Stilbestrol

Treatment

0 Active Studies for Stilbestrol

What is Stilbestrol

DiethylstilbestrolThe Generic name of this drug

Treatment SummaryDiethylstilbestrol is a man-made estrogen that was previously used to treat menopausal and postmenopausal disorders and to help animals grow. It has been listed as a carcinogen by the National Toxicology Program and should not be used.

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Stilbestrol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Diethylstilbestrol

Effectiveness

How Stilbestrol Affects PatientsDiethylstilbestrol is a man-made hormone that is similar to the female hormone estrogen. In 1971, the FDA warned doctors not to give it to pregnant women since it was linked to a cancer that can develop in daughters of women who used this drug while pregnant.

How Stilbestrol works in the bodyEstrogens work by entering target cells and binding to a protein receptor called the estrogen receptor. These target cells can be found in the reproductive tract, mammary gland, hypothalamus and pituitary. Estrogen binding to these receptors affects the liver's production of proteins like sex hormone binding globulin (SHBG) and thyroid-binding globulin (TBG), as well as suppressing follicle-stimulating hormone (FSH). When combined with a progestin, estrogen can reduce the levels of gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus and pituitary.

Warnings

There are 20 known major drug interactions with Stilbestrol.

Common Stilbestrol Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Diethylstilbestrol.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Diethylstilbestrol.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Diethylstilbestrol.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Diethylstilbestrol.

Anastrozole

Major

The therapeutic efficacy of Anastrozole can be decreased when used in combination with Diethylstilbestrol.

Stilbestrol Toxicity & Overdose RiskOverdosing on this drug can cause nausea and vomiting. In women, withdrawal bleeding may also occur.

Patient Q&A Section about stilbestrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is diethylstilbestrol still used today?

"Diethylstilbestrol is not used often to treat prostate cancer anymore because it has a lot of side-effects. Every once in a while it is used for postmenopausal women with breast cancer. Diethylstilbestrol was used in the past to help animals grow."

Answered by AI

What is Stilboestrol tablets used for in dogs?

"The suppression of lactation in bitches and the treatment of prostatic carcinoma in dogs are both hormone responsive issues. Hormone responsive incontinence is also a problem that can be treated in dogs."

Answered by AI

What are the side effects of stilbestrol in dogs?

"One of the serious side effects of this medication is the development of blood cell abnormalities, which can lead to weakness, fever, bleeding, bruising, bloody diarrhea, or infection. Another serious side effect is the development of uterine infection, which can cause vaginal discharge, vomiting, lack of appetite, excessive water consumption or urination, and/or lethargy. Finally, this medication can also cause the development of mammary tumors."

Answered by AI

What is stilbestrol used for?

"Stilbestrol Tab is a drug that strongly activates the estrogen receptor. It is also used to treat diseases that occur after menopause, prevent miscarriages, or induce early labor in pregnant women at risk. Stilbestrol Tab can be taken with or without food."

Answered by AI