Retrovir

perinatal HIV transmission, Antiretroviral Therapy, HIV + 1 more
Treatment
1 FDA approval
20 Active Studies for Retrovir

What is Retrovir

ZidovudineThe Generic name of this drug
Treatment SummaryAzidothymidine (AZT) is an anti-HIV medication that prevents the formation of necessary molecules needed to complete the replication of the virus. It is effective in improving the immunologic function of a patient, reversing some of the neurological dysfunction caused by HIV, and improving other clinical abnormalities associated with AIDS. The most common side effect of AZT is a decrease in bone marrow production, which can lead to anemia and leukopenia.
Retroviris the brand name
image of different drug pills on a surface
Retrovir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Retrovir
Zidovudine
1987
99

Approved as Treatment by the FDA

Zidovudine, commonly known as Retrovir, is approved by the FDA for 1 uses which include HIV .
HIV
Used to treat Human Immunodeficiency Virus (HIV) Infections in combination with Abacavir

Effectiveness

How Retrovir Affects PatientsZidovudine is a drug used to fight the Human Immunodeficiency Virus Type 1 (HIV-1) infection. It works by blocking the virus from reproducing, by competing with it for incorporation into viral DNA. This prevents the virus from creating and adding to its DNA, which stops it from growing and spreading.
How Retrovir works in the bodyZidovudine is a drug that works to stop HIV-1 from replicating. It does this by blocking the activity of the virus' reverse transcriptase, which is responsible for creating new copies of the virus. Zidovudine is a prodrug, meaning it must first be converted into an active form in the body before it can take effect. Once it is converted, it works to block the virus from making new copies by competing with the natural substrate and blocking the action of cellular DNA polymerase.

When to interrupt dosage

The suggested dosage of Retrovir is reliant upon the established condition, including perinatal HIV transmission, HIV Transmission and HIV. The amount likewise differs as per the technique of delivery (e.g. Injection, solution - Intravenous or Oral) featured in the table below.
Condition
Dosage
Administration
perinatal HIV transmission
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup, Syrup - Oral, Liquid, Intravenous, Liquid - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Solution, Tablet, coated, Tablet, coated - Oral
HIV
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup, Syrup - Oral, Liquid, Intravenous, Liquid - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Solution, Tablet, coated, Tablet, coated - Oral
HIV Transmission
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup, Syrup - Oral, Liquid, Intravenous, Liquid - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Solution, Tablet, coated, Tablet, coated - Oral
Antiretroviral Therapy
, 300.0 mg, 100.0 mg, 50.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup, Syrup - Oral, Liquid, Intravenous, Liquid - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Solution, Tablet, coated, Tablet, coated - Oral

Warnings

There are 20 known major drug interactions with Retrovir.
Common Retrovir Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Zidovudine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Zidovudine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Zidovudine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Zidovudine is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Zidovudine is combined with Aldosterone.
Retrovir Toxicity & Overdose RiskAn overdose of this medication may cause tiredness, headache, nausea, and vomiting. The lowest toxic dose for mice when taken orally is 3084 mg/kg.
image of a doctor in a lab doing drug, clinical research

Retrovir Novel Uses: Which Conditions Have a Clinical Trial Featuring Retrovir?

122 active clinical trials are currently assessing the potential of Retrovir to control HIV Transmission, Perinatal HIV Transmittal, and HIV-related conditions.
Condition
Clinical Trials
Trial Phases
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
perinatal HIV transmission
0 Actively Recruiting
HIV Transmission
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1

Retrovir Reviews: What are patients saying about Retrovir?

3Patient Review
2/1/2011
Retrovir for Osteoporosis
This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/1/2011
Retrovir for Osteoporosis
This drug is great. It really helped me.
3Patient Review
2/1/2011
Retrovir for Osteoporosis
This drug is great. I'm grateful for modern medicine.
3Patient Review
2/1/2011
Retrovir for Osteoporosis
This drug is great. It really helped me out.
3Patient Review
2/1/2011
Retrovir for Osteoporosis
This drug is effective. I'm grateful for modern medicine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about retrovir

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Retrovir?

"headache, nausea, vomiting, trouble sleeping, loss of appetite, and changes in the shape or location of body fat."

Answered by AI

Is Retrovir an antiviral?

"Retrovir can be used to combat HIV, and potentially prevent an infected mother from passing the virus on to her baby. It's important to note that this medicine is not a cure for HIV or AIDS."

Answered by AI

What is Retrovir used to treat?

"Retrovir is used to treat human immunodeficiency virus (HIV) infection. The active ingredient in Retrovir is zidovudine. Retrovir is a type of medicine known as an anti- retroviral. It belongs to a group of medicines called nucleoside analogue reverse transcriptase inhibitors (NRTIs)."

Answered by AI

What is the generic name of Retrovir?

"Brand Names: Retrovir

The generic name for Retrovir is Zidovudine, and it is taken orally."

Answered by AI

Clinical Trials for Retrovir

Have you considered Retrovir clinical trials? We made a collection of clinical trials featuring Retrovir, we think they might fit your search criteria.
Have you considered Retrovir clinical trials? We made a collection of clinical trials featuring Retrovir, we think they might fit your search criteria.
Have you considered Retrovir clinical trials? We made a collection of clinical trials featuring Retrovir, we think they might fit your search criteria.