Topiramate

Migraine, Caloric Restriction, High cholesterol + 16 more

Treatment

20 Active Studies for Topiramate

Treatment for

Migraine

What is Topiramate

TopiramateThe Generic name of this drug

Treatment SummaryTopiramate is a medication used to control seizures and prevent migraine headaches. It was first approved by the FDA in 1996 and later approved for migraine prevention in adults in 2004. Topiramate is also used in combination with phentermine to help adults manage their weight. It contains a monosaccharide chemical structure with sulfamate and 40% of its mass is oxygen. Topiramate was originally developed as an antidiabetic drug, but was found to be an effective antiepileptic drug by chance.

Topamaxis the brand name

image of different drug pills on a surface

Topiramate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Topamax

Topiramate

1997

526

Effectiveness

How Topiramate Affects PatientsTopiramate helps to stop seizures and migraine symptoms by calming down the nerve pathways in the brain. However, it can also cause health problems like acid in the blood, changes in mood, suicidal thoughts, and kidney stones. Taking topiramate together with another drug called valproic acid may also cause a low body temperature.

How Topiramate works in the bodySeizures are caused by an uncontrolled electrical discharge in the brain. Topiramate helps to control seizures and migraines by increasing the activity of GABA-A receptors, which are usually inhibitory, and decreasing glutamate activity, which is usually stimulating. It also blocks voltage-dependent sodium channels, preventing seizures from occurring. Lastly, it has been seen to inhibit carbonic anhydrase isozymes, though the impact of this is not yet known.

When to interrupt dosage

The proposed dosage of Topiramate is contingent upon the diagnosed state, for example Seizures, Weight Reduction and Tonic - clonic seizures. The measure can be found in the accompanying table, based on the mode of administration (e.g. Tablet, coated or Tablet).

Condition

Dosage

Administration

Alcoholism

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

High cholesterol

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

at least one weight-related comorbid condition

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

prophylaxis of migraine headaches

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Type 2 Diabetes

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Hypertensive disease

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Caloric Restriction

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Weight Reduction

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Lennox Gastaut Syndrome (LGS)

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

increase in physical activity

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Obesity

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Chronic Weight Management therapy

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Exercise

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

BMI >27 kg/m2

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Weight

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Seizures

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Epilepsy

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Mood Disorders

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Migraine

, 25.0 mg, 100.0 mg, 200.0 mg, 50.0 mg, 150.0 mg, 15.0 mg, 23.0 mg, 46.0 mg, 69.0 mg, 92.0 mg, 25.0 meq, 25.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Capsule, Capsule - Oral, Solution - Oral, Solution

Warnings

Topiramate Contraindications

Condition

Risk Level

Notes

Metabolic Acidosis

Do Not Combine

There are 20 known major drug interactions with Topiramate.

Common Topiramate Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Topiramate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Topiramate.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be increased when combined with Topiramate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Topiramate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Topiramate.

Topiramate Toxicity & Overdose RiskThe lowest toxic dose of topiramate in rats is greater than 1500mg/kg. In a study of 4 women taking topiramate, symptoms of overdose ranged from mild to severe, but no deaths were reported. Symptoms of overdose may include low blood pressure, extreme acidity in the body, coma, abdominal pain, vision problems, seizures, drowsiness, difficulty speaking or thinking, confusion or agitation, dizziness, and depression. If the overdose was recent, the stomach contents can be emptied using vomiting or a stomach pump. Treatment may also include activated charcoal and dialysis.

image of a doctor in a lab doing drug, clinical research

Topiramate Novel Uses: Which Conditions Have a Clinical Trial Featuring Topiramate?

313 clinical trials are currently underway to assess the potential of Topiramate to treat Type 2 Diabetes, Migraine and Exercise-related conditions.

