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What is Propoxyphene Hydrochloride
DextropropoxypheneThe Generic name of this drug
Treatment SummaryDextropropoxyphene is an opioid painkiller that was manufactured by Eli Lilly and Company. It was used to treat mild pain, as well as coughs. Due to the risk of overdose and deadly cardiac arrhythmias, it was removed from the market in many countries. Dextropropoxyphene is made up of two isomers, dextro- and levo-; only the dextro-isomer has any analgesic effect, while the levo-isomer only exhibits a mild cough-suppressing effect.
Propoxypheneis the brand name
Propoxyphene Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propoxyphene
Dextropropoxyphene
1973
64
Approved as Treatment by the FDA
Dextropropoxyphene, also known as Propoxyphene, is approved by the FDA for 1 uses like Chronic Pain .Chronic Pain
Helps manage Pain
Effectiveness
How Propoxyphene Hydrochloride Affects PatientsPropoxyphene is a synthetic drug similar to methadone that works as an opiate pain reliever. It helps to block pain signals so that the person taking it does not feel pain. Propoxyphene does not help with coughing or reducing fever.
How Propoxyphene Hydrochloride works in the bodyPropoxyphene works by directly interacting with your body's opioid receptors. It primarily binds to OP3 receptors, which are responsible for modulating the activity of certain proteins. When these proteins are activated, they reduce the amount of substances like dopamine and acetylcholine that your body releases. They also reduce the activity of nociceptive neurons, which helps to reduce pain. Propoxyphene also works to hyperpolarize neurons, making them less likely to fire and reducing nerve excitability.
When to interrupt dosage
The recommended dose of Propoxyphene Hydrochloride is contingent on the diagnosed condition. The measure of dosage is contingent upon the method of administration specified in the table underneath.Condition
Dosage
Administration
Chronic Pain
, 65.0 mg, 100.0 mg, 50.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral
Warnings
Propoxyphene Hydrochloride ContraindicationsCondition
Risk Level
Notes
Hypercarbia
Do Not Combine
Asthma
Do Not Combine
Mental Depression
Do Not Combine
Paralytic Ileus
Do Not Combine
Asthma Acute
Do Not Combine
Common Propoxyphene Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dextropropoxyphene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dextropropoxyphene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Dextropropoxyphene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Dextropropoxyphene.
Propoxyphene Hydrochloride Toxicity & Overdose RiskOverdosing on propoxyphene can lead to coma, difficulty breathing, decreased blood circulation, and fluid in the lungs. Patients may also experience seizures more often than those who overdose on other opioids. The lowest toxic dose in rats is 230mg/kg when taken orally.
Propoxyphene Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Propoxyphene Hydrochloride?
172 active trials are being conducted to investigate the possibility of Propoxyphene Hydrochloride providing relief for Chronic Pain sufferers.Condition
Clinical Trials
Trial Phases
Chronic Pain
175 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Propoxyphene Hydrochloride Reviews: What are patients saying about Propoxyphene Hydrochloride?
5Patient Review
12/27/2010 This medication is effective most of the time, but I have to take more of it in winter. If I do anything that's even a little bit more strenuous than walking, I have to take the full prescribed amount.
5Patient Review
1/25/2011 I've been using this medication for 20 years after my skull was crushed and it's really helped me live a normal life despite my injuries. I'm now 68 and the government is trying to take it off the market, which would be devastating for me. It's hard enough to find a place that will fill my prescription as it is.
5Patient Review
2/13/2011 Propoxphene was the only pill that worked for me. Unfortunately, some people died from mixing it with alcohol, so now the FDA has banned it. I'm in a lot of pain from two back surgeries and arthritis, and this was the only thing that helped.
5Patient Review
12/26/2011 This treatment is effective and doesn't come with any harmful side effects.
4.7Patient Review
11/29/2010 I've been using this medication for my arthritis and joint pain for years now, and it's always worked well for me. The drowsiness is a bit of a downside, but that seems to be common with narcotic pain medications.
4.7Patient Review
11/21/2010 Not as strong as I would have liked, but it does take the edge off of my pain.
4.7Patient Review
7/11/20104.3Patient Review
4/11/2014 I only use this medication when I need it, and it has been really helpful. It allows me to sleep through the night and I don't feel any pain the next day.
4Patient Review
8/7/2010 This treatment has been great for managing the pain from both my cancer and the surgery to remove it.
4Patient Review
2/17/2011 I've been taking this medicine for chronic back pain for over two decades. It's the only thing that gives me relief, which is saying a lot since I can't take most other pain medications.
3.7Patient Review
9/29/2010 After having two different shoulder surgeries, I've been on Vicodin since March. Recently, I asked my surgeon if we could try a different medication and I find that it does a much better job at keeping the pain manageable, especially when trying to sleep.
3.7Patient Review
11/20/2010 This didn't do a ton to help my pain, but it did take the edge off slightly.
3.3Patient Review
11/20/2010 I felt really drowsy after taking this medication, like I had taken too many drugs. One pill was enough to make it hard for me to walk or talk properly.
2.3Patient Review
11/21/2010 I find this just strong enough for my needs. I don't want to get addicted to another painkiller medication.
Patient Q&A Section about propoxyphene hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was propoxyphene removed from the market?
"The FDA has asked pharmaceutical companies to stop making propoxyphene (PPX) because a clinical trial showed that the drug altered the heart's electrical activity, potentially causing arrhythmias that could be serious or life-threatening."
Answered by AI
Is Tylenol a propoxyphene?
"What is acetaminophen and propoxyphene?
Acetaminophen and propoxyphene are a combination of drugs that are used to relieve pain and reduce fever. These drugs were withdrawn from the U.S. market in November 2010."
Answered by AI
Is propoxyphene a Darvocet?
"Propoxyphene is an opioid pain reliever used to treat mild to moderate pain. It is sold under various names as a single-ingredient product (e.g., Darvon) and as part of a combination product with acetaminophen (e.g., Darvocet). The use of propoxyphene has declined since 2010 due to concerns about its effectiveness and potential for abuse and overdose."
Answered by AI
Why did they pull Darvocet off the market?
"The FDA has announced that the painkiller propoxyphene is being taken off the market as it has been linked to a potentially fatal heart-rhythm abnormality, even at recommended doses."
Answered by AI