Repaglinide

Physical Activity, Type 2 Diabetes, Diet
Treatment
3 FDA approvals
20 Active Studies for Repaglinide

What is Repaglinide

RepaglinideThe Generic name of this drug
Treatment SummaryRepaglinide is a medication used to treat non-insulin dependent diabetes mellitus. It is a short-acting insulin secretagogue which helps stimulate the pancreas to release insulin. Repaglinide works by lowering postprandial and fasting blood glucose levels and reducing the amount of glycosylated hemoglobin (HbA1c). It should only be taken with meals and skipped when meals are missed. It may cause a slight increase in weight, but the risk of this is lower than other diabetes medications. Repaglinide is broken down in the liver and mostly eliminated in feces, with a small amount
Prandinis the brand name
image of different drug pills on a surface
Repaglinide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prandin
Repaglinide
2000
59

Approved as Treatment by the FDA

Repaglinide, otherwise called Prandin, is approved by the FDA for 3 uses which include Type 2 Diabetes and Physical Activity .
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Physical Activity
Used to treat Exercise in combination with Metformin
Diet
Used to treat Diet in combination with Metformin

Effectiveness

How Repaglinide Affects PatientsInsulin release from the pancreas is partially determined by the electric charge of the cell membrane. When the amount of glucose outside the cell is low, the electric charge increases and insulin is released. The drug repaglinide helps to increase the amount of insulin released by blocking the electric charge when glucose levels are high. This causes the cell to open and release insulin granules.
How Repaglinide works in the bodyRepaglinide helps to lower blood sugar levels after meals, but not while fasting. It works by making the cells in the pancreas more responsive to glucose and releasing more insulin. These effects are strongest when blood sugar levels are between 3-10 mmol/L and have little effect when blood sugar is higher than 15 mmol/L. Repaglinide has no effect on other types of cells, like muscle or thyroid cells. It takes around a month of treatment to reduce fasting blood sugar levels.

When to interrupt dosage

The prescribed dosage of Repaglinide hinges upon the determined affliction, including Diet, Physical Activity and Type 2 Diabetes. The quantity of dosage is contingent upon the method of delivery (e.g. Tablet or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Physical Activity
, 0.5 mg, 2.0 mg, 1.0 mg, 2.0 mg/mg, 1.0 mg/mg
Tablet, , Oral, Tablet - Oral, Pill - Oral, Pill
Diet
, 0.5 mg, 2.0 mg, 1.0 mg, 2.0 mg/mg, 1.0 mg/mg
Tablet, , Oral, Tablet - Oral, Pill - Oral, Pill
Type 2 Diabetes
, 0.5 mg, 2.0 mg, 1.0 mg, 2.0 mg/mg, 1.0 mg/mg
Tablet, , Oral, Tablet - Oral, Pill - Oral, Pill

Warnings

There are 20 known major drug interactions with Repaglinide.
Common Repaglinide Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Repaglinide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Repaglinide.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Repaglinide.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Repaglinide.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Repaglinide.
Repaglinide Toxicity & Overdose RiskThe toxic dose of this drug in rats is greater than 1g/kg.
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Repaglinide Novel Uses: Which Conditions Have a Clinical Trial Featuring Repaglinide?

196 active clinical trials are being conducted to assess the feasibility of Repaglinide in treating Diet, Physical Activity and Type 2 Diabetes.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1

Repaglinide Reviews: What are patients saying about Repaglinide?

5Patient Review
6/19/2010
Repaglinide for Type 2 Diabetes Mellitus
I've been using repaglinide for 14 years and it's always done a great job of keeping my glucose levels in check. Only recently have my readings gone up slowly, so my doctor is thinking about changing my medication. It's easy to use and remember to take, which are both big pluses.
5Patient Review
1/17/2021
Repaglinide for Type 2 Diabetes Mellitus
This medication is best taken in small doses (0.5 mg) to avoid hypoglycemia events. I recommend taking it with each meal, 3 times a day. It takes about 30 minutes for the pill to take effect.
4.7Patient Review
4/19/2021
Repaglinide for Type 2 Diabetes Mellitus
I was diagnosed with type 2 diabetes five years ago and have been taking metformin since then. No problems until my doctor recently put me on Repaglinide, which has caused weight gain as a side effect.
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Patient Q&A Section about repaglinide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is repaglinide?

"Repaglinide is a drug used in the treatment of diabetes mellitus type 2. It belongs to a class of antihyperglycemic agents known as meglitinides, along with nateglinide. Meglitinides work to reduce blood glucose levels by stimulating endogenous insulin production from the pancreas."

Answered by AI

What is the difference between metformin and repaglinide?

"Repaglinide increases the amount of insulin your pancreas releases into your bloodstream. Metformin decreases the amount of sugar absorbed from your stomach, reduces the release of stored sugar from your liver, and helps your body use sugar more effectively."

Answered by AI

What is the side effects of repaglinide?

"You may experience back, leg, or stomach pains, blistering or peeling skin, dark urine, difficulty breathing, general body swelling, fatigue, indigestion, or an itchy or rashy skin."

Answered by AI

When should you take repaglinide?

"This medicine is typically taken 15 minutes before a meal but can be taken up to 30 minutes before a meal."

Answered by AI

Clinical Trials for Repaglinide

Have you considered Repaglinide clinical trials? We made a collection of clinical trials featuring Repaglinide, we think they might fit your search criteria.
Have you considered Repaglinide clinical trials? We made a collection of clinical trials featuring Repaglinide, we think they might fit your search criteria.
Have you considered Repaglinide clinical trials? We made a collection of clinical trials featuring Repaglinide, we think they might fit your search criteria.
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