Solifenacin Succinate

Enlarged Prostate, Overactive Bladder Syndrome, moderate to severe symptoms + 2 more

Treatment

2 FDA approvals

20 Active Studies for Solifenacin Succinate

Treatment for

Enlarged Prostate

What is Solifenacin Succinate

SolifenacinThe Generic name of this drug

Treatment SummarySolifenacin is a medication used to treat an overactive bladder with urinary incontinence, urgency, and frequency. It is taken once a day and was approved by the FDA in 2004.

VESIcareis the brand name

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Solifenacin Succinate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

VESIcare

Solifenacin

2005

Approved as Treatment by the FDA

Solifenacin, commonly known as VESIcare, is approved by the FDA for 2 uses which include Overactive Bladder Syndrome (OABS) and Overactive Bladder Syndrome .

Overactive Bladder Syndrome (OABS)

Overactive Bladder Syndrome

Effectiveness

How Solifenacin Succinate Affects PatientsSolifenacin is a medication used to treat an overactive bladder. It works by blocking certain receptors in the bladder. It is normally taken once per day and may have long-lasting effects. Patients should be aware of the risk of potentially serious allergic reactions like angioedema and anaphylaxis when taking solifenacin.

How Solifenacin Succinate works in the bodySolifenacin is a drug that blocks the receptors in the bladder that cause muscle contractions. It works by stopping 80% of the receptors from sending signals to the detrusor muscle and 20% from sending signals to the smooth muscle. This prevents the muscles from contracting, reducing bladder discomfort.

When to interrupt dosage

The suggested dose of Solifenacin Succinate is determined by the diagnosed condition, including tamsulosin, Enlarged Prostate and Overactive Bladder Syndrome. The dosage amount is contingent upon the administration technique delineated in the table below.

Condition

Dosage

Administration

Enlarged Prostate

10.0 mg, , 5.0 mg, 1.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension

Overactive Bladder Syndrome

10.0 mg, , 5.0 mg, 1.0 mg/mL

moderate to severe symptoms

10.0 mg, , 5.0 mg, 1.0 mg/mL

inadequate response to monotherapy

10.0 mg, , 5.0 mg, 1.0 mg/mL

tamsulosin

10.0 mg, , 5.0 mg, 1.0 mg/mL

Warnings

Solifenacin Succinate Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Solifenacin may interact with Pulse Frequency

Gastric Retention

Do Not Combine

Urinary Retention

Do Not Combine

uncontrolled narrow-angle glaucoma

Do Not Combine

There are 20 known major drug interactions with Solifenacin Succinate.

Common Solifenacin Succinate Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Solifenacin is combined with Aclidinium.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Solifenacin.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Solifenacin.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Solifenacin.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Solifenacin is combined with Cimetropium.

Solifenacin Succinate Toxicity & Overdose RiskThe exact level of toxicity for solifenacin has not yet been established. Signs of overdose include severe dizziness, confusion, and loss of consciousness. Treatments include flushing the stomach and providing supportive care. Patients should also be monitored using an electrocardiogram (ECG).

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Solifenacin Succinate Novel Uses: Which Conditions Have a Clinical Trial Featuring Solifenacin Succinate?

53 active trials are in progress to assess the potential of Solifenacin Succinate to address inadequate response to monotherapy, tamsulosin and Enlarged Prostate conditions.

Condition

Clinical Trials

Trial Phases

inadequate response to monotherapy

0 Actively Recruiting

Overactive Bladder Syndrome

36 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

Enlarged Prostate

21 Actively Recruiting

Not Applicable, Phase 4, Phase 2

tamsulosin

0 Actively Recruiting

moderate to severe symptoms

0 Actively Recruiting

Solifenacin Succinate Reviews: What are patients saying about Solifenacin Succinate?

5Patient Review

4/17/2009

Solifenacin Succinate for Needing to Urinate Immediately

I had been taking detrusitol, but it wasn't helping my OAB at all. My urologist suggested an oxybutinin patch, which I tried for a month, but I was still having urgent problems (dashing to the toilet, sometimes every hour or less). Then my GP prescribed solifenacin succinate and there was an immediate improvement. I can now last 3-4 hours, which has dramatically improved my quality of life. This is after only 2 weeks and hopefully it will only get better from here.

4.7Patient Review

2/27/2013

Solifenacin Succinate for Frequent Urination

I've been on this medication for a little while now and it seems to be helping.

3.7Patient Review

10/21/2019

Solifenacin Succinate for Overactive Bladder

I've been taking this medication for two months and, unfortunately, have started to experience some negative side effects. These include headaches, blurry vision, constipation, and difficulty urinating. I'm seeing my doctor tomorrow to discuss whether or not I should continue taking this medication.

3Patient Review

6/5/2016

Solifenacin Succinate for Frequent Urination

Vesicare has helped me to reduce the frequency of my trips to the bathroom. I used to go every hour, and now I can go for a couple hours without having to go.

2.3Patient Review

7/16/2013

Solifenacin Succinate for Overactive Bladder

I have MS and this treatment didn't help me very much, if at all.

View All Reviews

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Patient Q&A Section about solifenacin succinate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drugs should not be taken with solifenacin?

"Other drugs that may interact with this medication include pramlintide, potassium tablets/capsules. Medications that can affect the removal of solifenacin from your body, which may in turn affect how solifenacin works, include certain azole antifungals (such as itraconazole, ketoconazole), mifepristone, and others."

Answered by AI

When should I take solifenacin succinate?

"Solifenacin tablets are typically taken just once a day, with or without food. The suspension form of solifenacin (VESIcare LS) is also typically taken once a day. To help you remember to take your medication, try to take it at the same time each day."

Answered by AI

Is it best to take solifenacin at night or in the morning?

"Nighttime dosing with solifenacin would be more effective at improving nighttime symptoms like nocturia, since peak plasma concentrations are reached 3-8 hours after it's been absorbed from the gut."

Answered by AI

What are the side effects of taking solifenacin?

"The following are symptoms of a bladder infection: bladder pain, bloody or cloudy urine, decrease in the frequency of urination, decrease in urine volume, difficult, burning, or painful urination, dry eyes, frequent urge to urinate, pounding in the ears."

Answered by AI

Clinical Trials for Solifenacin Succinate

Have you considered Solifenacin Succinate clinical trials? We made a collection of clinical trials featuring Solifenacin Succinate, we think they might fit your search criteria.

Explore trials for Solifenacin Succinate

Have you considered Solifenacin Succinate clinical trials? We made a collection of clinical trials featuring Solifenacin Succinate, we think they might fit your search criteria.