This trial is evaluating whether Tazemetostat will improve 1 primary outcome and 1 secondary outcome in patients with Tumors, Solid. Measurement will happen over the course of through study completion, estimated to be 1 year after the last subject enrolled.
This trial requires 40 total participants across 1 different treatment group
This trial involves a single treatment. Tazemetostat is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"No cures exist for any form of cancer (cancer cells persist for hundreds of thousands of years). The best one can hope for is a cure for a tiny percentage of people. What people choose to do next is up to themselves.\n" - Anonymous Online Contributor
"The most common signs in cancer are erythema and scaling, and loss of weight. These signs are more common in older individuals, with a male predominance with cancer." - Anonymous Online Contributor
"The cause of cancer is complicated and multi-factorial, involving environmental (for example, alcohol and chemicals), genetic (for example, inherited risk genes), and epigenetic factors, as well as biological (for example, cancer stem cells). However, we do not possess the technology to fully explore every possible mechanism that might cause cancer." - Anonymous Online Contributor
"Cancer is a group of diseases that may form in any organ. Cancer is made up of many different kinds of cells that grow out of control and invade neighboring tissues, forming a mass of cells. This cancerous growth will invade additional tissues unless it is eliminated by the immune system. Each kind of cell in a mass of cells is unique. For almost all cancer patients, it takes many types of specialized cells to form a tumor." - Anonymous Online Contributor
"Cancer treatment is often by surgical resection or other approaches such as chemotherapy or radiation. In some cases, such as sarcoma, surgery continues to be indicated. In other cases such as multiple myeloma, it may become unnecessary, as will be discussed. Radiotherapy continues to be a mainstay in the treatment of a wide variety of cancers." - Anonymous Online Contributor
"Approximately 2.8 million cases of cancer is diagnosed yearly in the United States. Lung cancer (1/6), and cancer of the breast are two cancers that are the most common cause of cancer related deaths." - Anonymous Online Contributor
"Tazemetostat is a novel histone deacetylase inhibitor that merits further investigation for its potential for treating non-Hodgkin's lymphoma. This drug acts by deacetylating histones with a preference for hypoacetylated lysine residues in promoters of tumor cells, allowing transcription factors to bind to the DNA, activating genes that make tumor cells more likely to grow and divide." - Anonymous Online Contributor
"If we accept the conclusion of the scientific establishment that there aren’t new discoveries to treat any of the known forms of cancer, then it must be accepted that current treatments only treat the symptoms caused by the cancer, and that is a real disappointment, as it would imply that we know so little about cancer that no better drug or chemotherapy could be created. The fact that our current treatments cannot cure this disease would be more of a setback than just being told there is no new treatments whatsoever." - Anonymous Online Contributor
"Patients with cancer treated with tazemetostat demonstrated improvement in QOL for several parameters of global QOL, fatigue, pain, and sleep disorders. The overall burden of these symptoms remains high and therefore should be addressed on a daily basis within the treatment strategy for cancer." - Anonymous Online Contributor
"Tazemetostat demonstrates an array of activities that are of interest to academic scientists. Its mode of action involves, but is not limited to, inhibition of several enzymes in both the cytosol and mitochondria. Importantly, it appears to be a novel member of the HDACi family of drugs, and this property makes it a valuable tool for dissecting HDAC activities in cells. In addition, tazemetostat has been proven to be an effective therapeutic agent." - Anonymous Online Contributor
"Tazemetostat had no additional antitumor activity but did prevent peripheral blast transformation of myeloid progenitors, which is considered toxic and has led to its withdrawal from the market in the recent past. When used as a mono, the risk of hematological toxicity outweighed any potential benefit." - Anonymous Online Contributor
"There is no doubt that cancer is a major and a highly growing issue at all levels of society. With regard to the medical profession, the medical world is undergoing a transformation, and with the advances in understanding, treatment and prevention of cancer are a step closer to reality. Recent research for cancer focuses on how to control the mutated cells that are responsible for their growth. With new techniques and therapies, cancer patients are beginning to enjoy a relatively better life expectancy. However, as of yet there is no cure for some of the more dangerous forms of cancer, such as the leukemia cell. However, the most common form of cancer (cervical or cervical cancer) was found to be under control within the past 10 years." - Anonymous Online Contributor