Symmetrel

influenza A virus, Restless Legs Syndrome (RLS), Parkinson's Disease + 9 more
Treatment
8 FDA approvals
20 Active Studies for Symmetrel

What is Symmetrel

AmantadineThe Generic name of this drug
Treatment SummaryAmantadine is a medication used to prevent and treat influenza A. It can also be used to treat Parkinson's disease, involuntary muscle movements, and nerve pain caused by shingles. It works by increasing the production of dopamine in the brain and blocking its uptake, although the exact mechanism of action is not fully understood.
Symmetrelis the brand name
Symmetrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Symmetrel
Amantadine
1976
103

Approved as Treatment by the FDA

Amantadine, also called Symmetrel, is approved by the FDA for 8 uses like Parkinsonism and Parkinson's Disease .
Parkinsonism
Helps manage Parkinsonism
Parkinson's Disease
Helps manage Parkinson's Disease (PD)
prophylaxis of Influenza A virus infection
influenza A virus
Extrapyramidal Disorders
Dyskinesia
Used in combination with other therapies
Pharmacotherapy
Used in combination with other therapies
Parkinson Disease
Used in combination with other therapies

Effectiveness

How Symmetrel Affects PatientsAmantadine is an antiviral drug that can also be used to treat Parkinson's disease, usually in combination with L-DOPA. It is made from a similar drug called rimantadine and its exact effects are not known. It has been shown to increase the amount of dopamine in the brain, but it does not have anticholinergic properties.
How Symmetrel works in the bodyThe exact way this drug works against Parkinson's Disease is unknown, but it seems to work by increasing the amount of dopamine in the brain. It also blocks certain receptors in the brain related to nerve signals. The way it works against viruses is different; it stops a viral protein called M2 from working, which is necessary for the virus to spread.

When to interrupt dosage

The suggested dose of Symmetrel is dependent on the diagnosed affliction, such as influenza A virus, Restless Legs Syndrome (RLS) and Parkinson's Disease. The amount of dosage is based on the technique of delivery (e.g. Capsule - Oral or Oral), as detailed in the table below.
Condition
Dosage
Administration
Parkinsonism
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
influenza A virus
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Restless Legs Syndrome (RLS)
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Parkinson's Disease
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Parkinsonism post encephalitic
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Extrapyramidal Disorders
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
prophylaxis of Influenza A virus infection
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Huntington Disease
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Multiple Sclerosis
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Cerebral Arteriosclerosis
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Chronic Fatigue Syndrome
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated
Chorea
161.0 mg, 193.0 mg, 129.0 mg, , 50.0 mg/mL, 100.0 mg, 137.0 mg, 1.0 mg/mg, 8.0 mg/mg, 68.5 mg, 258.0 mg, 10.0 mg/mL, 322.0 mg
Capsule - Oral, Oral, Tablet - Oral, Syrup, , Syrup - Oral, Tablet, extended release - Oral, Capsule, gelatin coated, Tablet, extended release, Topical, Capsule, coated pellets, Tablet, film coated - Oral, Kit, Kit - Topical, Capsule, liquid filled, Solution, Capsule, coated pellets - Oral, Solution - Oral, Kit; Tablet, extended release - Oral, Capsule, Capsule, gelatin coated - Oral, Kit; Tablet, extended release, Tablet, Capsule, liquid filled - Oral, Tablet, film coated

Warnings

Symmetrel Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amantadine may interact with Toxoplasma Infections
There are 20 known major drug interactions with Symmetrel.
Common Symmetrel Drug Interactions
Drug Name
Risk Level
Description
Adenovirus type 7 vaccine live
Major
The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Amantadine.
Anthrax vaccine
Major
The therapeutic efficacy of Anthrax vaccine can be decreased when used in combination with Amantadine.
BCG vaccine
Major
The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amantadine.
Bacillus calmette-guerin substrain connaught live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Amantadine.
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Amantadine.
Symmetrel Toxicity & Overdose RiskTaking too much amantadine can be fatal, with the lowest reported lethal dose being 2 grams. Some of the potential side effects of an overdose include irregular heartbeats, difficulty breathing, reduced kidney function, insomnia, anxiety, aggressive behavior, confusion, delirium, hallucinations, lethargy, seizures, and a fever.

Symmetrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Symmetrel?

340 active investigations are underway to assess the potential of Symmetrel for treating Post-Encephalitic Parkinsonism, Parkinsonism and Chorea.
Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
200 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Chronic Fatigue Syndrome
97 Actively Recruiting
Not Applicable, Phase 3, Phase 1, Phase 2, Early Phase 1
Parkinsonism
3 Actively Recruiting
Phase 4
Parkinsonism post encephalitic
0 Actively Recruiting
Chorea
1 Actively Recruiting
Phase 3
influenza A virus
4 Actively Recruiting
Not Applicable, Phase 2
Cerebral Arteriosclerosis
0 Actively Recruiting
prophylaxis of Influenza A virus infection
0 Actively Recruiting
Extrapyramidal Disorders
0 Actively Recruiting
Restless Legs Syndrome (RLS)
1 Actively Recruiting
Not Applicable
Huntington Disease
5 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3
Parkinson's Disease
42 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2

Symmetrel Reviews: What are patients saying about Symmetrel?

4.3Patient Review
2/23/2010
Symmetrel for Fatigue associated with Multiple Sclerosis
I was prescribed this for mental fatigue because of my MS. I've started to become really hypeverbal an hour after taking the dose, twice a day. I also have dysphasia and don't know if it's symmetrical or from the MS. Additionally, I've been itching all over my back--but that could just be dry skin. Another thing is that I haven't had the flu since starting this medication, but I take fiber daily for colitis so who knows if that also keeps me healthy? Anyway, diarrhea is rare for me--just a lot of regular bowel movements............MS spasms or what?
2.7Patient Review
2/7/2008
Symmetrel for A Type of Flu - Influenza A
I'm sorry, but I didn't notice any difference.
2.7Patient Review
6/19/2010
Symmetrel for A Type of Flu - Influenza A
The dizziness this caused was a bit of a problem, but my condition did improve while taking it.
2Patient Review
3/10/2011
Symmetrel for Parkinson's Disease
I haven't had great results with amanadine. I experience chills, fatigue, runny eyes and nose, difficulty sleeping, and heartburn.

Patient Q&A Section about symmetrel

What is Symmetrel prescribed for?

"This medication is used to prevent or treat [influenza](https://www.withpower.com/clinical-trials/influenza) A. If you have been infected with the flu, this medication may help make your symptoms less severe and shorten the time it will take you to get better." - Anonymous Online Contributor

Unverified Answer

How does amantadine make you feel?

"Some people may experience agitation, irritability, or other abnormal behaviors when taking Amantadine. Additionally, it may cause some people to have suicidal thoughts or tendencies, or to become more depressed. If you experience sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared, be sure to tell your doctor." - Anonymous Online Contributor

Unverified Answer

What type of drug is Symmetrel?

"Symmetrel is a prescription medicine that is used to treat the symptoms of Influenza A and Parkinson Disease. Symmetrel can be used by itself or with other medications. Symmetrel belongs to a class of drugs that are called Antiparkinson Agents and Dopamine Agonists; Antivirals, Influenza." - Anonymous Online Contributor

Unverified Answer

What is the drug amantadine used to treat?

"Amantadine is a medicine used to treat Parkinson's disease and its symptoms, including dyskinesia. It may be given alone or in combination with other medicines for Parkinson's disease." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Symmetrel

Have you considered Symmetrel clinical trials? We made a collection of clinical trials featuring Symmetrel, we think they might fit your search criteria.
Have you considered Symmetrel clinical trials? We made a collection of clinical trials featuring Symmetrel, we think they might fit your search criteria.
Have you considered Symmetrel clinical trials? We made a collection of clinical trials featuring Symmetrel, we think they might fit your search criteria.
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