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What is Suprenza
PhentermineThe Generic name of this drug
Treatment SummaryPhentermine is an appetite suppressant drug used for short-term weight management. It was first approved by the FDA in 1959 and is related to amphetamines, although it has a low risk of addiction. Phentermine was initially available as part of a combination drug with fenfluramine and dexfenfluramine, but the combination was discontinued due to reports of abnormal valves in nearly 30% of users. Phentermine is currently available alone or in combination with topiramate, which requires lower doses to achieve the desired effect.
Ionaminis the brand name
Suprenza Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ionamin
Phentermine
1959
298
Approved as Treatment by the FDA
Phentermine, also known as Ionamin, is approved by the FDA for 2 uses including Regime of weight reduction and Comorbidity .Regime of weight reduction
Comorbidity
Used to treat one related comorbidity in combination with Topiramate
Effectiveness
How Suprenza Affects PatientsPhentermine works by suppressing appetite and increasing your metabolism, which helps you lose weight. People using phentermine in clinical studies lost an average of 3.6 kilograms in 2-24 weeks, and were also able to maintain their weight after treatment ended. Phentermine is related to amphetamines, but it does not have the same stimulating effects on your central nervous system, or cause an increase in blood pressure, tolerance, or QTc prolongation.
How Suprenza works in the bodyPhentermine is a medication that works to reduce hunger. It does this by releasing a chemical called noradrenaline in the brain. This chemical activates the body's "fight or flight" response, which cuts down on the hunger signals. Phentermine also blocks another chemical called neuropeptide Y, which is involved in the feeling of hunger. Finally, it is a weak inhibitor of monoamine oxidase, which has a minor effect on hunger levels.
When to interrupt dosage
The prescribed dosage of Suprenza is contingent upon the diagnosed condition, such as Regime of weight reduction, Hyperlipidemia and Type 2 Diabetes. The measure of dosage is subject to the technique of delivery (e.g. Oral or Tablet) laid out in the table below.Condition
Dosage
Administration
increase in physical activity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Type 2 Diabetes
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
High Cholesterol
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Regime of weight reduction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Comorbidity
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Caloric Restriction
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Hypertensive disease
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
BMI >27 kg/m2
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Chronic Weight Management therapy
, 30.0 mg, 15.0 mg, 37.5 mg, 3.75 mg, 7.5 mg, 11.25 mg, 8.0 mg, 18.8 mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release - Oral, Capsule, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Warnings
Suprenza has seven contraindications and should not be used while going through any of the conditions listed in the following table.Suprenza ContraindicationsCondition
Risk Level
Notes
Hyperthyroidism
Do Not Combine
concomitant use or 14 days after discontinuation
Do Not Combine
Agitation
Do Not Combine
Drug abuse
Do Not Combine
Cardiovascular Diseases
Do Not Combine
Open-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phentermine may interact with Pulse Frequency
Common Suprenza Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Phentermine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylene blue
Major
Phentermine may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Phentermine may increase the serotonergic activities of Mirtazapine.
1-benzylimidazole
Minor
The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Phentermine.
4-Methoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Phentermine is combined with 4-Methoxyamphetamine.
Suprenza Toxicity & Overdose RiskIn rats, the lethal dose of phentermine taken orally is 151 mg/kg. Signs of acute overdose include restlessness, tremors, confusion, aggression, hallucinations, rapid breathing, fatigue, and sadness. It can also cause an irregular heartbeat, high or low blood pressure, and gastrointestinal issues such as nausea, vomiting, diarrhea, and stomach cramps. Treatment of an overdose includes symptomatic care and removing the drug from the body. Long-term overdose may cause skin problems, difficulty sleeping, irritability, hyperactivity, and personality changes. It is unknown if phentermine causes cancer or mutations.
Suprenza Novel Uses: Which Conditions Have a Clinical Trial Featuring Suprenza?
Currently, there are 104 active trials investigating the potential of Suprenza in managing Type 2 Diabetes, Weight Loss Regimens and Disease.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
93 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
Regime of weight reduction
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
High Cholesterol
21 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Early Phase 1
BMI >27 kg/m2
0 Actively Recruiting
increase in physical activity
0 Actively Recruiting
Comorbidity
0 Actively Recruiting
Suprenza Reviews: What are patients saying about Suprenza?
4.7Patient Review
5/29/2013 I've been taking this for about a month now, and it's helped me lose 15 pounds. I'm 38 years old with four kids and a demanding job, so this has really helped me take control of my portion sizes and make sure that I'm eating healthy food. The taste is terrible, but I've found that if I let it melt in my mouth instead of swallowing it whole, it works better.
4.7Patient Review
5/21/2013 I've been on Suprenza 30 for 5 weeks and have consistently lost weight each week. So far, I'm down 15lbs total. The only side effect I've noticed is reduced urinary flow, but it's not bad enough for me to stop taking the medication.
4.7Patient Review
4/16/2014 I was on this medication for three months and saw a significant drop in weight. I didn't even need to change my diet or exercise habits!
4.3Patient Review
8/20/2012 This medication is easy to take and very effective.
4Patient Review
8/21/2012 Day 1: I had no appetite and couldn't sleep.
2Patient Review
7/30/20121.7Patient Review
3/27/2013 The taste was incredibly unpleasant, and I saw zero results.
Patient Q&A Section about suprenza
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is phentermine a narcotic?
"Phentermine is an appetite suppressant that is classified as a narcotic in France. It is a combination with topiramate on the horizon."
Answered by AI
What is Suprenza used for?
"Suprenza is a prescription medicine used to treat the symptoms of Obesity by stimulating the central nervous system. Suprenza may be used alone or with other medications."
Answered by AI
Is Suprenza still on the market?
"Suprenza brand name has been discontinued, but there may be generic equivalents available."
Answered by AI
How fast does phentermine work for weight loss?
"Phentermine is taken orally through the gastrointestinal tract and will peak in blood levels in 3-4.4 hours. You should start to feel the effects of the drug around this time, which will include a decreased appetite."
Answered by AI