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Thirdhand Smoke Exposure for Healthy Subjects (THS05 Trial)

N/A

Waitlist Available

Led By Suzaynn F Schick, PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Liver function (AST and ALT) in normal ranges

Aged 18-50

Timeline

Screening 3 weeks

Treatment Varies

Follow Up first void, collected for 10 days

Awards & highlights

THS05 Trial Summary

This trial looks at how skin pigment affects how nicotine is absorbed and stored by the body. Initial results suggest darker skin could mean less nicotine uptake.

Who is the study for?

This trial is for healthy adults aged 18-50 with specific skin reflectance scores, normal blood pressure, cholesterol, liver and kidney function. Smokers or those exposed to smoke are excluded, as well as individuals outside the BMI range of 18-35 or with certain medical conditions.Check my eligibility

What is being tested?

The study investigates how melanin in the skin affects absorption and retention of nicotine from clothes exposed to cigarette smoke. Participants will wear these clothes for three hours to see if more melanin means less nicotine uptake and longer retention.See study design

What are the potential side effects?

Since this is an observational study involving wearing clothing exposed to cigarette smoke rather than a drug intervention, direct side effects are not anticipated. However, there may be potential discomfort or minor skin reactions.

THS05 Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My liver tests (AST and ALT) are normal.

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I am between 18 and 50 years old.

THS05 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ first void, collected for 10 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~first void, collected for 10 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and first void, collected for 10 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in blood concentrations of nicotine

Total combined urinary concentrations of the nicotine metabolites cotinine and 3-hydroxycotinine

Secondary outcome measures

Urinary concentration of the NNK metabolite NNAL

THS05 Trial Design

2Treatment groups

Experimental Treatment

Group I: Low melaninExperimental Treatment1 Intervention

Individuals with skin reflectance scores below 150 using the Mexameter 18 instrument.

Group II: High melaninExperimental Treatment1 Intervention

Individuals with skin reflectance scores above 249 using the Mexameter 18 instrument

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor

2,503 Previous Clinical Trials

15,236,595 Total Patients Enrolled

Suzaynn F Schick, PhDPrincipal InvestigatorUniversity of California, San Francisco

1 Previous Clinical Trials

66 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is the ideal demographic for this experiment?

"To be eligible to take part in this clinical trial, participants must possess an optimal state of health and fall between the ages 18-50. The study is currently seeking approximately 60 individuals for enrolment."

Answered by AI

Are individuals of all ages being considered for admission to this experiment?

"This trial is only open to applicants aged 18-50, with 63 studies specifically for minors and 405 for participants over 65 years old."

Answered by AI

Are there any vacancies open in this trial for participants?

"The records on clinicaltrials.gov show that this medical trial is not presently enrolling patients, despite being initially posted and updated on September 1st 2023. Nevertheless, 834 other trials are recruiting participants at the moment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Melanin and Dermal Uptake of Thirdhand Cigarette Smoke

2023. "Melanin and Dermal Uptake of Thirdhand Cigarette Smoke". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06020248.