Treprostinil

NYHA Functional Class III, refractory to conventional therapy, NYHA class IV + 2 more
Treatment
20 Active Studies for Treprostinil

What is Treprostinil

TreprostinilThe Generic name of this drug
Treatment SummaryTreprostinil is a synthetic medicine used to treat high blood pressure in the lungs. It is similar to a natural hormone found in the body called prostacyclin.
Remodulinis the brand name
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Treprostinil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Remodulin
Treprostinil
2002
47

Effectiveness

How Treprostinil Affects PatientsTreprostinil can widen blood vessels and reduce the amount of platelets that clump together. In animal studies, it was found to reduce the strain on the heart and increase blood flow. In humans, it has been found to cause some short-term changes in heart rate after inhaled doses, but this quickly subsides. Higher concentrations of treprostinil can be reached when it is given subcutaneously or intravenously, but the effect of oral treprostinil on heart rate has not been studied. Taking treprostinil can increase the risk of bleeding, low blood pressure, and bronch
How Treprostinil works in the bodyTreprostinil is a medication used to treat pulmonary arterial hypertension, a lung disease that affects blood pressure. Treprostinil works by activating certain receptors, increasing the activity of certain molecules, and opening potassium channels. This helps relax the blood vessels, lowering blood pressure and preventing clots from forming. Treprostinil can also reduce inflammation.

When to interrupt dosage

The suggested measure of Treprostinil is contingent upon the diagnosed affliction, including those refractory to conventional therapy, Pulmonary Arterial Hypertension and NYHA class IV. The amount also depends on the approach of delivery (e.g. Solution or Inhalant) as listed in the accompanying table.
Condition
Dosage
Administration
refractory to conventional therapy
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
Pulmonary Hypertension
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
NYHA Functional Class III
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
NYHA class IV
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
Pulmonary Arterial Hypertension
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit

Warnings

Treprostinil Contraindications
Condition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
There are 20 known major drug interactions with Treprostinil.
Common Treprostinil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Treprostinil may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Treprostinil.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Treprostinil.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Treprostinil.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Treprostinil.
Treprostinil Toxicity & Overdose RiskOverdosing on treprostinil may cause flushing, headache, nausea, vomiting, diarrhea, and low blood pressure. If a patient receives too much treprostinil through an infusion pump, they may experience more severe symptoms, including seizures. In animal studies, treprostinil was not found to be carcinogenic, nor did it have any effect on fertility or mutation. No significant increase in tumors was seen in rats given high doses of oral treprostinil diolamine.
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Treprostinil Novel Uses: Which Conditions Have a Clinical Trial Featuring Treprostinil?

54 active trials are presently running to investigate the utility of Treprostinil in treating Pulmonary Arterial Hypertension, NYHA Functional Class III, and Pulmonary Arterial Hypertensive conditions.
Condition
Clinical Trials
Trial Phases
NYHA class IV
0 Actively Recruiting
NYHA Functional Class III
0 Actively Recruiting
refractory to conventional therapy
0 Actively Recruiting
Pulmonary Hypertension
30 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Early Phase 1
Pulmonary Arterial Hypertension
4 Actively Recruiting
Phase 1, Not Applicable, Phase 2

Treprostinil Reviews: What are patients saying about Treprostinil?

3.7Patient Review
3/22/2017
Treprostinil for Pulmonary Arterial Hypertension
While the side effects can be tough, I definitely saw an improvement in my breathing. My doctor had to make some changes to how often I increased my dosage, but it seems to be working now.
1.3Patient Review
8/8/2018
Treprostinil for Pulmonary Arterial Hypertension
Ever since I started taking this medication, I've been dealing with nonstop pain. It's terrible and makes it hard to tell if the drug is actually working or not.
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Patient Q&A Section about treprostinil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is treprostinil used for?

"Treprostinil is used to treat the symptoms of pulmonary arterial hypertension (PAH) and pulmonary hypertension with interstitial lung disease (PH-ILD) by inhaling it. This will help improve exercise ability."

Answered by AI

What is the brand name for treprostinil?

"Treprostinil is used to treat pulmonary arterial hypertension and comes in three forms: infusion, oral, and inhalation. The brand names for treprostinil are Remodulin, Orenitram, and Tyvaso, respectively."

Answered by AI

Is treprostinil the same as Remodulin?

"Treprostinil Injection has the same active ingredient, strengths, dosage form and inactive ingredients as Remodulin, but is offered at a lower price with the same level of service and support."

Answered by AI

What class of drug is treprostinil?

"Treprostinil works by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body, which allows blood to flow more easily and improve symptoms such as shortness of breath and tiredness."

Answered by AI

Clinical Trials for Treprostinil

Have you considered Treprostinil clinical trials? We made a collection of clinical trials featuring Treprostinil, we think they might fit your search criteria.
Have you considered Treprostinil clinical trials? We made a collection of clinical trials featuring Treprostinil, we think they might fit your search criteria.
Have you considered Treprostinil clinical trials? We made a collection of clinical trials featuring Treprostinil, we think they might fit your search criteria.
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