Tobradex St

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

106 FDA approvals

20 Active Studies for Tobradex St

Treatment for

Pemphigus

What is Tobradex St

Dexamethasone

The Generic name of this drug

Treatment Summary

Tobramycin is an antibiotic drug used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria. It is most commonly used to treat chronic Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin can be taken by inhalation, injection, or applied externally to the eye. The drug, which was approved by the FDA in 1975, has some potential side effects such as nephrotoxicity and ototoxicity, but is still a valuable option in the face of antibiotic resistance.

Decadron

is the brand name

image of different drug pills on a surface

Tobradex St Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 106 uses which include Choroiditis and severe Psoriasis .

Choroiditis

Helps manage Choroiditis

severe Psoriasis

Helps manage severe Psoriasis

Drug Allergy

Helps manage Drug hypersensitivity reaction

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Berylliosis

Helps manage Berylliosis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Crohn Disease

Helps manage Regional Enteritis

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Cushing's Syndrome

Serum Sickness

Helps manage Serum Sickness

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Regional Enteritis

Helps manage Regional Enteritis

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Bursitis

Helps manage Bursitis

Cushing Syndrome

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Multiple Myeloma (MM)

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Immune Thrombocytopenia (ITP)

Helps manage Immune Thrombocytopenia (ITP)

Iridocyclitis

Helps manage Iridocyclitis

Optic Neuritis

Helps manage Optic Neuritis

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Choroiditis

Helps manage Choroiditis

Tenosynovitis

Helps manage Tenosynovitis

Asthma

Helps manage Asthma

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Erythroblastopenia

Helps manage Erythroblastopenia

Hypercalcemia

Helps manage Hypercalcemia

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Keratitis

Helps manage Keratitis

Ulcerative Colitis

Helps manage Ulcerative Colitis

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Adrenal Gland Hyperfunction

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Adrenocortical Hyperfunction

Inflammation

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Epicondylitis

Helps manage Epicondylitis

Cancer

Helps manage Cancer

Trichinosis

Helps manage Trichinosis

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Berylliosis

Helps manage Berylliosis

Synovitis

Helps manage Synovitis

Acute Coryza

Helps manage acute rheumatic carditis

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Edema of the cerebrum

Helps manage Edema of the cerebrum

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Atopic Dermatitis

Helps manage Atopic Dermatitis

Severe Seborrheic Dermatitis

Helps manage Severe Seborrheic Dermatitis

Malignant Lymphomas

Helps manage Malignant Lymphomas

exfoliative erythroderma

Helps manage exfoliative erythroderma

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Optic Neuritis

Helps manage Optic Neuritis

Synovitis

Helps manage Synovitis

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Bursitis

Helps manage Bursitis

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Chorioretinitis

Helps manage Chorioretinitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

Contact Dermatitis

Helps manage Contact Dermatitis

Tuberculosis

Helps manage Tuberculosis (TB)

Loeffler's syndrome

Helps manage Loeffler's syndrome

Pemphigus

Helps manage Pemphigus

Uveitis

Helps manage Uveitis

Iritis

Helps manage Iritis

Acute Gouty Arthritis

Helps manage Acute Gouty Arthritis

Hypercalcemia

Helps manage Hypercalcemia

Asthma

Helps manage Asthma

Rosacea

Helps manage Rosacea

Posttraumatic Osteoarthritis

Helps manage Posttraumatic Osteoarthritis

Brain

Helps manage Edema of the cerebrum

Inflammation

Iridocyclitis

Helps manage Iridocyclitis

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Ulcerative Colitis

Helps manage Ulcerative Colitis

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Tobradex St Affects Patients

Tobramycin is an antibiotic that has a wide range of activity against certain bacteria. It is taken up by cells in the kidney and ear, which can cause damage to these areas and lead to side effects like hearing loss, kidney damage, and muscle weakness. It can also cross the placenta, potentially leading to deafness in babies born to mothers who took it during pregnancy. All forms of tobramycin can also cause allergic reactions, including severe skin reactions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

How Tobradex St works in the body

Tobramycin is an antibiotic that kills certain bacteria. It works by binding to the bacterial cells and allowing more of the drug to enter the cell. This increases the permeability of the cell's membrane and causes it to break down. Inside the cell, tobramycin stops the cell from making proteins, which stops the bacteria from reproducing. Bacteria can develop a resistance to tobramycin by making changes to their proteins, or by making changes to tobramycin itself. Tobramycin is not effective against anaerobic bacteria.

When to interrupt dosage

The recommended amount of Tobradex St is contingent upon the diagnosed condition, such as Cystic Fibrosis (CF), steroid-responsive inflammation and Bacterial Meningitis. The quantity of dosage is contingent on the approach of administration as stated in the table below.

