Sensorcaine

Stevens-Johnson Syndrome, Ophthalmia, Sympathetic, Berylliosis + 71 more

Treatment

16 FDA approvals

20 Active Studies for Sensorcaine

Treatment for

Stevens-Johnson Syndrome

What is Sensorcaine

Bupivacaine

The Generic name of this drug

Treatment Summary

Bupivacaine is a type of pain reliever used to dull sensations of pain in a specific area.

Bupivacaine Hydrochloride and Epinephrine

is the brand name

Sensorcaine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bupivacaine Hydrochloride and Epinephrine

Bupivacaine

1988

197

Approved as Treatment by the FDA

Bupivacaine, also known as Bupivacaine Hydrochloride and Epinephrine, is approved by the FDA for 16 uses including Alopecia Areata and Inflammation .

Alopecia Areata

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of lichen simplex in combination with Lidocaine

Psoriasis

Used to treat Psoriatic plaque in combination with Lidocaine

Inflammation

Used to treat inflammatory lesions of granuloma annulare in combination with Lidocaine

Nerve Block

Discoid Lupus Erythematosus (DLE)

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Flatfoot

Used to treat inflammatory lesions of lichen planus in combination with Lidocaine

Tendon structure

Used to treat cystic tumors of tendon in combination with Lidocaine

Alopecia Areata (AA)

Used to treat Alopecia Areata (AA) in combination with Lidocaine

Aponeurosis structure

Used to treat cystic tumors of aponeurosis in combination with Lidocaine

General Anesthesia

Keloids Scars

Used to treat Keloids Scars in combination with Lidocaine

Psoriatic plaque

Used to treat Psoriatic plaque in combination with Lidocaine

Lupus Erythematosus, Discoid

Used to treat Discoid Lupus Erythematosus (DLE) in combination with Lidocaine

Local Anaesthesia therapy

Necrobiosis Lipoidica

Used to treat Necrobiosis lipoidica diabeticorum in combination with Lidocaine

Effectiveness

How Sensorcaine Affects Patients

Bupivacaine is a common local anesthetic used in surgeries. It can help reduce pain for up to 20 hours after surgery. Compared to other local anesthetics, bupivacaine has a long duration of action. However, it can also be toxic to the heart when taken in large doses, so other medications like ropivacaine and levobupivacaine are often used as alternatives. Taking bupivacaine can cause changes to the cardiovascular and nervous systems, including decreased blood pressure and cardiac conduction, and can even lead to cardiac arrest. Additionally, it may cause central nervous system stimulation

How Sensorcaine works in the body

Bupivacaine is an anesthetic that works by blocking nerve impulses from reaching the brain. It does this by blocking sodium ions from passing through the neuron’s pore, which prevents neurotransmission. Its effects are felt in order of pain, temperature, touch, proprioception, and then muscle tone. In addition to blocking nerve impulses, bupivacaine is also thought to reduce inflammation and fever by binding to receptors that reduce prostaglandin production.

When to interrupt dosage

The proposed measure of Sensorcaine is contingent upon the acknowledged condition, such as Idiopathic Nephrotic Syndrome, Lupus and Thyroiditis. The dose also fluctuates in accordance with the method of delivery indicated in the table below.

Condition

Dosage

Administration

Berylliosis

, 5.0 mg/mL, 7.5 mg/mL, 2.5 mg/mL, 1.25 mg/mL, 1.0 mg/mL, 2.5 mg, 5.0 mg, 7.5 mg, 13.3 mg/mL, 15.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 125.0 mg, 250.0 mg, 3.0 mg/mL, 1.0 mg/mg, 3.75 mg/mL, 9.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 26.6 mg/mL, 200.0 mg, 60.0 mg, 400.0 mg, 200.0 mg/mL, 30.0 mg/mL, 40.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 15.0 mg/mL, 660.0 mg/mL

