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What is Stimate
NorgestimateThe Generic name of this drug
Treatment SummaryNorgestimate is a medication used in combination with ethinylestradiol to form an oral contraceptive that was developed in 1977. This combined contraceptive can also be used to treat moderate acne. Norgestimate was officially approved by the FDA in December 1989.
Ortho Tri Cyclenis the brand name
Stimate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113
Approved as Treatment by the FDA
Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 8 uses which include Acne Vulgaris and moderate Menopausal Vasomotor Symptoms .Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Effectiveness
How Stimate Affects PatientsNorgestimate is a contraceptive and acne treatment as it stops ovulation and reduces the amount of testosterone in the body. It is considered to be a safe drug, but patients should be aware of the potential risks such as vascular and liver disease, high blood pressure, changes in metabolism, headaches, and irregular bleeding.
How Stimate works in the bodyNorgestimate, a type of progesterone hormone, works by decreasing the amount of hormone released by the brain that stimulates ovulation and testosterone production. This decrease in hormone levels reduces the amount of testosterone available in the body, which in turn helps to reduce symptoms of acne.
When to interrupt dosage
The recommended amount of Stimate relies on the diagnosed condition, including Hypermenorrhea, Postmenopausal Osteoporosis and Menstrual Distress (Dysmenorrhea). The measure of dosage depends on the mode of administration (e.g. Kit or Kit - Oral) as indicated in the table below.Condition
Dosage
Administration
Hypermenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menstrual Distress (Dysmenorrhea)
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Postmenopausal Osteoporosis
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Warnings
Stimate has eleven proscribed contraindications and must not be utilized when experiencing any of the conditions given in the following table.Stimate ContraindicationsCondition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Common Stimate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Stimate Toxicity & Overdose RiskOverdosing on norgestimate is rare, but those who do may require symptomatic and supportive care. Most people who overdose on oral contraceptives do not experience serious harm.
Stimate Novel Uses: Which Conditions Have a Clinical Trial Featuring Stimate?
30 active trials are being conducted to examine the potential of Stimate in treating Postmenopausal Osteoporosis, moderate Vulvovaginal atrophy and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Polycystic Ovarian Syndrome
9 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
moderate Vulvovaginal atrophy
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Hypermenorrhea
0 Actively Recruiting
Menstrual Distress (Dysmenorrhea)
1 Actively Recruiting
Phase 4
Acne Vulgaris
0 Actively Recruiting
Stimate Reviews: What are patients saying about Stimate?
4.3Patient Review
5/1/2017 I've been using this for a while now, and it's been great...until recently. I started to experience some adverse side effects like headaches, flushing, and feeling nauseous after taking it. It honestly feels like I have the flu for a few days afterwards. I'm glad there's something out there to help with my bleeding, but I don't think I'll be using this as often as before due to how terrible I feel after taking it.
4.3Patient Review
7/28/2014 Whenever I take Stimate Nasal Spray, I get a flushed face and laugh at everything. They noticed this in the hospital when they were testing how well Stimate would work with me and told me that it's normal to get "giddy." Now I have dentist's that think I'm high on weed when I go in to get a filling or when I got my wisdom teeth extracted. Other than the dentist's, this thing has worked great for me.
4.3Patient Review
3/16/2008 I have had some negative side effects from using this medication, including feeling ill for a few days afterwards. My blood pressure goes up, I can't sleep, and I become very restless and agitated. However, it is effective in numbing me prior to dental work or surgery.
4Patient Review
10/8/2012 My daughter has von Willebrand's disease, and this medication has been working great for her. She's able to take it without any problems, and it's much easier than the previous medication she was taking (which she wouldn't take because she couldn't stand the taste/texture).
4Patient Review
3/20/2010 I unfortunately experience some negative side-effects, like a headache and general malaise, but it is otherwise an excellent medication.
4Patient Review
9/8/2008 We use this medication frequently for my son's severe nosebleeds. So far, it seems to be working well.
3.7Patient Review
1/22/2011 Though this medication is effective, the side effects are very unpleasant. I often felt nauseous, dizzy, and had headaches. Additionally, hot flashes and increased bleeding were common. To be honest, I would always try to avoid taking it if possible.
3.7Patient Review
11/11/2010 I had a really severe reaction to this drug after my c-section. My sodium levels dropped dangerously low and I was unresponsive for over a day. I ended up in the ICU with brain swelling. If you take this, make sure they closely monitor your sodium levels.
3Patient Review
9/28/2009 Though this medication effectively controls my bleeding, the side-effects are incredibly severe. I once had to go to the hospital because of the vomiting it caused.
Patient Q&A Section about stimate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is there a generic for Stimate?
"The prescription drug Stimate is not currently available in a generic form in the United States."
Answered by AI
Why was Stimate discontinued?
"Ferring Pharmaceuticals has issued a recall of the Stimate (desmopressin) nasal spray due to it containing higher amounts of desmopressin than specified. Stimate is used to treat von Willebrand disease (VWD) and mild hemophilia A."
Answered by AI
Is Stimate still available?
"The product is available in 31 states and can be purchased from STAQ by any pharmacy. NHF, HFA, and the Hemophilia Alliance are working with STAQ to get the product licensed in all 50 states."
Answered by AI