Sirolimus

corticosteroid therapy, Kidney Transplant, Lymphangioleiomyomatosis + 5 more
Treatment
3 FDA approvals
20 Active Studies for Sirolimus

What is Sirolimus

SirolimusThe Generic name of this drug
Treatment SummaryTemsirolimus (brand name Torisel) is a medication used to treat renal cell carcinoma, a type of kidney cancer. It was approved by the FDA and EMEA in 2007. It is a derivative of sirolimus, a drug used to suppress the immune system.
Rapamuneis the brand name
image of different drug pills on a surface
Sirolimus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rapamune
Sirolimus
1999
43

Approved as Treatment by the FDA

Sirolimus, also known as Rapamune, is approved by the FDA for 3 uses such as corticosteroid therapy and Organ Transplantation .
corticosteroid therapy
Used to treat corticosteroid therapy in combination with Cyclosporine
Organ Transplantation
Used to treat Transplanted Organ Rejection in combination with Cyclosporine
Kidney Transplant
Used to treat Kidney Transplantation in combination with Cyclosporine

Effectiveness

How Sirolimus works in the bodyTemsirolimus is a drug that stops a cell from dividing by targeting mTOR, a protein that controls cell division. When mTOR is blocked, the cell is unable to progress through the cell cycle and is instead forced to remain in a resting state. This drug also reduces the levels of two proteins, HIF-1 and HIF-2 alpha, which are linked to tumor growth. It also decreases the amount of a protein called vascular endothelial growth factor that can help tumors spread.

When to interrupt dosage

The recommended dose of Sirolimus is contingent upon the perceived condition. The amount of dosage fluctuates as per the delivery approach set out in the table beneath.
Condition
Dosage
Administration
Tuberous Sclerosis
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Renal Angiomyolipomas
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Chronic Graft Versus Host Disease
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Organ Transplantation
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
corticosteroid therapy
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Kidney Transplant
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Lymphangioleiomyomatosis
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel
Chordoma
, 2.0 mg, 1.0 mg, 0.5 mg, 5.0 mg, 1.0 mg/mL, 5.0 mg/mL, 0.002 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, powder, lyophilized, for suspension - Intravenous, Intravenous, Injection, powder, lyophilized, for suspension, Gel - Topical, Topical, Gel

Warnings

Sirolimus has a single contraindication and should not be utilized when encountering any of the conditions noted in the following table.Sirolimus Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Sirolimus may interact with Pulse Frequency
There are 20 known major drug interactions with Sirolimus.
Common Sirolimus Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Acteoside.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Sirolimus is combined with Antilymphocyte immunoglobulin (horse).
Sirolimus Toxicity & Overdose RiskTemsirolimus has been tested on cancer patients in early clinical trials with doses up to 220 mg/m2. Taking doses higher than 25 mg can increase the risk of potentially serious side effects, such as blood clots, punctured intestines, lung disease, seizures, and mental health issues.
image of a doctor in a lab doing drug, clinical research

Sirolimus Novel Uses: Which Conditions Have a Clinical Trial Featuring Sirolimus?

Fifteen active trials are actively investigating the potential of Sirolimus to treat Advanced Renal Cell Carcinoma (aRCC).
Condition
Clinical Trials
Trial Phases
Kidney Transplant
35 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 4, Phase 3
Organ Transplantation
0 Actively Recruiting
corticosteroid therapy
0 Actively Recruiting
Lymphangioleiomyomatosis
4 Actively Recruiting
Phase 1, Phase 2, Phase 3
Chordoma
0 Actively Recruiting
Chronic Graft Versus Host Disease
25 Actively Recruiting
Phase 4, Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1
Renal Angiomyolipomas
0 Actively Recruiting
Tuberous Sclerosis
6 Actively Recruiting
Phase 3, Phase 4, Phase 2, Phase 1

Sirolimus Reviews: What are patients saying about Sirolimus?

4Patient Review
11/10/2007
Sirolimus for Prevention of Cardiac Transplant Rejection
I've had a heart transplant five years ago and have been using this medication ever since to prevent rejection. So far, it's working great!
4Patient Review
4/7/2009
Sirolimus for Prevent Kidney Transplant Rejection
I've had a new kidney for seven years now and have only had a few health issues since, none of which were serious.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sirolimus

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sirolimus a steroid?

"The usage of rapamycin as a means of reducing the amount of steroids needed to treat dermatomyositis."

Answered by AI

Is sirolimus chemotherapy?

"They are called "antineoplastic" drugs.

The use of sirolimus as an antineoplastic drug is based on the rationale that it prevents tumor cells from dividing, which in turn inhibits their growth or causes them to die."

Answered by AI

What is the drug sirolimus used for?

"Sirolimus is used in combination with other medications to prevent organ rejection in transplant patients. It is classified as an immunosuppressive agent. When a patient receives a transplanted organ, the body's white blood cells try to remove the transplanted organ."

Answered by AI

What are side effects of taking sirolimus?

"The most common side effects of this drug are swelling in the limbs, high levels of triglycerides in the blood, high blood pressure, high cholesterol, increased creatinine levels, constipation, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and low platelet count."

Answered by AI

Clinical Trials for Sirolimus

Have you considered Sirolimus clinical trials? We made a collection of clinical trials featuring Sirolimus, we think they might fit your search criteria.
Have you considered Sirolimus clinical trials? We made a collection of clinical trials featuring Sirolimus, we think they might fit your search criteria.
Have you considered Sirolimus clinical trials? We made a collection of clinical trials featuring Sirolimus, we think they might fit your search criteria.
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