Precedex

Schizophrenia, Agitation, Sedation + 3 more
Treatment
20 Active Studies for Precedex

What is Precedex

DexmedetomidineThe Generic name of this drug
Treatment SummaryMedetomidine is a drug used in veterinary medicine to relieve pain and induce sedation. It works by stimulating certain receptors in the body and is the racemate of Dexmedetomidine.
Precedexis the brand name
image of different drug pills on a surface
Precedex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Precedex
Dexmedetomidine
2004
83

Effectiveness

How Precedex Affects PatientsDexmedetomidine works by activating certain receptors in the body, reducing the activity of the sympathetic nervous system. This leads to a decrease in anesthetic and opioid needs, as well as sedation and pain relief.
How Precedex works in the bodyDexmedetomidine works by attaching to nerve receptors in the body called alpha-2 adrenoceptors. This blocks pain signals from being sent, and also lowers blood pressure and heart rate.

When to interrupt dosage

The proposed dosage of Precedex is contingent upon the declared ailment, including Cyclic Vomiting Syndrome, Mechanical Ventilation and Disease. The quantity of dosage is contingent on the technique of delivery (e.g. Injection, solution - Intravenous or Film) specified in the table below.
Condition
Dosage
Administration
Schizophrenia
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual
Behcet Syndrome
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual
Syndrome
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual
Agitation
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual
Sedation
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual
induction of Sedation
, 0.1 mg/mL, 0.004 mg/mL, 0.1 mg, 0.02 mg/mL, 0.2 mg/mL, 0.18 mg, 0.12 mg
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Film, Sublingual, Film - Sublingual

Warnings

There are 20 known major drug interactions with Precedex.
Common Precedex Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dexmedetomidine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Dexmedetomidine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Dexmedetomidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Dexmedetomidine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Dexmedetomidine.
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Precedex Novel Uses: Which Conditions Have a Clinical Trial Featuring Precedex?

12 active clinical trials are currently analyzing the utility of Precedex for Sedative therapy, Anesthetic procedures and Cyclic Vomiting Syndrome.
Condition
Clinical Trials
Trial Phases
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Sedation
2 Actively Recruiting
Early Phase 1, Not Applicable
Agitation
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Syndrome
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
induction of Sedation
0 Actively Recruiting
Behcet Syndrome
1 Actively Recruiting
Not Applicable

Precedex Reviews: What are patients saying about Precedex?

5Patient Review
9/16/2012
Precedex for Calming of Intubated Patient by Administration of Sedative
I didn't experience any benefits from this treatment, and actually found it made me more sleepless, irritable, and nervous. Not to mention the high cost.
4.3Patient Review
1/26/2013
Precedex for Calming of Intubated Patient by Administration of Sedative
I was pretty out of it after the anesthesia wore off.
2.3Patient Review
7/1/2020
Precedex for Calming of Intubated Patient by Administration of Sedative
I was woken up abruptly by intense pain and felt nauseous afterwards.
1.7Patient Review
2/28/2010
Precedex for Calming of Intubated Patient by Administration of Sedative
I experienced severe anxiety, confusion, aggressiveness, pinpoint pupils, severe light sensitivity, nausea and tremors after taking this medication.
1.7Patient Review
11/19/2009
Precedex for Calming of Intubated Patient by Administration of Sedative
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Patient Q&A Section about precedex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Precedex preferred over propofol?

"11.2 +/- 3.4 hours, respectively).

Patients sedated with dexmedetomidine spent less time on mechanical ventilation, on average, than those sedated with propofol."

Answered by AI

What class of drug is Precedex?

"Precedex is a type of drug called a sedative. It is not known if it is safe and effective to use in children."

Answered by AI

What is Precedex used to treat?

"Precedex is a medication that is indicated for use in sedating patients who are on a ventilator and receiving treatment in an intensive care setting. This medication is to be used starting on May 1, 2022."

Answered by AI

Why is Precedex used in ICU?

"Dexmedetomidine can help sedate patients while still allowing them to be responsive, and may shorten the amount of time they need mechanical ventilation and experience delirium while in the ICU."

Answered by AI

Clinical Trials for Precedex

Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of Vanderbilt Psychiatric Hospital in Nashville, United States.

Repetitive Transcranial Magnetic Stimulation for Schizophrenia

18 - 65
All Sexes
Nashville, TN
The central hypothesis is this: DMN connectivity can be modulated with inhibitory cTBS when delivered on an accelerated treatment schedule. This study seeks to provide evidence that accelerated, network-targeted inhibitory stimulation of the DMN leads to both altered network activity and a concomitant behavioral change in cognitive performance in individuals with schizophrenia and schizoaffective disorder. This study will also compare the effect of inhibitory cTBS in healthy individuals, as it may also lead to both altered network activity and a behavioral change in cognitive performance in individuals without schizophrenia or schizoaffective disorder. If successful, this study will have identified a safe, effective, and broadly applicable treatment for cognitive impairment in schizophrenia that has potential for translation into many other psychiatric and neurodevelopmental disorders, such as autism.
Waitlist Available
Has No Placebo
Vanderbilt Psychiatric HospitalHeather Ward, MD
Have you considered Precedex clinical trials? We made a collection of clinical trials featuring Precedex, we think they might fit your search criteria.Go to Trials
Have you considered Precedex clinical trials? We made a collection of clinical trials featuring Precedex, we think they might fit your search criteria.Go to Trials
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Ketamine vs Fentanyl for Sedation in Interventional Radiology

18 - 90
All Sexes
Charleston, WV
This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.
Phase < 1
Recruiting
CAMC MemorialAmy R Deipolyi, M.D., Ph.D.
Image of Case Western Reserve University in Cleveland, United States.

Psychosocial Rehabilitation for Schizophrenia

18 - 50
All Sexes
Cleveland, OH
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions. The investigators are especially interested in learning whether the Clubhouse Model-a structured, supportive community for individuals with mental illness-has unique benefits compared to standard outpatient mental health services. If participants decide to join, they will be asked to complete a total of six study visits with the research team over the course of your participation. Three of these study visits are at the beginning (baseline) and the remaining three are six months later. Two of the three visits will includes interviews, questionnaires, and thinking and memory tasks (cognitive testing) and one session will be an MRI brain scan, which is a safe and non-invasive imaging procedure. The total time required for each visit will be approximately 90 minutes to two hours. Participants may take breaks as needed.
Waitlist Available
Has No Placebo
Case Western Reserve UniversityJessica A Wojtalik, PhD
Have you considered Precedex clinical trials? We made a collection of clinical trials featuring Precedex, we think they might fit your search criteria.Go to Trials
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