Sutent

Gastrointestinal Stromal Tumors, Renal Cell Carcinoma
Treatment
10 Active Studies for Sutent

What is Sutent

SunitinibThe Generic name of this drug
Treatment SummarySunitinib is a medication used to treat certain types of cancer, including renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor. It works by blocking several types of receptors that stimulate cell growth in the body. It is taken orally and works by targeting multiple receptor tyrosine kinases, including platelet-derived growth factor receptors, vascular endothelial growth factor receptors, and KIT (CD117), which is responsible for most GISTs. It also blocks other receptor tyrosine kinases such as RET, CSF-1R, and flt3.
Sutentis the brand name
image of different drug pills on a surface
Sutent Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sutent
Sunitinib
2006
26

Effectiveness

How Sutent Affects PatientsSunitinib is a medication taken by mouth that works by blocking certain proteins (known as receptor tyrosine kinases) that help regulate cell growth. It was approved by the FDA on January 26, 2006.
How Sutent works in the bodySunitinib is a drug that helps prevent the growth of tumors, abnormal blood vessel formation, and cancer spreading. Sunitinib works by blocking certain receptor tyrosine kinases (RTKs). These RTKs are responsible for growth factors like platelet-derived and vascular endothelial, stem cell factor, FMS-like tyrosine kinase, colony stimulating factor, and glial cell-line derived neurotrophic factor. Sunitinib has been shown to block these RTKs in biochemical, cellular, and cell proliferation assays. It also has a primary metabolite that has similar effects.

When to interrupt dosage

The prescribed amount of Sutent is contingent upon the recognized state, including unresectable, locally advanced Pancreatic Neuroendocrine Tumors, metastatic Pancreatic Neuroendocrine Tumors and Gastrointestinal Stromal Tumors. The dosage fluctuates, as per the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Renal Cell Carcinoma
12.5 mg, , 50.0 mg, 25.0 mg, 37.5 mg
, Oral, Capsule - Oral, Capsule
Gastrointestinal Stromal Tumors
12.5 mg, , 50.0 mg, 25.0 mg, 37.5 mg
, Oral, Capsule - Oral, Capsule

Warnings

There are 20 known major drug interactions with Sutent.
Common Sutent Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Antilymphocyte immunoglobulin (horse).
Sutent Toxicity & Overdose RiskThe highest dose of this drug that can be given to rats, mice, dogs, and non-human primates, without causing toxicity is more than 500mg/kg for rats, mice, and dogs, and more than 1200mg/kg for non-human primates.
image of a doctor in a lab doing drug, clinical research

Sutent Novel Uses: Which Conditions Have a Clinical Trial Featuring Sutent?

114 active trials are assessing the potential of Sutent in managing unresectable, locally advanced Pancreatic Neuroendocrine Tumors, metastatic Pancreatic Neuroendocrine Tumors and Soft Tissue Sarcoma.
Condition
Clinical Trials
Trial Phases
Gastrointestinal Stromal Tumors
3 Actively Recruiting
Phase 2, Phase 1
Renal Cell Carcinoma
7 Actively Recruiting
Phase 1, Phase 2

Sutent Reviews: What are patients saying about Sutent?

5Patient Review
3/7/2015
Sutent for Cancer Involving the Kidney Cells
Sutent has been an absolute lifesaver for me. I was diagnosed with stage IV metastatic renal cell carcinoma about 18 months ago, and since then the tumors have either disappeared or shrunk to very small sizes. The side effects are unpleasant but manageable, and I would highly recommend this drug to anyone in a similar situation.
5Patient Review
4/29/2014
Sutent for Cancer Involving the Kidney Cells
Though there are some not-so-great side effects that come along with this treatment, I can deal with them. I've been on it for four years now and so far it seems to be working; my next scan is in a week.
5Patient Review
11/25/2015
Sutent for Cancer Involving the Kidney Cells
I've been on Sutent for 4 1/2 years now and it's helped a lot. I originally had 9 nodules in my lungs, but they're all gone now. There are some side effects that come with the medication, but it's still working well overall. I know I'll have cancer until it's gone, but this drug has helped me stay alive and fighting.
5Patient Review
4/10/2015
Sutent for Cancer Involving the Kidney Cells
I had my right kidney removed in 2011, and a PET scan in 2012 showed 4 small tumors. I started taking sutent in February of 2012, at a dosage of 50mg for 2 cycles, 37.5mg for 2 cycles, 25mg for 2 cycles, and 12.5mg for 2 cycles. The PET scan showed no RCC cells present. The side effects were tolerable and I haven't had any major problems.
5Patient Review
3/11/2014
Sutent for Cancer Involving the Kidney Cells
This treatment was great and I would recommend it to others.
View All Reviews
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Patient Q&A Section about sutent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long do cancer patients live with Sutent?

"Sutent resulted in a progression-free survival of 24.1 weeks compared to 6.0 weeks for placebo. For patients specifically with pancreatic neuroendocrine tumors, Sutent resulted in a 10.2 month progression-free survival while placebo resulted in only a 5.4 month progression-free survival."

Answered by AI

What is the drug Sutent used for?

"SUTENT can be used:

-To treat adults with advanced kidney cancer

-To treat adults with GIST that cannot be surgically removed, or has spread to other parts of the body

SUTENT is used to treat advanced pancreatic neuroendocrine tumors and kidney cancer in adults. It can also be used to treat gastrointestinal stromal tumors (GIST) that cannot be surgically removed, or have spread to other parts of the body."

Answered by AI

Does Sutent cure cancer?

"SUTENT slows cancer growth and may prevent cancer cells from spreading by binding to receptors on the cells' surface. SUTENT is not a cure, and not all patients will experience the same results."

Answered by AI

What are the side effects of Sutent?

"Tiredness or weakness, diarrhea, mouth pain, nausea/vomiting, loss of appetite, indigestion, stomach pain, and blisters or rash are all side effects that you and your doctor may be able to manage."

Answered by AI

Is Sutent a chemotherapy?

"Sutent is a cancer treatment that works by inhibiting receptors on the surface of some cells. It is considered a targeted treatment, rather than a traditional chemotherapy drug."

Answered by AI

Clinical Trials for Sutent

Have you considered Sutent clinical trials? We made a collection of clinical trials featuring Sutent, we think they might fit your search criteria.
Have you considered Sutent clinical trials? We made a collection of clinical trials featuring Sutent, we think they might fit your search criteria.
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