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What is Tetracycline Hydrochloride
TetracyclineThe Generic name of this drug
Treatment SummaryTetracycline is an antibiotic used to treat bacterial infections. It works by binding to the 30S ribosomal subunit of bacteria, blocking incoming amino acid molecules and preventing bacteria from growing. It also affects the bacteria’s cytoplasmic membrane, causing certain parts of the bacteria to leak out.
Tetracycline Hydrochlorideis the brand name
Tetracycline Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tetracycline Hydrochloride
Tetracycline
1975
59
Approved as Treatment by the FDA
Tetracycline, also known as Tetracycline Hydrochloride, is approved by the FDA for 41 uses which include Urinary Tract Infection and Relapsing Fever .Urinary Tract Infection
Relapsing Fever
Necrotizing ulcerative gingivostomatitis
Bacteria
Campylobacter Infection
Anthrax
Bacteria
Trachoma
Disease
Syphilis
Clostridium difficile Infection
Listeriosis
Actinomycosis
Conjunctivitis, Inclusion
Gonorrhea
Typhus
Chancroid
Chlamydia Infections
Yaws
Plague
Tularemia
Granuloma Inguinale
Lymphogranuloma Venereum
Rickettsialpox
Rocky Mountain Spotted Fever
Severe Acne
Bacterial Infections
Klebsiella Infections
Infection, Bacteroides
Shigella Infection
Urinary Tract Infection (UTI)
Bartonellosis
Q Fever
Brucellosis
Escherichia infections
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Metronidazole
Entamoeba histolytica Infection
Acinetobacter Infections
Skin Infections caused by Staphylococcus Aureus
Ornithosis
Psittacosis
Effectiveness
How Tetracycline Hydrochloride Affects PatientsTetracycline is a short-term antibiotic that stops bacteria from multiplying. It does this by attaching to the parts of the bacteria's cells that make proteins, which prevents the bacteria from creating more cells. It can also puncture the outer wall of the bacterial cell and cause the contents inside to leak out, stopping the bacteria from functioning properly.
How Tetracycline Hydrochloride works in the bodyTetracycline works by entering bacteria through small openings in the membrane, and then attaching to their ribosomes. This blocks the ribosomes from making proteins, which stops the bacteria from reproducing.
When to interrupt dosage
The proposed dose of Tetracycline Hydrochloride is contingent upon the recognized condition, such as Bartonellosis, Skin Infections caused by Staphylococcus Aureus and Clostridium difficile Infection (CDI). The amount of dosage depends on the technique of delivery, as detailed in the table below.Condition
Dosage
Administration
Severe Acne
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Typhus
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Acute Glomerulonephritis
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Shigella Infection
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Gonorrhea
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Infection, Bacteroides
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Urinary tract infection
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Yaws
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Bacteria
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Anthrax
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Conjunctivitis, Inclusion
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Prostatitis
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Urinary Tract Infection (UTI)
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Lymphogranuloma Venereum
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Ornithosis
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Necrotizing ulcerative gingivostomatitis
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Listeriosis
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Helicobacter Pylori Infection
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Skin Infections caused by Staphylococcus Aureus
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Granuloma Inguinale
, 250.0 mg, 500.0 mg, 30.0 mg/mL, 0.03 mg/mL, 0.03 mg/mg, 125.0 mg, 1.0 %, 12.7 mg, 1.5 mg/mg, 125.0 mg/mL, 0.01 mg/mg
, Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Kit, Kit - Oral, Ophthalmic, Ointment - Ophthalmic, Tablet, Tablet - Oral, Liquid, Liquid - Oral, Dental, Tablet, film coated, Tablet, film coated - Oral, Syrup, Syrup - Oral, Spray - Topical, Spray
Warnings
There are 20 known major drug interactions with Tetracycline Hydrochloride.Common Tetracycline Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Tetracycline.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Tetracycline.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Tetracycline.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Tetracycline.
Amdinocillin
Major
The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Tetracycline.
Tetracycline Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 808mg/kg when taken orally.
Tetracycline Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Tetracycline Hydrochloride?
Currently, 45 active trials are investigating the potential of Tetracycline Hydrochloride to combat Klebsiella Infections, Rocky Mountain Spotted Fever and Granuloma Inguinale.Condition
Clinical Trials
Trial Phases
Actinomycosis
0 Actively Recruiting
Klebsiella Infections
0 Actively Recruiting
Bartonellosis
0 Actively Recruiting
Lymphogranuloma Venereum
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Relapsing Fever
0 Actively Recruiting
Listeriosis
0 Actively Recruiting
Prostatitis
3 Actively Recruiting
Not Applicable, Phase 4
Tularemia
0 Actively Recruiting
Helicobacter Pylori Infection
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Rocky Mountain Spotted Fever
0 Actively Recruiting
Typhus
0 Actively Recruiting
Plague
0 Actively Recruiting
Rickettsialpox
0 Actively Recruiting
Escherichia infections
0 Actively Recruiting
Necrotizing ulcerative gingivostomatitis
0 Actively Recruiting
Psittacosis
0 Actively Recruiting
Campylobacter Infection
1 Actively Recruiting
Phase 1
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
Patient Q&A Section about tetracycline hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is tetracycline the same as tetracycline hydrochloride?
"The hydrochloride salt of tetracycline, tetracycline hydrochloride, is a broad-spectrum naphthacene antibiotic. It is produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens."
Answered by AI
What bacteria does tetracycline treat?
"Tetracyclines are antibiotics that are effective against a wide range of bacteria, including those that cause chlamydia, mycoplasma, and rickettsia. They are also effective against some parasites."
Answered by AI
What is Tetracycline Hydrochloride used for?
"Tetracycline is an antibiotic that is used to treat a wide variety of infections, including acne. Tetracycline works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as the common cold or flu)."
Answered by AI
Is tetracycline a safe drug?
"Tetracycline is an antibiotic that is taken orally in the form of a capsule. It is safe for use in adults and children who are at least 9 years old. This medication is effective at treating various types of bacterial infections, but it can cause some unpleasant side effects. Tetracycline must be taken multiple times each day to be effective."
Answered by AI