinical trials featuring Tri-Legest Fe, we think they might fit your search criteria.
Have you considered Tri-Legest Fe clinical trials? We made a collection of clinical trials featuring Tri-Legest Fe, we think they might fit your search criteria.