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What is Tarka
TrandolaprilThe Generic name of this drug
Treatment SummaryTrandolapril is a type of ACE inhibitor drug used to treat high blood pressure and other heart-related conditions. It works by blocking the enzyme ACE which is responsible for converting angiotensin I to angiotensin II, a blood pressure regulating hormone. Trandolapril can be used to lower mild to moderate hypertension, improve survival after a heart attack, treat congestive heart failure, and slow the progression of kidney disease in people with diabetes.
Mavikis the brand name
Tarka Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mavik
Trandolapril
1996
70
Effectiveness
How Tarka Affects PatientsTrandolapril works by blocking the enzyme (ACE) that is part of the body's natural control system for blood pressure and fluid balance (RAAS). This enzyme normally helps to convert a hormone (angiotensin I) into another hormone (angiotensin II), which increases blood pressure. By blocking ACE, trandolapril stops the conversion of angiotensin I to angiotensin II, and this reduces blood pressure. It also prevents the breakdown of a molecule (bradykinin) that naturally causes blood vessels to widen, further reducing blood pressure. Trandolapril does not
How Tarka works in the bodyTrandolapril is used to lower blood pressure. It works by blocking the two parts of an enzyme, called ACE, that helps regulate blood pressure. The two parts, called N and C domains, work in different ways. The C domain helps regulate blood pressure, while the N domain helps with cell differentiation and growth. Trandolapril blocks both domains, but it has a stronger impact on the C domain. As a result, it reduces the amount of a hormone in the body called ATII, which can raise blood pressure. It also increases the amount of another hormone called renin, which helps lower blood pressure.
When to interrupt dosage
The measure of Tarka is contingent upon the diagnosed condition, such as Heart Attack, Left Ventricular Dysfunction and Hypertensive disease. The sum of dosage shifts in line with the administration mode illustrated in the table underneath.Condition
Dosage
Administration
Congestive Heart Failure
4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral
Hypertensive disease
4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral
Heart Attack
4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral
Left Ventricular Dysfunction
4.0 mg, , 1.0 mg, 2.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral
Warnings
Tarka ContraindicationsCondition
Risk Level
Notes
Angioedema
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Type 2 Diabetes
Do Not Combine
Common Tarka Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Trandolapril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Trandolapril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Trandolapril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Trandolapril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Trandolapril.
Tarka Toxicity & Overdose RiskOverdosing on trandolapril is usually associated with dangerously low blood pressure. Common side effects include coughing, headaches, and dizziness. In laboratory tests, the toxic dose of trandolapril was 4875mg/kg in male mice and 3990mg/kg in female mice. In rats, a dose of 5000mg/kg caused death for only 1 male rat out of 5. No mortality was observed in dogs when given a dose of 1000mg/kg and no abnormal signs were observed.
Tarka Novel Uses: Which Conditions Have a Clinical Trial Featuring Tarka?
391 active studies are presently examining the potential of Tarka to ameliorate Hypertensive disease, Left Ventricular Dysfunction and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Left Ventricular Dysfunction
6 Actively Recruiting
Not Applicable, Phase 4
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Tarka Reviews: What are patients saying about Tarka?
5Patient Review
11/30/2009 I've been taking this medication for almost two decades and it's only recently stopped being effective. I'll be going back to the original dosage despite the cost because it was the best option for me.
5Patient Review
1/7/2010 My blood pressure has lowered significantly since taking this medication, but I have also noticed that my hair has started thinning out. Has anyone else experienced this side effect?
5Patient Review
3/21/2016 Tarka helped me a lot over 20 years ago when my blood pressure was incredibly high. It reduced the chest pains and headaches I was experiencing, as well as lowering my blood pressure by about 15%. I still take it twice a day and it's been great!
5Patient Review
3/12/2010 I've been on Tarka for 10 years now and it's helped me a lot with my blood pressure. Every few years I need an increase in dose, but other than that it's been really effective. It is expensive, though, so it would be nice if it was cheaper.
5Patient Review
10/14/2013 This is the only medication that has been able to lower my blood pressure. I've tried several others in the past with no success.
5Patient Review
7/5/2014 The medication is effective, but I have experienced some constipation and hair loss.
5Patient Review
8/18/2014 The only downside is the weight gain and difficulty losing weight.
5Patient Review
10/6/20095Patient Review
9/27/2010 I get drowsy after taking this medication, but it's worth it because it helps with my E.D.
4.7Patient Review
8/10/2010 I'm curious about when a generic version of this drug will be released, and if there are any negative consequences to switching to the generic.
4.7Patient Review
8/4/20094Patient Review
3/14/2011 This didn't work as well as I'd hoped, but it did lower my blood pressure some. I had to take two other blood pressure pills (benicar and bystolic) to get it under control, but if you're just starting out on treatment, this could be a good option for you.
4Patient Review
6/15/2010 Tarka has been effective, but I need a generic pill that does the same.
3.7Patient Review
5/3/2010 Not worth the cost. I switched to the generic version of this drug and saw no improvement in my blood pressure.
3.7Patient Review
10/23/2009 I felt my pulse quicken after taking this medication.
3.3Patient Review
7/16/2010 My blood pressure has gone down since taking this medication, but I've developed a chronic cough and frequently feel lightheaded. When I stopped taking the drug for two weeks, I had more energy and no coughing, headache, or lightheadedness--but my blood pressure came back up. Now I'm trying to lose weight so that maybe I can come off the medication entirely.
3.3Patient Review
9/7/20092.3Patient Review
7/23/20092Patient Review
9/8/2010 I've been taking this medication for a few years. There was only a minor drop in blood pressure when the dosage was increased; however, I'm still not entirely convinced that it's worth the cost.
1.7Patient Review
1/20/2010 This worked for me, but it's quite expensive. I would love to find a cheaper alternative that works just as well.
Patient Q&A Section about tarka
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is tarka?
"Tarka is a cooking technique in which spices are fried in oil or ghee. The spices used in tarka include fenugreek, fennel seeds, and mustard seeds. When these spices are heated, they release their aroma and flavor."
Answered by AI
What is tarka in Indian cooking?
"Tarka is a process that is also called “tempering” or “blooming” that unlocks maximum flavor from spices by frying them in hot fat."
Answered by AI
What is in a tadka?
"Tadka (which is both a noun and verb in Hindi) is made when oil or a fat like ghee is heated in a pan. To this, dried spices (whole, crushed, or ground), other aromatics like garlic or fresh ginger, or leaves like those from a curry tree, are added and briefly warmed."
Answered by AI
Who owns tarka Indian?
"1. What motivated you to become an entrepreneur?
I always had a passion for food and cooking, and I knew that I wanted to turn my passion into a career. I also wanted to create something that would have a positive impact on people's lives, and that's what motivated me to become an entrepreneur.
- What are your biggest challenges as an entrepreneur?
The biggest challenge for me has been finding the right balance between work and life. As an entrepreneur, you're always working, and it can be easy to lose sight of the things that are important to you outside of work. I've had to learn to make time for my family and friends, and to make sure that I'm taking care of myself, both physically and mentally.
- What are your biggest lessons learned as an entrepreneur?
One of the biggest lessons I've learned is that it's important to have a vision for your business, and to be able to articulate that vision to others. I've also learned that it's important to surround yourself with a supportive team, and to delegate tasks to others.
- What are your goals for the future?
My goal is to continue to grow T"
Answered by AI