Spravato

Status Asthmaticus, Chronic Pain, Depression + 3 more
Treatment
9 FDA approvals
20 Active Studies for Spravato

What is Spravato

EsketamineThe Generic name of this drug
Treatment SummaryMajor depressive disorder (MDD) is a common health condition that can lead to disability or even suicide. In 2019, the FDA approved a new nasal spray drug called Spravato (also known as Esketamine) to help people with MDD who have not responded to other treatments. This is the first time Esketamine has been approved by the FDA. Esketamine is a form of Ketamine, which was approved by the FDA in 1970. It is believed that Esketamine may be an effective treatment for MDD due to its easy administration and fast onset of action, compared to other antidepressant medications which may take weeks to
Spravatois the brand name
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Spravato Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spravato
Esketamine
2019
1

Approved as Treatment by the FDA

Esketamine, also called Spravato, is approved by the FDA for 9 uses including Pain and Intubation .
Pain
Intubation
Major depressive disorder, recurrent episode
Used to treat Major depressive disorder, recurrent episode in combination with null
Status Asthmaticus
Muscle Relaxation
Chronic Pain
General Anesthesia
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with null
Depression
Used in combination with Fluoxetine for Major Depressive Disorder (MDD)

Effectiveness

How Spravato Affects PatientsEsketamine is a drug that can cause drowsiness, dizziness, and tiredness. It also has a calming and antidepressant effect. Short-term use of esketamine may lead to trouble concentrating and slower reactions. It has been studied to evaluate its effect on driving ability, and no major difference between those taking esketamine and those taking a placebo was found. Esketamine can increase heart rate, but it is not known to cause long-term heart rhythm issues. Also, it may increase blood pressure, but this effect goes away after about 4 hours. In studies, people taking esketamine had
How Spravato works in the bodyEsketamine works by blocking the NMDA receptor, which is a type of glutamate receptor. This helps decrease nerve firing and can be used to treat depression. It is not yet known exactly how esketamine works, but its main metabolite has a similar effect, though with a weaker affinity.

When to interrupt dosage

The suggested dosage of Spravato is contingent upon the recognized ailment, including General Anesthesia, Status Asthmaticus and Muscle Relaxation. The measure of dosage changes as per the technique of administration (e.g. Solution - Nasal or Solution) tabulated in the table beneath.
Condition
Dosage
Administration
Status Asthmaticus
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,
Chronic Pain
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,
Depression
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,
General Anesthesia
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,
Muscle Relaxation
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,
Unipolar Depression
280.0 mg/mL, , 28.0 mg, 28.0 mg/pump actuation
Solution - Nasal, Solution, Nasal,

Warnings

Spravato Contraindications
Condition
Risk Level
Notes
Aneurysm
Do Not Combine
Stroke
Do Not Combine
Arteriovenous Malformations
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Esketamine may interact with Pulse Frequency
There are 20 known major drug interactions with Spravato.
Common Spravato Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Esketamine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Esketamine.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Esketamine.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Esketamine.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Esketamine.
Spravato Toxicity & Overdose RiskThe toxic dose of ketamine hydrochloride for rats is 447mg/kg. People who take ketamine may experience side effects such as nausea, kidney issues, heart problems, and nerve damage. Prolonged use has been linked to physical dependence and withdrawal symptoms, such as cravings, fatigue, poor appetite, and anxiety. It is also known to cause tolerance, meaning increasingly larger doses are needed to experience the same effects. Pregnant women should avoid taking ketamine as it could harm the fetus, and breastfeeding mothers should also avoid it due to the risk of neurotoxicity to the infant.
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Spravato Novel Uses: Which Conditions Have a Clinical Trial Featuring Spravato?

228 active clinical trials are currently assessing the efficacy of Spravato in relieving Status Asthmaticus, Intubations and facilitating General Anesthesia.
Condition
Clinical Trials
Trial Phases
Depression
196 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Status Asthmaticus
1 Actively Recruiting
Phase 2
Chronic Pain
144 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Muscle Relaxation
0 Actively Recruiting
General Anesthesia
0 Actively Recruiting
Unipolar Depression
52 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 2, Phase 1

Spravato Reviews: What are patients saying about Spravato?

5Patient Review
3/11/2022
Spravato for Additional Medications to Treat Depression
Sprovato has been a life-changing medication for me. I've gone from being severely suicidal and self-harming to truly happy. It's helped me be a better mom and wife. My psychiatrist says this is the happiest he's seen me in five years, even though there are some side effects like disassociation.
5Patient Review
7/27/2020
Spravato for Additional Medications to Treat Depression
Spravato was the first and only treatment that helped me achieve remission from my depression. I had been struggling with it for over three decades, and neither medication nor therapy were able to give me any relief. Spravato has truly been a life-saver.
5Patient Review
4/30/2021
Spravato for Additional Medications to Treat Depression
I had been struggling with depression for 25 years when I finally found a nurse practitioner who uses Spravato in their clinic. This drug completely changed my life for the better and helped me become the person I used to be before depression took over.
5Patient Review
8/3/2020
Spravato for Additional Medications to Treat Depression
This medication has been a game-changer for me. I'm finally able to live my life without PPHN constantly looming over me.
4.7Patient Review
6/5/2021
Spravato for Additional Medications to Treat Depression
This treatment completely changed my life for the better after years of depression. I finally feel like I have a reason to live again.
View All Reviews
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Patient Q&A Section about spravato

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Spravato a psychedelic?

"Industry experts say that of all the psychedelic treatments, Compass Pathways Plc is the furthest along."

Answered by AI

Is Spravato a narcotic?

"Will Spravato be a controlled substance in the United States?

Yes, Spravato (esketamine) is classified as a Schedule III controlled substance in the United States. Spravato is a rapid-acting nasal spray used in combination with an oral antidepressant to treat adults with treatment-resistant depression."

Answered by AI

What is Spravato used for?

"The U.S. Food and Drug Administration today approved Spravato (esketamine) nasal spray to be used in conjunction with an oral antidepressant for the treatment of depression in adults who have tried other antidepressant medicines but have not benefited from them (treatment-resistant depression)."

Answered by AI

How do you qualify for Spravato?

"SPRAVATO® must only be dispensed and administered in certified healthcare settings. Patients being treated in outpatient settings (e.g. medical offices and clinics) must be enrolled in the program."

Answered by AI

How does Spravato make you feel?

"Spravato can cause you to feel sleepy, anxious, or disconnected from yourself and your thoughts. In studies, feeling disconnected from yourself was the most common side effect, and feeling sleepy was one of the most common side effects."

Answered by AI

Clinical Trials for Spravato

Have you considered Spravato clinical trials? We made a collection of clinical trials featuring Spravato, we think they might fit your search criteria.
Have you considered Spravato clinical trials? We made a collection of clinical trials featuring Spravato, we think they might fit your search criteria.
Have you considered Spravato clinical trials? We made a collection of clinical trials featuring Spravato, we think they might fit your search criteria.
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