Tensilon

curare overdosage, gallamine triethiodide, curare + 8 more
Treatment
11 FDA approvals
20 Active Studies for Tensilon

What is Tensilon

EdrophoniumThe Generic name of this drug
Treatment SummaryEdrophonium chloride is a drug used to treat irregular heart rhythms and diagnose myasthenia gravis, a rare muscle disorder. It can also be used as an antidote for drugs that block nerve signals, such as curare. Edrophonium chloride works quickly and its effects don't last long.
Enlon Plusis the brand name
image of different drug pills on a surface
Tensilon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enlon Plus
Edrophonium
1991
6

Approved as Treatment by the FDA

Edrophonium, otherwise known as Enlon Plus, is approved by the FDA for 11 uses such as Myasthenia Gravis and curare .
Myasthenia Gravis
curare
tubocurarine
Neuromuscular Blockade
acetone
Respiratory Depression
Used to treat Respiratory Depression in combination with Atropine
curare overdose
Used to treat curare overdose in combination with Atropine
non-depolarizing neuromuscular blocking agents
gallamine triethiodide
curare overdosage
Neuromuscular Blocking Agents
Used to treat nondepolarizing blocking agents in combination with Atropine

Effectiveness

How Tensilon Affects PatientsEdrophonium is a fast-acting medicine that helps to temporarily improve muscle movement. It works by blocking the breakdown of a chemical found in the body called acetylcholine, allowing for more acetylcholine to be available at the sites where it is needed. This is especially useful in people with myasthenia gravis, a condition where the body's immune system attacks some of the body's nerve receptors. By increasing the amount of acetylcholine, edrophonium chloride can help the remaining receptors to work more effectively. The effects can be seen within 30 to 60 seconds and last for about 10 minutes.
How Tensilon works in the bodyEdrophonium helps your body make the most of its natural acetylcholine. It does this by blocking the enzyme that normally breaks down acetylcholine. When acetylcholine is able to stay active for longer, it can stimulate two types of receptors that affect many parts of the body.

When to interrupt dosage

The amount of Tensilon is contingent upon the diagnosed affliction, including Neuromuscular Blocking Agents, non-depolarizing neuromuscular blocking agents and Neuromuscular Blockade. The magnitude of dosage varies, based on the form of delivery (e.g. Injection, solution or Intramuscular; Intravenous) outlined in the table beneath.
Condition
Dosage
Administration
curare overdose
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
curare
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Neuromuscular Blockade
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
non-depolarizing neuromuscular blocking agents
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
acetone
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Neuromuscular Blocking Agents
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
tubocurarine
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Respiratory Depression
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Myasthenia Gravis
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
curare overdosage
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
gallamine triethiodide
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous

Warnings

There are 20 known major drug interactions with Tensilon.
Common Tensilon Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Edrophonium may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetylcholine
Minor
The risk or severity of adverse effects can be increased when Edrophonium is combined with Acetylcholine.
Acrivastine
Minor
Edrophonium may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Agmatine
Minor
The therapeutic efficacy of Agmatine can be decreased when used in combination with Edrophonium.
Albutrepenonacog alfa
Minor
Edrophonium may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Tensilon Toxicity & Overdose RiskTaking too much of this type of drug can lead to cholinergic crisis, in which a person may experience nausea, vomiting, diarrhea, sweating, increased mucus production, and slow heart rate.
image of a doctor in a lab doing drug, clinical research

Tensilon Novel Uses: Which Conditions Have a Clinical Trial Featuring Tensilon?

36 active investigations are being conducted to analyze the potential of Tensilon to address curare, Respiratory Depression and gallamine triethiodide.
Condition
Clinical Trials
Trial Phases
Neuromuscular Blockade
5 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1
non-depolarizing neuromuscular blocking agents
0 Actively Recruiting
tubocurarine
0 Actively Recruiting
Respiratory Depression
0 Actively Recruiting
curare overdosage
0 Actively Recruiting
gallamine triethiodide
0 Actively Recruiting
Neuromuscular Blocking Agents
0 Actively Recruiting
Myasthenia Gravis
27 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
acetone
0 Actively Recruiting
curare
0 Actively Recruiting
curare overdose
0 Actively Recruiting

Tensilon Reviews: What are patients saying about Tensilon?

1Patient Review
4/3/2009
Tensilon for Diagnostic Test for Myasthenia Gravis
Bay Regional Medical Center in Michigan did not have Tensilon available. I'm curious if anyone knows of a place where this medication can be found or what is being used in its stead.

Patient Q&A Section about tensilon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the purpose of Tensilon?

"The Tensilon test is a way for doctors to diagnose myasthenia gravis. Tensilon is a drug that prevents the breakdown of a chemical called acetylcholine. This chemical is important because it helps to stimulate your muscles."

Answered by AI

Is Edrophonium the same as Tensilon?

"The Tensilon test is a quick way to diagnose myasthenia gravis, an autoimmune disease in which the body produces antibodies against acetylcholine receptor proteins.

An Edrophonium test is when a doctor gives a patient a drug that slows the breakdown of acetylcholine. This test is used to help diagnose myasthenia gravis, an autoimmune disease that causes the body to produce antibodies against acetylcholine receptor proteins."

Answered by AI

Is Tensilon still used?

"The Tensilon test has been used to help diagnose MG since the 1930s, but because of the high number of false positives, the U.S. Food and Drug Administration discontinued the use of the drug in 2018. It is no longer used in the U.S. and many other countries."

Answered by AI

How does the Tensilon test work?

"The Tensilon test is a diagnostic test used to evaluate myasthenia gravis, which is a neuromuscular condition characterized by muscle weakness. The test involves an injection of Tensilon (edrophonium) after which your muscle strength is evaluated to determine whether your weakness is caused by myasthenia gravis or not."

Answered by AI

Clinical Trials for Tensilon

Have you considered Tensilon clinical trials? We made a collection of clinical trials featuring Tensilon, we think they might fit your search criteria.
Have you considered Tensilon clinical trials? We made a collection of clinical trials featuring Tensilon, we think they might fit your search criteria.
Have you considered Tensilon clinical trials? We made a collection of clinical trials featuring Tensilon, we think they might fit your search criteria.
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