Sulfasalazine

Proctitis, Colitis, Ulcerative, Arthritis, Juvenile + 4 more

Treatment

20 Active Studies for Sulfasalazine

Treatment for

Proctitis

What is Sulfasalazine

SulfasalazineThe Generic name of this drug

Treatment SummarySulfasalazine is a medication used to treat inflammatory bowel diseases. It works by breaking down in the colon to form 5-aminosalicylic acid, which helps reduce inflammation in the intestines.

Azulfidineis the brand name

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Sulfasalazine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Azulfidine

Sulfasalazine

1950

Effectiveness

How Sulfasalazine Affects PatientsThe way sulfasalazine works is not yet understood, but it may help reduce inflammation and alter the immune system. It is known to reach high concentrations in the liver, serous fluids, and intestines. In patients with ulcerative colitis, it appears that the 5-aminosalicylic acid component is responsible for the therapeutic effect. For those with rheumatoid arthritis, the contribution of sulfasalazine and its metabolites to treatment is currently unknown.

How Sulfasalazine works in the bodySulfasalazine works in the body to reduce inflammation. It does this by blocking certain molecules like leukotrienes and prostaglandins that cause inflammation. It also stops enzymes like phospholipase A2, COX-1 and COX-2, and arachidonate 5-lipoxygenase from working. This stops the inflammation in the body.

When to interrupt dosage

The measure of Sulfasalazine is contingent upon the diagnosed malady, including moderate Ulcerative colitis, Rheumatoid Arthritis and Ulcerative Colitis. The sum of dosage alters as per the delivery process (e.g. Tablet or Enema - Rectal) noted in the table beneath.

Condition

Dosage

Administration

Arthritis, Juvenile

, 500.0 mg, 30.0 mg/mL

, Oral, Tablet, Tablet - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Suspension, Rectal, Suspension - Rectal, Enema, Enema - Rectal, Suppository - Rectal, Tablet, film coated, Tablet, film coated - Oral

Proctitis

, 500.0 mg, 30.0 mg/mL

Colitis, Ulcerative

, 500.0 mg, 30.0 mg/mL

Ulcerative Colitis

, 500.0 mg, 30.0 mg/mL

Rheumatoid Arthritis

, 500.0 mg, 30.0 mg/mL

Crohn's Disease

, 500.0 mg, 30.0 mg/mL

Ulcerative Colitis

, 500.0 mg, 30.0 mg/mL

Warnings

Sulfasalazine has seven known counter-indications, so it should be avoided in the event of any of the conditions laid out in the accompanying table.Sulfasalazine Contraindications

Condition

Risk Level

Notes

Porphyrias

Do Not Combine

Intestines

Do Not Combine

There are 20 known major drug interactions with Sulfasalazine.

Common Sulfasalazine Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Abatacept.

Abetimus

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Acteoside.

Sulfasalazine Toxicity & Overdose RiskStudies on animals have found that sulfasalazine is linked to an increased risk of bladder and kidney tumors in rats, and liver tumors in mice. It has also been linked to fertility problems in male rats, and there are reports of neural tube defects in infants born to mothers who took the drug while pregnant. There have been no studies on pregnant humans but a survey suggests that there is no increase in fetal complications compared to the general population. It is not known how sulfasalazine may affect the growth and development of children exposed to the drug during pregnancy.

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Sulfasalazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulfasalazine?

114 active studies are currently being conducted to investigate the effectiveness of Sulfasalazine in providing relief from Polyarticular juvenile rheumatoid arthritis, chronic or unspecified Ulcerative Colitis and Crohn's Disease.

Condition

Clinical Trials

Trial Phases

Colitis, Ulcerative

0 Actively Recruiting

Proctitis

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Rheumatoid Arthritis

52 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Crohn's Disease

44 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Arthritis, Juvenile

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Sulfasalazine Reviews: What are patients saying about Sulfasalazine?

5Patient Review

6/26/2017

Sulfasalazine for Ulcerative Colitis currently Without Symptoms

Sulfasalazine has been incredibly effective in treating my Colitis flare-ups. I start seeing results within two weeks, and haven't had any issues for the past two months.

4Patient Review

6/22/2017

Sulfasalazine for Collagenous Colitis

I've been using this treatment for a couple years now, and it's made a big difference (I use it three times per day). It's also much cheaper than budesonide.

3Patient Review

5/5/2019

Sulfasalazine for Rheumatic Disease causing Pain & Stiffness in Backbone

I developed a skin rash after using this treatment.

2.7Patient Review

4/16/2019

Sulfasalazine for Rheumatoid Arthritis

Though my pain has decreased significantly, I now feel incredibly exhausted all the time. It's like I just ran a marathon. Has anyone else experienced this?

2Patient Review

9/7/2017

Sulfasalazine for Rheumatoid Arthritis

I've only just started taking this medication.

View All Reviews

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Patient Q&A Section about sulfasalazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sulfasalazine a steroid drug?

"Sulfasalazine (Azulfidine) is not a steroid, but is actually a "steroid-sparing" medication. This means that it helps to manage your condition and symptoms with a lower dose of corticosteroids."

Answered by AI

What are the long term effects of taking sulfasalazine?

"*The most common side-effects of penicillamine were dyspepsia, nausea, and abdominal discomfort, although rashes and macrocytosis also occurred in a small number of patients. Eighteen of the 21 patients treated with penicillamine showed improvement after nine months, although there was some deterioration noted in some patients after one year."

Answered by AI

What does sulfasalazine do to your body?

"Sulfasalazine works to decrease inflammation in the colon and throughout the body by inhibiting the formation of a chemical known as prostaglandins. Prostaglandins have several important functions in the body, one of which is control of pain and inflammation."

Answered by AI

Does sulfasalazine have side effects?

"This is not harmful.

You may experience stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness. If you experience any of these effects, notify your doctor or pharmacist. This medication may cause your skin and urine to turn orange-yellow. This is not harmful."

Answered by AI

Clinical Trials for Sulfasalazine

Have you considered Sulfasalazine clinical trials? We made a collection of clinical trials featuring Sulfasalazine, we think they might fit your search criteria.

Have you considered Sulfasalazine clinical trials? We made a collection of clinical trials featuring Sulfasalazine, we think they might fit your search criteria.