What is Temovate E
Clobetasol propionateThe Generic name of this drug
Treatment SummaryClobetasol Propionate is a type of steroid medication used to treat inflammatory skin conditions. It is more powerful than other steroids and was first discovered in 1974. It was approved by the FDA in 1985.
Temovate Scalp Applicationis the brand name
Temovate E Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Temovate Scalp Application
Clobetasol propionate
1990
244
Effectiveness
How Temovate E Affects PatientsCorticosteroids, like Clobetasol propionate, help reduce inflammation by blocking certain signals in the body. Generally they are applied twice a day, so their effects last for a long time. The amount of corticosteroid needed to reduce inflammation can be much higher than what the body naturally produces, so it is important for people taking them to be aware of potential side effects like suppression of the hormone system and increased risk of infection.
How Temovate E works in the bodyCorticosteroids reduce inflammation by stopping white blood cells from travelling to the site of inflammation. They also work on gene expression, resulting in downstream effects over time. Glucocorticoids block the creation of certain chemicals that contribute to inflammation, as well as inhibit certain transcription factors. Lower doses reduce inflammation, while higher doses are immunosuppressive. Higher doses also attach to a receptor that increases sodium levels and decreases potassium levels in the body.
When to interrupt dosage
The suggested dose of Temovate E is contingent upon the specified condition, including Psoriasis, corticosteroid responsive, Inflammatory Dermatosis and Pruritus. The amount of dosage can be found in the table below, contingent upon the mode of administration (e.g. Topical or Ointment).Condition
Dosage
Administration
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
corticosteroid responsive, Inflammatory Dermatosis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Pruritus
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Severe Plaque psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Alopecia
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Psoriasis
, 0.4625 mg/mL, 0.0005 mg/mg, 0.5 mg/mL, 50.0 mg/mL, 0.00025 mg/mg, 0.00015 mg/mg, 0.5 mg/mg, 0.0005 mL/mL, 0.462 mg/mL, 0.00005 mg/mg, 0.05 %, 0.0005 mg/mL
Topical, Ointment, Solution - Topical, , Spray, Shampoo - Topical, Cream - Topical, Spray - Topical, Lotion - Topical, Ointment - Topical, Solution, Kit, Aerosol, foam, Cream, Gel - Topical, Aerosol, foam - Topical, Shampoo, Lotion, Emulsion, Aerosol, foam; Kit - Topical, Emulsion - Topical, Gel, Kit - Topical, Aerosol, foam; Kit, Liquid - Topical, Liquid
Warnings
There are 20 known major drug interactions with Temovate E.Common Temovate E Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Clobetasol propionate.
Abetimus
Major
The risk or severity of adverse effects can be increased when Clobetasol propionate is combined with Abetimus.
Temovate E Toxicity & Overdose RiskTaking too much clobetasol propionate can lead to temporary disruption of the hormone-producing glands and decreased production of hormones. Long-term, high doses of glucocorticoids can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, stomach ulcers, pancreatitis, muscle weakness, mood changes, psychosis, thinning skin, allergies, acne, increased hair growth, weakened immune system, increased risk of infection, round face, high blood sugar, decreased levels of calcium and phosphorus in the blood, acidosis, inhibited growth, and reduced hormone production from the adrenal
Temovate E Novel Uses: Which Conditions Have a Clinical Trial Featuring Temovate E?
47 active trials are currently evaluating the efficacy of Temovate E in alleviating corticosteroid-responsive Inflammatory Dermatosis, Psoriasis and Alopecia.Condition
Clinical Trials
Trial Phases
Alopecia
48 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 4, Phase 1
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Severe Plaque psoriasis
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Temovate E Reviews: What are patients saying about Temovate E?
5Patient Review
5/25/2010 This ointment was prescribed to me by a dermatologist for an allergic reaction I had to Neosporin. It not only relieved the itchiness but also moisturized my skin so that it could heal. This worked wonders and I would definitely recommend it to others!
Patient Q&A Section about temovate e
Is Temovate cream a steroid?
"The drugs Temovate and Temovate E are powerful steroid creams that are meant to reduce inflammation and itchiness caused by certain skin conditions." - Anonymous Online Contributor
Unverified Answer
How much does Temovate cost without insurance?
"The cost for Temovate topical cream 0.05% ranges from $179-$200 for a supply of 30 grams, depending on the pharmacy you visit." - Anonymous Online Contributor
Unverified Answer
What is Temovate cream used for?
"The purpose of this medication is to treat various skin conditions such as eczema, psoriasis, dermatitis, allergies, and rash. Clobetasol works by reducing the swelling, itching, and redness that can be associated with these conditions. This medication is a very strong (super-high-potency) corticosteroid." - Anonymous Online Contributor
Unverified Answer
Is Temovate prescription only?
"Temovate is a prescription medicine used to treat symptoms of Plaque and Scalp Psoriasis and Corticosteroid-responsive Dermatoses. Temovate may be used alone or with other medication. Temovate belongs to a class of drugs called Corticosteroids, Topical." - Anonymous Online Contributor
Unverified Answer