Fetoscopic Laser Photocoagulation for Twin-Twin Transfusion Syndrome
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Fetoscopic Laser Photocoagulation for Twin-Twin Transfusion Syndrome?
Research shows that fetoscopic laser photocoagulation, a minimally invasive surgery, is used to treat twin-to-twin transfusion syndrome by correcting abnormal blood vessel connections in the placenta, which helps regulate blood flow to both babies. Studies from various centers, including those in Brazil and Hong Kong, have reported positive outcomes in managing this condition with this treatment.12345
How is fetoscopic laser photocoagulation different from other treatments for twin-twin transfusion syndrome?
Fetoscopic laser photocoagulation is unique because it is a minimally invasive surgery that uses a small camera and laser to seal off abnormal blood vessel connections in the placenta, which helps regulate blood flow between twins. This approach directly targets the root cause of twin-twin transfusion syndrome, unlike other treatments that may only manage symptoms.34678
What is the purpose of this trial?
The purpose of this study is to evaluate whether the entry technique surgeons use to get inside the uterus to perform fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome has an effect on the rates of chorioamniotic membrane separation.
Research Team
Ahmed Nassr, MD, PhD
Principal Investigator
Baylor College of Medicine
Eligibility Criteria
This trial is for pregnant individuals with monochorionic-diamniotic twin pregnancies experiencing twin-to-twin transfusion syndrome (TTTS) who choose to undergo fetoscopic laser photocoagulation. It excludes those who opt out of the procedure and pregnancies with triplets or more.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Procedure
Participants undergo fetoscopic laser photocoagulation using either direct entry or Seldinger technique
Immediate Follow-up
Participants are monitored for chorioamniotic membrane separation and other complications up to hospital discharge
Extended Follow-up
Investigators collect follow-up data on the health of the participant and the babies until the babies turn one month old
Treatment Details
Interventions
- Fetoscopic Laser Photocoagulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor