Topiramate

Migraine, Caloric Restriction, High cholesterol + 16 more
Treatment
20 Active Studies for Topiramate

What is Topiramate

TopiramateThe Generic name of this drug
Treatment SummaryTopiramate is a medication used to control seizures and prevent migraine headaches. It was first approved by the FDA in 1996 and later approved for migraine prevention in adults in 2004. Topiramate is also used in combination with phentermine to help adults manage their weight. It contains a monosaccharide chemical structure with sulfamate and 40% of its mass is oxygen. Topiramate was originally developed as an antidiabetic drug, but was found to be an effective antiepileptic drug by chance.
Topamaxis the brand name
image of different drug pills on a surface
Topiramate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Topamax
Topiramate
1997
526

Effectiveness

How Topiramate Affects PatientsTopiramate helps to stop seizures and migraine symptoms by calming down the nerve pathways in the brain. However, it can also cause health problems like acid in the blood, changes in mood, suicidal thoughts, and kidney stones. Taking topiramate together with another drug called valproic acid may also cause a low body temperature.
How Topiramate works in the bodySeizures are caused by an uncontrolled electrical discharge in the brain. Topiramate helps to control seizures and migraines by increasing the activity of GABA-A receptors, which are usually inhibitory, and decreasing glutamate activity, which is usually stimulating. It also blocks voltage-dependent sodium channels, preventing seizures from occurring. Lastly, it has been seen to inhibit carbonic anhydrase isozymes, though the impact of this is not yet known.

When to interrupt dosage

The proposed dosage of Topiramate is contingent upon the diagnosed state, for example Seizures, Weight Reduction and Tonic - clonic seizures. The measure can be found in the accompanying table, based on the mode of administration (e.g. Tablet, coated or Tablet).
Condition
Dosage
Administration
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Exercise
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Lennox Gastaut Syndrome
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Alcoholism
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Migraine
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Caloric Restriction
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
High cholesterol
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
at least one weight-related comorbid condition
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Migraine Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Obesity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Seizures
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Type 2 Diabetes
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Hypertensive disease
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Epilepsy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Weight Loss
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
increase in physical activity
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Mood Disorders
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution
Chronic Weight Management therapy
, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Warnings

Topiramate Contraindications
Condition
Risk Level
Notes
Acidosis
Do Not Combine
There are 20 known major drug interactions with Topiramate.
Common Topiramate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Topiramate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Topiramate.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Topiramate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Topiramate.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Topiramate.
Topiramate Toxicity & Overdose RiskThe lowest toxic dose of topiramate in rats is greater than 1500mg/kg. In a study of 4 women taking topiramate, symptoms of overdose ranged from mild to severe, but no deaths were reported. Symptoms of overdose may include low blood pressure, extreme acidity in the body, coma, abdominal pain, vision problems, seizures, drowsiness, difficulty speaking or thinking, confusion or agitation, dizziness, and depression. If the overdose was recent, the stomach contents can be emptied using vomiting or a stomach pump. Treatment may also include activated charcoal and dialysis.
image of a doctor in a lab doing drug, clinical research

Topiramate Novel Uses: Which Conditions Have a Clinical Trial Featuring Topiramate?

313 clinical trials are currently underway to assess the potential of Topiramate to treat Type 2 Diabetes, Migraine and Exercise-related conditions.
Condition
Clinical Trials
Trial Phases
Exercise
60 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Weight Loss
0 Actively Recruiting
Mood Disorders
0 Actively Recruiting
Migraine
54 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Obesity
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Seizures
4 Actively Recruiting
Phase 3, Phase 2
High cholesterol
0 Actively Recruiting
Obesity
0 Actively Recruiting
at least one weight-related comorbid condition
0 Actively Recruiting
Lennox Gastaut Syndrome
3 Actively Recruiting
Phase 2, Phase 1, Phase 4
Obesity
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Epilepsy
0 Actively Recruiting
Alcoholism
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Type 2 Diabetes
177 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
increase in physical activity
0 Actively Recruiting

Topiramate Reviews: What are patients saying about Topiramate?

4.3Patient Review
3/20/2022
Topiramate for Migraine Prevention
I've been taking Topamax for over 15 years and it's really helped me. I know some people can't take the drug, but for me it's been a life-saver. The only downside is that now I have to take the generic form (because of my insurance) and it doesn't work nearly as well.
4Patient Review
2/21/2022
Topiramate for Migraine Prevention
I've been on topimax for 11 years. The only side effect I've experienced is weight loss, which pleases me.
3.7Patient Review
3/25/2022
Topiramate for Migraine Prevention
I've been taking Topiramate for migraines and have experienced some very negative side effects, including depression, anxiety, and diarrhea. I would not recommend this medication to others.
2Patient Review
3/6/2022
Topiramate for Migraine Prevention
After taking the second 25mg dose of Topiramate, I started feeling numb in my face and arms when I woke up. My depression was really bad. After 4 days, I developed closed-angle glaucoma and could have lost my vision permanently if I hadn't gotten help right away.
1.7Patient Review
3/31/2022
Topiramate for Migraine Prevention
I would not recommend this medication to anyone. While it did help with my migraines, the side effects were really severe. I had tingling in my extremities and slurred speech--to the point where my colleagues thought I'd actually had a stroke. Do not take this drug.
View All Reviews
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Patient Q&A Section about topiramate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the serious side effects of topiramate?

"If you experience any of the following side effects, it could be a sign of a more serious condition and you should seek medical attention immediately: pain in your back, belly or side; a burning sensation when you pee; cloudy or smelly pee; feeling sleepy; losing your appetite; or having an irregular heartbeat."

Answered by AI

What is the drug topiramate used for?

"UK Topiramate is a medicine to treat epilepsy and migraine."

Answered by AI

What is the most common side effect of topiramate?

"You may experience fatigue, drowsiness, dizziness, loss of coordination, tingling in your extremities, decreased appetite, bad taste in your mouth, diarrhea, and weight loss."

Answered by AI

What does Topamax do to your body?

"Topiramate is a type of medication used to treat seizures. It works by decreasing the abnormal excitement in the brain."

Answered by AI

Clinical Trials for Topiramate

Have you considered Topiramate clinical trials? We made a collection of clinical trials featuring Topiramate, we think they might fit your search criteria.
Have you considered Topiramate clinical trials? We made a collection of clinical trials featuring Topiramate, we think they might fit your search criteria.
Have you considered Topiramate clinical trials? We made a collection of clinical trials featuring Topiramate, we think they might fit your search criteria.
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