Condition

Clinical Trials

Trial Phases

prophylaxis of migraine headaches

0 Actively Recruiting

Weight

0 Actively Recruiting

Migraine

52 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Hypertensive disease

19 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

High cholesterol

4 Actively Recruiting

Phase 2, Phase 1

Type 2 Diabetes

193 Actively Recruiting

Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3

Seizures

2 Actively Recruiting

Phase 3

increase in physical activity

0 Actively Recruiting

Caloric Restriction

0 Actively Recruiting

Chronic Weight Management therapy

0 Actively Recruiting

BMI >27 kg/m2

0 Actively Recruiting

Weight Reduction

1 Actively Recruiting

Not Applicable

at least one weight-related comorbid condition

0 Actively Recruiting

Epilepsy

0 Actively Recruiting

Obesity

0 Actively Recruiting

Alcoholism

7 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Mood Disorders

1 Actively Recruiting

Not Applicable

Lennox Gastaut Syndrome (LGS)

3 Actively Recruiting

Phase 2, Phase 3

Exercise

54 Actively Recruiting

Phase 1, Not Applicable, Phase 2, Phase 3

Topiramate Reviews: What are patients saying about Topiramate?

4.3Patient Review

3/20/2022

Topiramate for Migraine Prevention

I've been taking Topamax for over 15 years and it's really helped me. I know some people can't take the drug, but for me it's been a life-saver. The only downside is that now I have to take the generic form (because of my insurance) and it doesn't work nearly as well.

4Patient Review

2/21/2022

Topiramate for Migraine Prevention

I've been on topimax for 11 years. The only side effect I've experienced is weight loss, which pleases me.

3.7Patient Review

3/25/2022

Topiramate for Migraine Prevention

I've been taking Topiramate for migraines and have experienced some very negative side effects, including depression, anxiety, and diarrhea. I would not recommend this medication to others.

2Patient Review

3/6/2022

Topiramate for Migraine Prevention

After taking the second 25mg dose of Topiramate, I started feeling numb in my face and arms when I woke up. My depression was really bad. After 4 days, I developed closed-angle glaucoma and could have lost my vision permanently if I hadn't gotten help right away.

1.7Patient Review

3/31/2022

Topiramate for Migraine Prevention

I would not recommend this medication to anyone. While it did help with my migraines, the side effects were really severe. I had tingling in my extremities and slurred speech--to the point where my colleagues thought I'd actually had a stroke. Do not take this drug.

1Patient Review

4/29/2022

Topiramate for Tonic-Clonic Epilepsy

I've been on 25 mg of this medication for one month now, and it has really messed with my taste buds, sleep patterns, and mouth. I constantly have headaches (which the doctor says are not migraines) and feel like bugs are crawling all over me. She is slowly weaning me off of the medication, but it has been a nightmare.

1Patient Review

5/2/2022

Topiramate for Migraine Prevention

After taking just two doses of this medication, I started feeling tingling and numbness. Additionally, I felt scared and my brain fogged up. Plus, my eyes started feeling weird too. Needless to say, I won't be taking anymore of this drug; it's straight in the trash.

1Patient Review

5/9/2022

Topiramate for Migraine Prevention

I am a 54 year old healthy female who started taking topiramate 25 mg 2 weeks ago for chronic migraines. I have felt horrible since then. My eyes feel heavy, I have a weird head feeling, and I'm more depressed than ever. I also feel like I have a head cold and my thinking is not clear. I am going no further with this medicine because it has caused me a lot of pain both mentally and physically.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about topiramate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the serious side effects of topiramate?

"If you experience any of the following side effects, it could be a sign of a more serious condition and you should seek medical attention immediately: pain in your back, belly or side; a burning sensation when you pee; cloudy or smelly pee; feeling sleepy; losing your appetite; or having an irregular heartbeat."

Answered by AI

What is the drug topiramate used for?

"UK Topiramate is a medicine to treat epilepsy and migraine."

Answered by AI

What is the most common side effect of topiramate?

"You may experience fatigue, drowsiness, dizziness, loss of coordination, tingling in your extremities, decreased appetite, bad taste in your mouth, diarrhea, and weight loss."

Answered by AI

What does Topamax do to your body?

"Topiramate is a type of medication used to treat seizures. It works by decreasing the abnormal excitement in the brain."

Answered by AI

Clinical Trials for Topiramate

Image of Rowan University in Glassboro, United States.

