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Pleasant Odors for Craving (OdorCrave Trial)

N/A
Recruiting
Led By Michael A Sayette, PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Pass an MRI safety screening and along these lines will need to be 250lbs or less to safely enter the MRI
Aged 18-49
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 1 month of enrollment; during the fmri scan
Awards & highlights

OdorCrave Trial Summary

This trial will study the effects of pleasant smells on cigarette cravings in smokers. They will use fMRI to look at the brain states of participants and study how pleasant smells affect them.

Who is the study for?
This trial is for right-handed, English-speaking adults aged 18-49 who smoke cigarettes daily (10-30 per day) or nondaily. They must weigh less than 250lbs to fit in an MRI machine safely, have a working smartphone, and an intact sense of smell. Smokers with extreme habits or other drug dependencies besides nicotine or caffeine are excluded.Check my eligibility
What is being tested?
The study tests if pleasant smells can reduce cigarette cravings more effectively than neutral odors. It involves three visits: baseline assessments, fMRI scans while exposed to smoking cues and either pleasant/neutral smells, and behavioral tests on craving responses. Participants will also track their cravings for a week using their smartphones.See study design
What are the potential side effects?
There may be minimal side effects related to the exposure to different odors; however, participants could experience discomfort from the MRI procedure or anxiety from craving assessments.

OdorCrave Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I weigh 250lbs or less and can safely undergo an MRI.
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I am between 18 and 49 years old.

OdorCrave Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 1 month of enrollment; immediately before and after administration of the olfactory cue
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 1 month of enrollment; immediately before and after administration of the olfactory cue for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Craving Observed During Pleasant Compared to Neutral OC Exposure Assessments, Controlling for Pre-OC Craving Ratings
Disruption of the Craving Brain State by the Pleasant, Compared to the Neutral, Olfactory Cue
Secondary outcome measures
Change in Craving from Peak Craving to the Craving Observed During Pleasant, Compared to Neutral, Olfactory Cues as Measured by a Pressure-Sensitive Squeeze Device
Mediating Role of the Emotional Response to the Pleasant Olfactory Cue, as Indexed by the Facial Action Coding System, on the Impact of Pleasant Olfactory Cues on Self-Reported Craving
Strength of the Cognitive-Associated Neural Fingerprint Induced During the Pleasant Compared to Neutral Olfactory Cue

OdorCrave Trial Design

2Treatment groups
Experimental Treatment
Group I: Pleasant OdorExperimental Treatment1 Intervention
Participants in this condition will sniff the olfactory cue they rate as both pleasant (>5 on the 1-9 scale) and the most intense following cigarette cue exposure. If this odor is the same as their self-reported preferred e-cigarette flavor, we will choose the next most intense odor out of the odors rated as pleasant.
Group II: Odor BlankExperimental Treatment1 Intervention
Participants in this condition will sniff a neutral olfactory cue (odor blank) following cigarette cue exposure.

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,716 Previous Clinical Trials
16,346,204 Total Patients Enrolled
1 Trials studying Craving
National Center for Complementary and Integrative Health (NCCIH)NIH
829 Previous Clinical Trials
668,679 Total Patients Enrolled
Michael A Sayette, PhDPrincipal InvestigatorThe University of Pittsburgh

Media Library

Odor Blank Clinical Trial Eligibility Overview. Trial Name: NCT04902469 — N/A
Craving Research Study Groups: Pleasant Odor, Odor Blank
Craving Clinical Trial 2023: Odor Blank Highlights & Side Effects. Trial Name: NCT04902469 — N/A
Odor Blank 2023 Treatment Timeline for Medical Study. Trial Name: NCT04902469 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age criterion of 75 years or younger applicable to participants in this experiment?

"As per the prerequisites for participation in this clinical trial, only patients between 18 and 49 years old can be enrolled."

Answered by AI

What qualifications are necessary to be a part of this research project?

"This investigation is seeking 250 contributors aged between 18 and 49, yearning for nicotine. Essential qualifications include being right-handed, abstaining from all drugs apart from caffeine and tobacco, falling into one of two categories (daily or non-daily) as confirmed by a verbal report and carbon monoxide reading; daily smokers must consume 10 to 30 cigarettes per day in the last 12 months whereas nondaily smokers should not exceed 20 cigs during 1 to 14 days within the same period - an intact sense of smell is also expected. Additionally, participants need access to a compatible smartphone for completing ecological momentary assessment tasks related to this research endeavour."

Answered by AI

What is the size of the participant pool for this research study?

"Affirmative, the information on clinicaltrials.gov confirms that this experiment is actively accepting participants. The trial was first advertised on December 1st 2021 and has since been modified as recently as April 29th 2022. There are 250 spots open across one site location."

Answered by AI
~83 spots leftby Jun 2025