Procainamide Hydrochloride

Atrial Fibrillation, life-threatening ventricular arrhythmias, Supraventricular Arrhythmias + 1 more

Treatment

18 Active Studies for Procainamide Hydrochloride

Treatment for

Atrial Fibrillation

What is Procainamide Hydrochloride

ProcainamideThe Generic name of this drug

Treatment SummaryProcaine is a medication related to anesthetics. This derivative of procaine has a weaker effect on the central nervous system.

Procainamide Hydrochlorideis the brand name

Procainamide Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procainamide Hydrochloride

Procainamide

1976

Effectiveness

How Procainamide Hydrochloride Affects PatientsProcainamide is used to produce numbing, local or regional anesthesia, and to treat irregular heartbeats, such as those caused by surgery, cardiac manipulation, heart attack, digitalis toxicity, or other heart conditions. It works by reducing the excitability of the ventricles and increasing the amount of stimulation they need in order to contract. The sinoatrial node is not affected by procainamide.

How Procainamide Hydrochloride works in the bodyProcainamide is a drug that numbs the nerves. It does this by blocking the pathways that allow electrical signals to travel between cells, which stops the nerve from firing and thus numbing the area.

When to interrupt dosage

The proposed dosage of Procainamide Hydrochloride varies depending on the recognized condition, such as Supraventricular Arrhythmias, Ventricular Tachycardia and life-threatening ventricular arrhythmias. The measure is contingent upon the technique of implementation (e.g. Capsule, gelatin coated or Injection, solution - Intramuscular; Intravenous) featured in the following table.

Condition

Dosage

Administration

Atrial Fibrillation

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Intramuscular; Intravenous, Oral, Capsule, Capsule - Oral, Liquid, Liquid - Intramuscular; Intravenous, Tablet, extended release, Tablet, extended release - Oral, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral

life-threatening ventricular arrhythmias

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

Supraventricular Arrhythmias

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

Ventricular Tachycardia

, 500.0 mg/mL, 100.0 mg/mL, 500.0 mg, 375000.0 mg, 250.0 mg, 375.0 mg, 750.0 mg, 1000.0 mg

Warnings

Procainamide Hydrochloride has three contraindications. It should not be taken while having any of the conditions outlined in the table below.Procainamide Hydrochloride Contraindications

Condition

Risk Level

Notes

Lupus

Do Not Combine

Complete Heart Block

Do Not Combine

Torsades de Pointes

Do Not Combine

There are 20 known major drug interactions with Procainamide Hydrochloride.

Common Procainamide Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Procainamide is combined with Asenapine.

Clofarabine

Major

The serum concentration of Clofarabine can be increased when it is combined with Procainamide.

Dalfampridine

Major

The serum concentration of Dalfampridine can be increased when it is combined with Procainamide.

Procainamide Hydrochloride Toxicity & Overdose RiskThe toxic dose of a drug in rats when injected intravenously is 95 mg/kg, 312 mg/kg when given orally to mice, 103 mg/kg when injected intravenously to mice, and 250 mg/kg when injected intravenously to rabbits.

Procainamide Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Procainamide Hydrochloride?

Seventeen active trials are assessing the potential of Procainamide Hydrochloride to ameliorate life-threatening Ventricular Tachycardia, ventricular arrhythmias and pre-excited Atrial Fibrillation.

Condition

Clinical Trials

Trial Phases

Ventricular Tachycardia

18 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1

life-threatening ventricular arrhythmias

0 Actively Recruiting

Atrial Fibrillation

0 Actively Recruiting

Supraventricular Arrhythmias

0 Actively Recruiting

Patient Q&A Section about procainamide hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drugs is procainamide?

"Procainamide is a medication used to treat heart rhythm problems, including ventricular arrhythmias, supraventricular arrhythmias, atrial flutter/fibrillation, and Wolf-Parkinson-White syndrome. It is in the antiarrhythmic Agent Class 1A class of medications."

Answered by AI

What is procainamide hydrochloride used for?

"Procainamide is used to treat abnormal heart rhythms. It helps to make your heart more resistant to abnormal activity."

Answered by AI

What is the most common adverse effects of procainamide?

"The most common side effects of Pronestyl are nausea, vomiting, loss of appetite, diarrhea, bitterness in the mouth, dizziness, tiredness, and itching or rash."

Answered by AI

What is another name for procainamide?

"PRONESTYL is a medication indicated for the treatment of ventricular arrhythmias, such as sustained ventricular tachycardia, that are considered life-threatening by a physician."

Answered by AI

Clinical Trials for Procainamide Hydrochloride

Have you considered Procainamide Hydrochloride clinical trials? We made a collection of clinical trials featuring Procainamide Hydrochloride, we think they might fit your search criteria.

Explore trials for Procainamide Hydrochloride

Have you considered Procainamide Hydrochloride clinical trials? We made a collection of clinical trials featuring Procainamide Hydrochloride, we think they might fit your search criteria.