Project WHADE: A Partner-Based Physical Activity Program for Women

This trial aims to test a new way of encouraging physical activity in women aged 40-65 with heart disease risk factors. Each participant gets a physical activity coach and a partner to support each other in

Rowan UniversityDanielle Arigo, Ph.D.

Image of Northwestern University Feinberg School of Medicine in Chicago, United States.

FoodSteps for Binge Eating

This trial aims to test a new mobile app that helps people with binge eating, diabetes, and food insecurity. The goal is to see if the app is easy to use, well-liked, and

Northwestern University Feinberg School of Medicine

Image of Arizona State University in Phoenix, United States.

Smart Walk for Sedentary Lifestyle

This trial aims to test a smartphone app that is customized for African American women to help them be more active and lower their risk of heart disease and type 2 diabetes.

Arizona State University

Image of Mount Sinai Morningside in New York, United States.

High Fructose Diet for Type 2 Diabetes

This trial aims to understand how high fructose consumption affects metabolic health by studying its impact on the gut microbiome. The research team will investigate how excess fructose may lead to changes in the gut microbi

Waitlist Available

Mount Sinai MorningsideRyan WalkerMetabolic Solutions Inc.

Have you considered Topiramate clinical trials? We made a collection of clinical trials featuring Topiramate, we think they might fit your search criteria.

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Image of Valley Clinical Trials, Inc. in Northridge, United States.

Cagrilintide for Type 2 Diabetes

"This trial will test a new medicine called CagriSema in people with type 2 diabetes to see if it can help lower their blood sugar and body weight. Participants will either receive Cag

Valley Clinical Trials, Inc. (+13 Sites)Clinical Transparency (dept. 2834)Novo Nordisk A/S

Image of NYU Langone Health in New York, United States.

Video-Based Diabetes Self-Management Education and Support (DSMES) for Type 2 Diabetes

This trial aims to see if using video-based education and support for diabetes self-management, either alone or with a community health worker, is more effective than usual care in helping Chinese immigrants in NYC better control

Waitlist Available

NYU Langone HealthLu Hu, PhD

Image of NYU Langone Health in New York, United States.

Diabetes Self-Management Education and Support (DSMES) Videos +1 More for Type 2 Diabetes

This trial aims to study how effective a video-based Diabetes Self-Management Education and Support (DSMES) program, along with community health worker support, is in helping Chinese immigrants with Type 2 diabetes

Waitlist Available

NYU Langone HealthLu Hu, PhD

Image of QPS Miami in Miami, United States.

K-833 +1 More for Obesity

This trial will test how safe and well-tolerated two medications, K-757 and K-833, are when given together to overweight or obese patients with Type 2 diabetes.

No Cost For Treatment

QPS MiamiKallyope Inc.

Have you considered Topiramate clinical trials? We made a collection of clinical trials featuring Topiramate, we think they might fit your search criteria.

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Image of Eccogene Investigational Site in Anaheim, United States.

ECC5004 for Type 2 Diabetes

"This trial is looking at how ECC5004 affects the levels of certain medications (Atorvastatin, Rosuvastatin, Digoxin, and Midazolam) in healthy participants

Eccogene Investigational SiteEccogeneEccogene

Image of University of Michigan in Ann Arbor, United States.

Canagliflozin for Diabetic Kidney Disease

"This trial is looking at the effects of a drug called Canagliflozin on kidney function in people with Type 2 diabetes. They are looking for participants aged 18-80 who have

University of MichiganMarkus Bitzer, MD

Image of Children's Hospital Colorado in Aurora, United States.

Group Program for Type 2 Diabetes

"This trial aims to see if group therapy or diabetes education is better at reducing depression, diabetes stress, and controlling blood sugar in teenagers with Type 2 Diabetes."

Waitlist Available

Children's Hospital Colorado

Image of Brigham and Women's Hospital in Boston, United States.

Digital Navigation for Type 2 Diabetes

This trial aims to see if providing digital literacy training to adult Latino patients with type II diabetes during their hospital admission can help them with their care after leaving the hospital. Participants will receive training on using the

Brigham and Women's Hospital

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