What is Prasugrel
PrasugrelThe Generic name of this drug
Treatment SummaryPrasugrel is a medication used to prevent the activation and aggregation of platelets (blood cells responsible for clotting). It works by blocking the ADP receptors on platelets, thus preventing the formation of clots. Prasugrel is a thienopyridine derivative, similar to clopidogrel and ticlopidine, and is a prodrug requiring enzymatic transformation in the liver to its active metabolite, R-138727. Prasugrel was developed by Daiichi Sankyo Co. and is approved by the FDA for use in patients with acute coronary syndromes planned
Effientis the brand name
Prasugrel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Effient
Prasugrel
2009
37
Approved as Treatment by the FDA
Prasugrel, otherwise called Effient, is approved by the FDA for 5 uses including Angina, Unstable and Percutaneous Coronary Intervention .Angina, Unstable
Percutaneous Coronary Intervention
Percutaneous Coronary Intervention
prophylaxis of cardiovascular event
Cardiovascular Events
Effectiveness
How Prasugrel Affects PatientsPrasugrel is a drug that prevents blood clots by blocking a specific receptor (P2Y12) on the surface of platelets. It binds to the receptor in an irreversible way, meaning that the effects of the drug last a long time.
How Prasugrel works in the bodyPrasugrel is a drug that stops platelets in the blood from sticking together. It does this by blocking a receptor on platelets, preventing the platelets from becoming activated. Prasugrel works in a similar way to clopidogrel.
When to interrupt dosage
The suggested measure of Prasugrel is contingent upon the diagnosed disorder, like Percutaneous Coronary Intervention, Angina, Unstable and prophylaxis of cardiovascular event. The amount of dosage relies upon the technique of delivery (e.g. Tablet, film coated - Oral or Tablet, coated - Oral) featured in the table beneath.Condition
Dosage
Administration
Percutaneous Coronary Intervention
, 5.0 mg, 10.0 mg
Tablet, film coated - Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, Tablet - Oral, Tablet, film coated, Oral
Angina, Unstable
, 5.0 mg, 10.0 mg
Tablet, film coated - Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, Tablet - Oral, Tablet, film coated, Oral
prophylaxis of cardiovascular event
, 5.0 mg, 10.0 mg
Tablet, film coated - Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, Tablet - Oral, Tablet, film coated, Oral
Percutaneous Coronary Intervention
, 5.0 mg, 10.0 mg
Tablet, film coated - Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, Tablet - Oral, Tablet, film coated, Oral
Cardiovascular Events
, 5.0 mg, 10.0 mg
Tablet, film coated - Oral, Tablet, coated - Oral, , Tablet, coated, Tablet, Tablet - Oral, Tablet, film coated, Oral
Warnings
Prasugrel ContraindicationsCondition
Risk Level
Notes
prior TIA
Do Not Combine
Stroke
Do Not Combine
Hemorrhage
Do Not Combine
Common Prasugrel Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Prasugrel is combined with Abrocitinib.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Prasugrel.
Andexanet alfa
Major
The therapeutic efficacy of Andexanet alfa can be decreased when used in combination with Prasugrel.
Anti-inhibitor coagulant complex
Major
The therapeutic efficacy of Anti-inhibitor coagulant complex can be decreased when used in combination with Prasugrel.
Antihemophilic factor (recombinant), PEGylated
Major
The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Prasugrel.
Prasugrel Toxicity & Overdose RiskThe toxic dose of this drug in rats is between 1,000 and 2,000 milligrams per kilogram of body weight, while in rabbits it is greater than 1,000 milligrams per kilogram.
Prasugrel Novel Uses: Which Conditions Have a Clinical Trial Featuring Prasugrel?
Currently, three trials are underway to ascertain the efficacy of Prasugrel in Percutaneous Coronary Intervention, Unstable Angina and other associated conditions.Condition
Clinical Trials
Trial Phases
Percutaneous Coronary Intervention
0 Actively Recruiting
Percutaneous Coronary Intervention
0 Actively Recruiting
Angina, Unstable
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Cardiovascular Events
5 Actively Recruiting
Not Applicable
Prasugrel Reviews: What are patients saying about Prasugrel?
5Patient Review
11/3/2013 I've been taking this for three years with no issues--until now. I recently had to have a heart cath and my platelet count was too low. They did two IVs of platelets and it raised my count enough to be safe. I'm wondering what would happen in an emergency situation though.
5Patient Review
4/25/2018 I've been on this medication for 11 months now. It does take a little longer for blood to clot, but I haven't had any problems with black tarry stool.
5Patient Review
2/15/2013 I was really struggling to sleep before I tried this treatment, but it's been absolutely wonderful. No more restless legs!
4.7Patient Review
8/29/2015 I'm early in taking this drug, but it's going well so far. I take aspirin 81 mg with it and have had no bruising or bleeding.
4Patient Review
12/26/20102.7Patient Review
1/26/2012 I bruise and bleed very easily, which is both unsightly and inconvenient. I take an aspirin with this medication, which helps a little bit.
Patient Q&A Section about prasugrel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is prasugrel used for?
"Prasugrel is used to prevent strokes, heart attacks, or other serious problems with your heart or blood vessels. It is given to patients before they have a heart procedure called percutaneous coronary intervention (PCI)."
Answered by AI
What is the difference between Plavix and prasugrel?
"Prasugrel is a thienopyridine that works faster than clopidogrel. Dr. Kereiakes said Effient is absorbed by the body more quickly through the intestines and only requires one chemical conversion process in the liver. Plavix requires two chemical reactions to convert it from a prodrug to an active drug."
Answered by AI
What are the side effects for prasugrel?
"The following are side effects that may occur: bleeding, anemia, atrial fibrillation, back pain, slow heart rate, dizziness, shortness of breath, headache."
Answered by AI
Is prasugrel a blood thinner?
"Effient is a blood thinner that prevents heart attacks by making it less likely for blood clots to form after a stent is placed in the heart."
Answered by AI