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What is Sutent
SunitinibThe Generic name of this drug
Treatment SummarySunitinib is a medication used to treat certain types of cancer, including renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor. It works by blocking several types of receptors that stimulate cell growth in the body. It is taken orally and works by targeting multiple receptor tyrosine kinases, including platelet-derived growth factor receptors, vascular endothelial growth factor receptors, and KIT (CD117), which is responsible for most GISTs. It also blocks other receptor tyrosine kinases such as RET, CSF-1R, and flt3.
Sutentis the brand name
Sutent Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sutent
Sunitinib
2006
26
Effectiveness
How Sutent Affects PatientsSunitinib is a medication taken by mouth that works by blocking certain proteins (known as receptor tyrosine kinases) that help regulate cell growth. It was approved by the FDA on January 26, 2006.
How Sutent works in the bodySunitinib is a drug that helps prevent the growth of tumors, abnormal blood vessel formation, and cancer spreading. Sunitinib works by blocking certain receptor tyrosine kinases (RTKs). These RTKs are responsible for growth factors like platelet-derived and vascular endothelial, stem cell factor, FMS-like tyrosine kinase, colony stimulating factor, and glial cell-line derived neurotrophic factor. Sunitinib has been shown to block these RTKs in biochemical, cellular, and cell proliferation assays. It also has a primary metabolite that has similar effects.
When to interrupt dosage
The prescribed amount of Sutent is contingent upon the recognized state, including unresectable, locally advanced Pancreatic Neuroendocrine Tumors, metastatic Pancreatic Neuroendocrine Tumors and Gastrointestinal Stromal Tumors. The dosage fluctuates, as per the method of delivery featured in the table beneath.Condition
Dosage
Administration
Gastrointestinal Stromal Tumors
12.5 mg, , 50.0 mg, 25.0 mg, 37.5 mg
, Oral, Capsule - Oral, Capsule
Renal Cell Carcinoma
12.5 mg, , 50.0 mg, 25.0 mg, 37.5 mg
, Oral, Capsule - Oral, Capsule
Warnings
There are 20 known major drug interactions with Sutent.Common Sutent Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Sunitinib is combined with Antilymphocyte immunoglobulin (horse).
Sutent Toxicity & Overdose RiskThe highest dose of this drug that can be given to rats, mice, dogs, and non-human primates, without causing toxicity is more than 500mg/kg for rats, mice, and dogs, and more than 1200mg/kg for non-human primates.
Sutent Novel Uses: Which Conditions Have a Clinical Trial Featuring Sutent?
114 active trials are assessing the potential of Sutent in managing unresectable, locally advanced Pancreatic Neuroendocrine Tumors, metastatic Pancreatic Neuroendocrine Tumors and Soft Tissue Sarcoma.Condition
Clinical Trials
Trial Phases
Gastrointestinal Stromal Tumors
6 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Renal Cell Carcinoma
9 Actively Recruiting
Phase 1, Phase 2
Sutent Reviews: What are patients saying about Sutent?
5Patient Review
3/7/2015 Sutent has been an absolute lifesaver for me. I was diagnosed with stage IV metastatic renal cell carcinoma about 18 months ago, and since then the tumors have either disappeared or shrunk to very small sizes. The side effects are unpleasant but manageable, and I would highly recommend this drug to anyone in a similar situation.
5Patient Review
4/29/2014 Though there are some not-so-great side effects that come along with this treatment, I can deal with them. I've been on it for four years now and so far it seems to be working; my next scan is in a week.
5Patient Review
11/25/2015 I've been on Sutent for 4 1/2 years now and it's helped a lot. I originally had 9 nodules in my lungs, but they're all gone now. There are some side effects that come with the medication, but it's still working well overall. I know I'll have cancer until it's gone, but this drug has helped me stay alive and fighting.
5Patient Review
4/10/2015 I had my right kidney removed in 2011, and a PET scan in 2012 showed 4 small tumors. I started taking sutent in February of 2012, at a dosage of 50mg for 2 cycles, 37.5mg for 2 cycles, 25mg for 2 cycles, and 12.5mg for 2 cycles. The PET scan showed no RCC cells present. The side effects were tolerable and I haven't had any major problems.
5Patient Review
3/11/2014 This treatment was great and I would recommend it to others.
4.3Patient Review
5/18/2019 After my right kidney was removed in September 2018, I started taking 50mg of Sutent. Unfortunately, I had to stop after two weeks due to serious side effects. The dosage was then reduced to 37.5 mg and I've been on this for six months, taking a break every other week. Side effects have included a red rash on my scalp, diarrhea, fatigue, and everything tasting salty. Bumps have also appeared on my tongue that are quite sore. Thankfully, treatment is ending on October 24th 2019 and tests show no cancer anywhere else in my body.
4Patient Review
12/20/2013 I've been taking Sutent 50mg for three months as part of my treatment for renal cancer with metastases in the colon and brain. The side effects are significant fatigue, loss of muscle tone, loss of appetite, decreased sense of taste, rectal bleeding, and dry skin. However, the benefits are worth it because my brain tumor has completely disappeared in two months. In other words, this medication has saved my life even though it's tough to deal with on a daily basis.
4Patient Review
11/28/2019 I've had a few small brain tumors removed since starting treatment with Sutent for renal cell carcinoma.
4Patient Review
2/13/2014 I didn't have much of an appetite while taking this medication, and the food I did eat tasted bland.
3.3Patient Review
8/7/2014 I'm only on my third week of this medication, and I've already experienced bad bloating, fatigue, and a sleep disorder.
3.3Patient Review
12/26/2012 I experienced a lot of unpleasant side effects while taking this medication.
Patient Q&A Section about sutent
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long do cancer patients live with Sutent?
"Sutent resulted in a progression-free survival of 24.1 weeks compared to 6.0 weeks for placebo. For patients specifically with pancreatic neuroendocrine tumors, Sutent resulted in a 10.2 month progression-free survival while placebo resulted in only a 5.4 month progression-free survival."
Answered by AI
What is the drug Sutent used for?
"SUTENT can be used:
-To treat adults with advanced kidney cancer
-To treat adults with GIST that cannot be surgically removed, or has spread to other parts of the body
SUTENT is used to treat advanced pancreatic neuroendocrine tumors and kidney cancer in adults. It can also be used to treat gastrointestinal stromal tumors (GIST) that cannot be surgically removed, or have spread to other parts of the body."
Answered by AI