Condition

Dosage

Administration

Otitis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Intravitreal, Implant - Intravitreal, Implant, Ointment, Ophthalmic, Ointment - Ophthalmic, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution / drops - Ophthalmic, Tablet, Oral, Tablet - Oral, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Suspension - Auricular (otic), Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Injection, solution - Intravenous, Intravenous, Intra-articular; Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Elixir, Solution / drops, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Auricular (otic); Ophthalmic, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Liquid, Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intravenous, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Liquid - Dental, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution - Oral, Solution, concentrate - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Parenteral, Solution - Parenteral, Injection, solution - Ophthalmic, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Elixir - Oral, Intraocular, Injection, solution - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Ointment - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intra-articular; Intramuscular; Intravenous, Injection, suspension - Intraocular, Insert - Ophthalmic, Insert, Solution - Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Ophthalmic Surgery

Eye

Communicable Diseases

Uveitis

Communicable Diseases

Chorioretinitis

Sarcoidosis

Skin Diseases

Crohn Disease

Retinal Vein Occlusion

swelling of the eyes

Aspiration Pneumonitis

Keloids Scars

Acute Myeloid Leukemia (AML)

Communicable Diseases

Phlyctenular keratoconjunctivitis

Pink Eye

Rheumatoid Arthritis

Urinary Tract Infection (UTI)

Warnings

Tobradex St Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Tobradex St.

Common Tobradex St Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Tobradex St Toxicity & Overdose Risk

Tobramycin can be dangerous in large doses and may lead to kidney damage, hearing loss, nerve or muscle problems, and difficulty breathing. If someone overdoses, symptomatic and supportive treatments should be administered and dialysis may help remove the drug from the body. Fortunately, it is very difficult to overdose on tobramycin due to poor absorption in the digestive tract. Animal studies have found that the lethal dose for mice and rats ranges from 367-1030 mg/kg when given through injections, but it is greater than 7500 mg/kg when taken orally.

image of a doctor in a lab doing drug, clinical research

Tobradex St Novel Uses: Which Conditions Have a Clinical Trial Featuring Tobradex St?

Currently, 8 active trials are in progress to assess the efficacy of Tobradex St in treating Cystic Fibrosis, Ocular Bacterial Infections and Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

58 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1, Phase 4

Asthma

87 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3

Inflammation

56 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3, Phase 4

Acute Coryza

0 Actively Recruiting

Thyroiditis

0 Actively Recruiting

Lupus

65 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Trichinosis

0 Actively Recruiting

Diabetic Macular Edema

19 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Tuberculosis

2 Actively Recruiting

Phase 3, Phase 2

Pulmonary Eosinophilia

7 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 1, Phase 2

Open-angle glaucoma

47 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 1

Uveitis

3 Actively Recruiting

Not Applicable, Phase 3

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Acute Myeloid Leukemia (AML)

32 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3

Thrombocytopenia

0 Actively Recruiting

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Bacterial Infections

0 Actively Recruiting

Atopic Dermatitis

12 Actively Recruiting

Phase 2, Phase 3, Phase 4, Not Applicable

Skin Diseases

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Tobradex St Reviews: What are patients saying about Tobradex St?

Patient Review

6/13/2012

Tobradex St for Inflammation of the Eye

I had an allergic reaction in my eyes and went to the doctor. He prescribed me this medication along with Pataday. I have to say, both of them together really worked well for me and I'm feeling 100% better now.

4.7

Patient Review

3/5/2012

Tobradex St for Severe Inflammation of the Cornea with Rosacea Involvement

This treatment provides temporary relief from the sensation of heat in my eye.

4.7

Patient Review

11/15/2011

Tobradex St for Inflammation of the Front Portion of the Eye

After using this drop for about a week, my eyelid drooped. My doctor acted like it was no big deal and said there's nothing that can be done about it. Predforte has worked for me for almost 20 years with no problems, so I'll stick to that instead.

4.3

Patient Review

3/23/2012

Tobradex St for Allergic Conjunctivitis

This treatment is effectively getting rid of my staph infection, but the drowsiness side effect is really extreme. I've fallen asleep during church service and movies before, which is really embarrassing. Has anyone else experienced this side effect?

Patient Review

1/18/2013

Tobradex St for Scratch Wound on Cornea

There were some mild side effects, like redness and swelling, but they weren't enough to outweigh the benefits. Just be sure to read the directions carefully!

2.3

Patient Review

1/1/2013

Tobradex St for Allergic Conjunctivitis

Unfortunately, I had an allergic reaction to this medication.

Patient Review

7/23/2011

Tobradex St for Inflammation of the Front Portion of the Eye

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tobradex st

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Tobradex ST a steroid?

"Tobradex ST is a combination of tobramycin, an antibiotic, and dexamethasone, a steroid. It is used to treat bacterial infections of the eyes."

Answered by AI

How long should I use Tobradex eye drops?

"Place one drop in each eye that is affected every 4 to 6 hours while the patient is awake. The dosage may be increased to one drop every two hours during the first 24 to 48 hours. Dosing should not exceed 14 days."

Answered by AI

What is the difference between Tobradex and Tobradex ST?

"While TobraDex ST contains half the amount of dexamethasone as the original TobraDex formulation, it appears to be clinically equivalent to the older formulation."

Answered by AI

What is Tobradex ST used for?

"Dexamethasone belongs to a class of drugs called corticosteroids. It works by decreasing inflammation.

This medication is used to treat or prevent eye infections, containing two drugs. Tobramycin, an aminoglycoside antibiotic, works by stopping the growth of bacteria. Dexamethasone, a corticosteroid, works by decreasing inflammation."

Answered by AI