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What is Seroquel Xr
QuetiapineThe Generic name of this drug
Treatment SummaryQuetiapine is an antipsychotic medication that was approved by the FDA in 1997. It is used to treat schizophrenia, major depression, and bipolar disorder. Quetiapine is effective and has few side effects when taken for long periods of time. It is a good option for people who cannot tolerate other antipsychotic medications, such as clozapine and olanzapine.
Seroquelis the brand name
Seroquel Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Seroquel
Quetiapine
1997
700
Approved as Treatment by the FDA
Quetiapine, also known as Seroquel, is approved by the FDA for 3 uses which include Bipolar 1 Disorder and Bipolar Disorder .Bipolar 1 Disorder
Used in combination with other therapies
Bipolar Disorder
Used in combination with other therapies
Depression
Effectiveness
How Seroquel Xr Affects PatientsQuetiapine works by affecting certain brain chemicals (like serotonin and dopamine) to improve the symptoms of schizophrenia, depression, and bipolar disorder. However, this drug has been linked to suicidal thoughts or behavior in children and adolescents and should not be given to those under 10 years old. It is important to be aware of any signs of suicidal behavior when taking this drug. Also, it is not recommended for treating psychosis related to dementia in elderly patients as it can increase their risk of death.
How Seroquel Xr works in the bodyQuetiapine targets several receptors in the body to treat different conditions. For schizophrenia, it inhibits dopamine and serotonin receptors. In depression, it binds to the norepinephrine transporter. Other effects, such as drowsiness, low blood pressure, and dry mouth are caused by blocking H1, adrenergic alpha-1, and muscarinic M1 receptors respectively.
When to interrupt dosage
The recommended dosage of Seroquel Xr is contingent upon the determined condition, such as Mental Depression, Bipolar Disorder and Acute Coryza. The measure of dosage changes, depending on the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Parkinson's Disease
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Schizophrenia
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Schizophrenia
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Acute Coryza
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Bipolar Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Bipolar Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Behcet Syndrome
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Depression
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Post Traumatic Stress Disorder
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Mental Depression
, 50.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg, 25.0 mg, 550.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
There are 20 known major drug interactions with Seroquel Xr.Common Seroquel Xr Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Quetiapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Quetiapine is combined with Aclidinium.
Alfuzosin
Major
Quetiapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Quetiapine may increase the antipsychotic activities of Amisulpride.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Quetiapine is combined with Anagrelide.
Seroquel Xr Toxicity & Overdose RiskThe lowest toxic dose of quetiapine in rats is 2000 mg/kg. Signs of an overdose include drowsiness, rapid heart rate, and low blood pressure. In clinical trials, people have survived overdoses of up to 30 grams of quetiapine, although one death was reported after an overdose of 13.6 grams. To treat an overdose, medical professionals may provide oxygen, perform intubation if necessary, and use activated charcoal and a laxative. It's important to monitor the heart rate after an overdose since there have been reports of a prolonged heartbeat. Additionally, drugs like disopyramide, proc
Seroquel Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Seroquel Xr?
At present, 705 active clinical trials are investigating the potential of Seroquel XR to provide relief from Depression, Schizophrenia and Bipolar Disorder.Condition
Clinical Trials
Trial Phases
Schizophrenia
106 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Bipolar Disorder
0 Actively Recruiting
Post Traumatic Stress Disorder
235 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Generalized Anxiety Disorder
2 Actively Recruiting
Not Applicable
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Depression
195 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Mental Depression
1 Actively Recruiting
Not Applicable
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Bipolar Disorder
0 Actively Recruiting
Schizophrenia
33 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Seroquel Xr Reviews: What are patients saying about Seroquel Xr?
5Patient Review
12/18/2021 I took Seroquel XR in conjunction with Amitriptyline for approximately 20 years to address my depression. This combination worked well for me until last year when my nurse practitioner increased my dosage of Seroquel XR to 400 mg and took me off amitriptyline. I've had great results with this new treatment plan, except for issues with night sweats and constipation. For the latter problem, I take magnesium supplements.
5Patient Review
12/12/2021 This medication has been a life-changer for me. It helps with my anxiety without making me feel sedated or dumb. I feel calm and my social anxiety goes away. It's a miracle drug and, in my opinion, one of the best medications out there.
4.3Patient Review
5/25/2017 I'm pretty content with this drug. No real negative side effects that I've notices, though it doesn't quite treat my depression entirely. Additionally, it can make me a bit groggy in the morning if I haven't had enough sleep, but that's manageable. All things considered, I would recommend this to others in a similar situation to myself.
4.3Patient Review
3/27/2016 This medication has been great for me. I only had one depressive episode in the year that I've been taking it, and was able to work through it without help from my psychiatrist. Additionally, there have been no side effects like weight gain or sedation.
4Patient Review
5/28/2016 I took this medication for seven years before quitting cold turkey. Unfortunately, that led to some pretty severe manic episodes that landed me in jail. Since then, I've been more careful about monitoring my mental health and taking other medications as needed. If you're considering stopping this medication, please be very cautious and aware of potential changes in your behavior.
Patient Q&A Section about seroquel xr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does Seroquel XR last?
"Quetiapine's peak plasma concentration is often reached in 6 hours, with a mean terminal half-life of 7 hours."
Answered by AI
What is Seroquel XR used for?
"This medication is used to treat certain mental/mood disorders such as schizophrenia, bipolar disorder, and sudden episodes of depression associated with bipolar disorder. It is also used with other medications to treat depression. Quetiapine is known as an anti-psychotic drug (atypical type)."
Answered by AI
How does Seroquel XR make you feel?
"You should not breastfeed while taking SEROQUEL XR, as it may cause drowsiness, dry mouth, constipation, dizziness, increased appetite, upset stomach, weight gain, fatigue, difficulty moving, and disturbance in speech or language, as well as a stuffy nose."
Answered by AI
What is the difference between Seroquel Seroquel and XR?
"Seroquel is available in tablet form (25, 100, 150, 200 and 300 mg) and as a prolonged-release tablet (50, 150, 200, 300 and 400 mg). The active ingredient in Seroquel is slowly released from the tablet over a period of a few hours."
Answered by AI
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