Short vs Standard Duration Radiotherapy for Prostate Cancer
Trial Summary
What is the purpose of this trial?
The purpose of this study is to compare urinary and bowel side effects of hypofractionated radiotherapy in 20 treatments (4 weeks) to ultra-hypofractionated radiotherapy in 5 treatments (2 weeks) for prostate cancer that has returned after prostatectomy. The investigators are also interested in looking at time to progression and the quality of life (health scores).
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment 20 days Radiation therapy, 5 days Radiation Therapy for prostate cancer?
Is short or standard duration radiotherapy for prostate cancer safe?
The research does not provide specific safety data for short or standard duration radiotherapy for prostate cancer, but it mentions potential adverse effects of androgen deprivation therapy (ADT) used with radiotherapy, such as cardiovascular harm, neurocognitive and psychiatric events, and metabolic changes.13678
How does the short vs standard duration radiotherapy treatment for prostate cancer differ from other treatments?
This treatment is unique because it compares a shorter, 5-day radiotherapy schedule to the traditional, longer 20-day schedule, potentially offering similar outcomes with fewer sessions. This approach, known as hypofractionation, delivers higher doses per session over a shorter period, which may be more convenient for patients.1491011
Research Team
Emily Weg, M.D.
Principal Investigator
Weill Medical College of Cornell University
Eligibility Criteria
This trial is for men over 18 with prostate cancer that's come back after surgery. They need a detectable PSA level (unless they have node-positive disease), no distant metastatic disease, and must be able to undergo MRI-guided radiotherapy and fill out a quality of life questionnaire. Men with prior pelvic radiation, inflammatory bowel disease, or other serious cancers can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either hypofractionated radiotherapy over 4 weeks or ultra-hypofractionated radiotherapy over 2 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- 20 days Radiation therapy
- 5 days Radiation Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Weill Medical College of Cornell University
Lead Sponsor
Viewray Inc.
Industry Sponsor