, Injection, solution, Subcutaneous, Injection, solution - Subcutaneous, Epidural; Retrobulbar, Injection, solution - Epidural; Infiltration; Intracaudal, Injection, solution - Subarachnoid, Subarachnoid, Epidural; Infiltration; Intracaudal, Injection, solution - Epidural; Retrobulbar, Epidural, Injection, solution - Epidural, Perineural, Injection, solution - Perineural, Injection, solution - Epidural; Infiltration, Epidural; Infiltration, Infiltration, Injection, solution - Infiltration, Injection, solution - Epidural; Intracaudal, Epidural; Intracaudal, Kit, Infiltration; Perineural, Injection, solution - Infiltration; Perineural, Epidural; Infiltration; Intracaudal; Perineural, Epidural; Intracaudal; Perineural, Injection, solution - Epidural; Infiltration; Intracaudal; Perineural, Injection, solution - Epidural; Intracaudal; Perineural, Solution, Solution - Epidural; Infiltration, Intraspinal, Solution - Intraspinal, Solution - Epidural; Retrobulbar, Solution - Infiltration, Liquid, Liquid - Epidural; Retrobulbar, Liquid - Epidural; Infiltration, Liquid - Intraspinal, Liquid - Infiltration, Solution - Epidural; Infiltration; Intracaudal, Kit - Topical, Topical, Injection, suspension, liposomal, Injection, suspension, liposomal - Infiltration, Injection, solution - Intraspinal, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Dental; Infiltration, Dental; Infiltration, Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Kit - Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intravenous, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Epidural; Infiltration; Topical, Kit - Epidural; Infiltration; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Topical, Epidural; Parenteral, Injection, Injection - Epidural; Parenteral, Injection - Epidural; Parenteral; Retrobulbar, Spray, metered - Topical, Spray, metered, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Retrobulbar, Injection - Retrobulbar, Epidural; Parenteral; Retrobulbar, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Epidural; Infiltration; Parenteral, Injection - Epidural; Infiltration; Parenteral, Infiltration; Parenteral, Injection - Infiltration; Parenteral, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Parenteral, Injection - Parenteral, Kit - Epidural; Infiltration; Intracaudal; Perineural, Enteral; Epidural; Intracaudal, Injection, solution - Enteral; Epidural; Intracaudal, Injection - Subarachnoid, Injection - Epidural; Intracaudal; Perineural, Intravenous, Injection - Intravenous, Intra-articular; Intramuscular, Implant, Implant - Parenteral, Solution - Intralesional, Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Intralesional

Psoriasis

Psoriatic Arthritis

Red-Cell Aplasia, Pure

Arthritis, Gouty

General Anesthesia

Epidural Block

Anesthesia, Conduction

Idiopathic Nephrotic Syndrome

Inflammation

Analgesics

Multiple Sclerosis

Bullous dermatitis herpetiformis

Arthroscopy

Lupus

Anemia, Hemolytic

Lymphoma, Non-Hodgkin

Inflammation

Interscalene Nerve Block

Lupus erythematosus cell

Warnings

Sensorcaine has seven contraindications. It should not be taken if you are having any of the conditions detailed in the table below.

Sensorcaine Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

history of NSAID allergy

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Asthma

Do Not Combine

obstetrical paracervical block anesthesia

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Bupivacaine may interact with Pulse Frequency

There are 20 known major drug interactions with Sensorcaine.

Common Sensorcaine Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Bupivacaine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Bupivacaine.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Bupivacaine.

Azelastine

Major

Bupivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Bupivacaine.

Sensorcaine Toxicity & Overdose Risk

The average amount of bupivacaine that causes seizures in monkeys is 4.4mg/kg, with an average concentration of 4.5mcg/mL in their bloodstream. The most toxic dose for mice is 6-8mg/kg when given intravenously, and 38-54mg/kg when given subcutaneously. People who experience seizures from bupivacaine will quickly develop breathing problems and acidosis, so it is important to provide them with oxygen right away to prevent cardiac arrest.

image of a doctor in a lab doing drug, clinical research

Sensorcaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Sensorcaine?

288 active trials are examining the potential benefits of Sensorcaine in mitigating Ulcerative Colitis, Lupus and Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Lupus

65 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Labor Pain

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

General Anesthesia

1 Actively Recruiting

Phase 4

Regional Analgesia

0 Actively Recruiting

Hypersensitivity

0 Actively Recruiting

Local Analgesia

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Alopecia Areata

1 Actively Recruiting

Phase 1

Local Anaesthesia therapy

0 Actively Recruiting

Idiopathic Nephrotic Syndrome

0 Actively Recruiting

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Adrenal Insufficiency

0 Actively Recruiting

induction of Local Anaesthesia

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Open Abdominal Surgery

1 Actively Recruiting

Not Applicable

Multiple Sclerosis

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Tuberculosis, Pulmonary

0 Actively Recruiting

Patient Q&A Section about sensorcaine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Sensorcaine with epinephrine used for?

"It is used to numb an area before a procedure."

Answered by AI

How do you administer Sensorcaine?

"Sensorcaine injections are sterile solutions that contain a local anesthetic agent, bupivacaine HCl, with or without epinephrine. They are administered parenterally, meaning by injection."

Answered by AI

What is Sensorcaine used for?

"Sensorcaine (bupivacaine HCl) Injections numbs the area it is injected into. It is used as a local anesthetic for a spinal block."

Answered by AI

What is the difference between bupivacaine and Sensorcaine?

"Bupivacaine is a prescription medication that is used as a local anesthetic. It works by blocking the nerve impulses that send pain signals to your brain. Bupivacaine is available under different brand names, including Marcaine and Sensorcaine."

Answered by AI