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What is Quinidine Gluconate
QuinidineThe Generic name of this drug
Treatment SummaryQuinidine is an active ingredient found in the bark of the Cinchona tree and other plants. It helps to relax the muscles of the heart and other parts of the body by blocking the flow of sodium and potassium across the cell membranes. Quinidine also prevents certain neurotransmitters from working properly, helping to reduce excitability.
Quinidine Gluconateis the brand name
Quinidine Gluconate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinidine Gluconate
Quinidine
1950
24
Approved as Treatment by the FDA
Quinidine, also known as Quinidine Gluconate, is approved by the FDA for 4 uses such as Ventricular Arrhythmia and Atrial Fibrillation .Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Atrial Fibrillation
Atrial Fibrillation or Flutter
Malaria
Effectiveness
How Quinidine Gluconate Affects PatientsQuinidine is a medication used to prevent or interrupt irregular heartbeats. It can lead to an increased heart rate in most patients, and makes the time between heartbeats longer (QT interval). This can cause a type of rapid irregular heartbeat called torsades de pointes. The risk of this happening is higher if the patient has low potassium, magnesium, or a slow heart rate. In some cases, quinidine can cause the opposite effect and make the heartbeat faster. This is more likely to happen if the patient has atrial flutter or fibrillation, or if they have a condition called sick sinus syndrome
How Quinidine Gluconate works in the bodyQuinidine works to reduce the risk of irregular heartbeats by influencing the flow of sodium and potassium in and out of the heart's cells. It does this by blocking the sodium channels, reducing the flow of potassium, and lengthening the action potential duration. It also has anti-malaria properties, which involve killing malaria parasites in the blood.
When to interrupt dosage
The amount of Quinidine Gluconate depends on the specified condition, including Ventricular Arrhythmia, reduce dextromethorphan metabolism and Atrial Fibrillation. The dosage is contingent upon the administration technique outlined in the table below.Condition
Dosage
Administration
Atrial Fibrillation or Flutter
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
reduce dextromethorphan metabolism
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Pseudobulbar Affect (PBA)
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Ventricular Arrhythmia
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Malaria
, 200.0 mg, 300.0 mg, 324.0 mg, 195.0 mg, 325.0 mg, 275.0 mg, 10.0 mg, 80.0 mg/mL, 100.0 mg, 190.0 mg/mL
Oral, Tablet, Tablet - Oral, , Tablet, extended release, Tablet, extended release - Oral, Intramuscular, Solution, Solution - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Intravenous, Solution - Intravenous
Warnings
Quinidine Gluconate has two contraindications, and its utilization should be avoided when encountering any of the conditions set out in the following table.Quinidine Gluconate ContraindicationsCondition
Risk Level
Notes
Thrombocytopenic Purpura
Do Not Combine
Myasthenia Gravis
Do Not Combine
Common Quinidine Gluconate Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Quinidine.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Quinidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Quinidine.
Acepromazine
Major
Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Quinidine Gluconate Toxicity & Overdose RiskTaking too much quinidine can be fatal, as seen in a toddler who died after ingesting 5 grams of the drug. A teenager survived after taking 8 grams. In some cases, quinidine can form a build-up in the stomach, increasing the toxic levels of the drug. Symptoms of a quinidine overdose may include an irregular heartbeat, low blood pressure, vomiting, diarrhea, ringing in the ears, vision problems, headache, confusion, and delirium. If a large amount has been taken, an endoscopy may be necessary.
Quinidine Gluconate Novel Uses: Which Conditions Have a Clinical Trial Featuring Quinidine Gluconate?
Currently, five investigations are underway to assess the efficacy of Quinidine Gluconate in providing relief for Atrial Fibrillation or Flutter, Atrial Fibrillation and Malaria.Condition
Clinical Trials
Trial Phases
reduce dextromethorphan metabolism
0 Actively Recruiting
Pseudobulbar Affect (PBA)
0 Actively Recruiting
Malaria
0 Actively Recruiting
Atrial Fibrillation
0 Actively Recruiting
Atrial Fibrillation or Flutter
1 Actively Recruiting
Not Applicable
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable
Quinidine Gluconate Reviews: What are patients saying about Quinidine Gluconate?
5Patient Review
2/27/2013 Unfortunately, this medication caused me a lot of gastrointestinal distress.
5Patient Review
11/16/20085Patient Review
8/16/2018 I've been taking this medication for 20 years and it's still working great!
4.3Patient Review
5/16/2011 This medication is especially effective at decreasing platlets in cancer patients.
4Patient Review
4/17/2013 I've been on quinidine gl for over a decade now. It's been effective for the most part, but my recent AF has required an increase in dosage. I'm now taking 486 gm three times daily and it's working, though my metabolism has taken a hit.
4Patient Review
8/25/2010 My family member was prescribed this in the 1970's for MVP, and I believe it contributed to their death at age 29.
4Patient Review
8/17/2009 I've been using this treatment for 45 years and it's really helped me manage my AFIB.
3Patient Review
6/19/2012 This medication did help me, but I've still had episodes. The doctor tried several other medications and cardio conversion a few times, but quinidine with two other drugs seems to be the most effective so far.
2.3Patient Review
3/27/2011 This drug is becoming increasingly difficult to find, but it's the only one that doesn't give me terrible allergies. I'm apparently one of only two patients at the Cleveland Clinic Foundation who still uses this medication.
Patient Q&A Section about quinidine gluconate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is quinidine gluconate an antiarrhythmic?
"Although quinidine gluconate may help to ease ventricular arrhythmias, it has not been proven to increase survival rates in patients."
Answered by AI
What is the brand name for quinidine?
"The medication Quinidine has a generic name and is available as quinidine sulfate tablets and quinidine gluconate extended-release tablets. It used to come in various brand-names such as Cardioquin, Cin-Quin, and Quinidex, but those are no longer available."
Answered by AI
What is the side effects of quinidine gluconate?
"diarrhea, nausea, vomiting, loss of appetite, stomach pain or cramps, or a burning feeling in the throat or chest (heartburn)"
Answered by AI
What is quinidine gluconate used for?
"This medication is used to treat or prevent many types of irregular heartbeats (heart arrhythmias). Quinidine can improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have."
Answered by AI